Renin-angiotensin-system increases phosphorylated tau and Reactive Oxygen Species in human cortical neuron cell line.

Alzheimer's Disease (AD) is the most common cause of dementia. AD patients had increased extracellular amyloid β plaques and intracellular hyperphosphorylated tau (p-tau) in neurons. Recent studies have shown an association between the Renin-Angiotensin System (RAS) and AD.