Silver nanoparticles induce a non-immunogenic tumor cell death.

Immunogenic cell death (ICD) is a form of cell death characterized by the release of danger signals required to trigger an adaptive immune response against tumor-associated antigens. Silver nanoparticles (AgNP) display anti-proliferative and cytotoxic effects in tumor cells, but it has not been previously studied whether AgNP act as an ICD inductor. The present study evaluated the release of calreticulin as a damage-associated molecular pattern (DAMP) associated with the cytotoxicity of AgNP and their anti-cancer effects.

Bioinformatic Analysis of the Effect of Silver Nanoparticles on Colorectal Cancer Cell Line.

Colorectal cancer (CRC) is the most diagnosed cancer with the highest mortality rate each year globally. Although there are treatments for CRC, the development of resistance to therapies decreases the success of treatments. studies using the Caco-2 cell line have revealed the anticancer properties of silver nanoparticles (AgNPs) as a possible treatment for this disease.

Relation of serum IL-32 levels and gene polymorphism rs45499297 with obesity in Mexican patients: a laboratory and in silico analysis.

Background: many genes have been involved in the development of obesity. Interleukin 32 (IL-32) is a proinflammatory cytokine; rs45499297 is a T/C promoter, single-nucleotide polymorphism of the IL32 gene. Objectives: this study aimed to evaluate the rs45499297 polymorphism and its association with obesity.

Tumour necrosis factor-alpha polymorphism -308 G/a and its protein in subjects with gingivitis.

Objective: This study examined the association between tumour necrosis factor-alpha ( α (-308 G/A) polymorphism and gingivitis, and serum and salivary TNF- α levels, in a Mexican population.

Material And Methods: This study enrolled 171 subjects, divided into two groups: healthy subjects and gingivitis patients. α (-308 G/A) gene polymorphism was analyzed by PCR-RFLP assay.

Innate and adaptive immunity of periodontal disease. From etiology to alveolar bone loss.

Periodontal disease refers to inflammation of the tissues that support the tooth. It is of multifactorial etiology. Innate and adaptive immune cells participate jointly through the release of their molecules and mechanisms of action in order to maintain homeostasis in periodontal tissues, so the host's immune response plays an essential role in defense against microorganisms.