Purpose: To report two clinical cases of patients having severe keratoconjunctivitis sicca refractive to conventional treatment that received rituximab, a chimeric monoclonal antibody specific for human CD20 that targets B lymphocytes.
Methods: Clinical description and review of the literature.
Results: After treatment with rituximab, there was a marked improvement in their keratoconjunctivitis sicca and in other systemic manifestations of the disease.