Obesity, dyslipidemia, and high blood pressure are associated with cardiovascular risk, determined using high-sensitivity C-reactive protein concentration, in young adults.

Objective: Few studies have investigated the relationships between high-sensitivity C-reactive protein (hs-CRP) concentration and conventional cardiometabolic markers in young adults. The aim of this study was to characterize the cardiometabolic profile of young adults who are at high cardiovascular risk, according to hs-CRP concentration.

Methods: A cross-sectional study was conducted in 300 young adults (18 to 30 years old) from southern Mexico (n = 150 normal-weight and n = 150 obese).

A possible association between the -2518 A>G MCP-1 polymorphism and insulin resistance in school children.

Objective Monocyte chemoattractant protein 1 (MCP-1) has been suggested to be involved in the pathophysiology of insulin resistance (IR); therefore, variants in the MCP-1 gene may contribute to the development of this disease. The aim of this study was to analyze the relationship of the -2518 A>G MCP-1 (rs1024611) gene polymorphism with insulin resistance in Mexican children. Subjects and methods A cross-sectional study was performed in 174 children, including 117 children without insulin resistance and 57 children with IR, with an age range of 6-11 years.

PAI-1 haplogenotype confers genetic susceptibility for obesity and hypertriglyceridemia in Mexican children.

The presence of childhood obesity predisposes to the development of cardiovascular and metabolic diseases, such as coronary artery disease and type 2 diabetes mellitus, in adulthood. The polymorphisms described in PAI-1 gene have been linked with obesity and metabolic syndrome in several populations. The aim of this study was to investigate the association of the -844 G/A (rs2227631), -675 4G/5G (rs1799889) and HindIII C/G (rs757716)PAI-1 polymorphisms with obesity and dyslipidemia in a sample of Mexican children.

Body fat distribution and its association with hypertension in a sample of Mexican children.

Background: The association between elevated blood pressure and childhood overweight and obesity has been documented in several studies. However, the linkage of blood pressure with body fat distribution in children is not well established. We investigated the relationship between both central and subcutaneous adiposity with BP in the 95th percentile or higher in Mexican children.