Intranasal insulin for the treatment of olfactory dysfunction: a protocol for a systematic review and meta-analysis.

Introduction: Olfactory dysfunction (OD) is a prevalent nasal affliction that has detrimental effects on the patients' quality of life and safety. Conventional therapeutic strategies have various limitations such as high costs, prolonged treatment durations and adverse side effects. Intranasal insulin is a novel intervention for the management of OD.

Radiotherapy-Related Quality of Life in Nasopharyngeal Carcinoma Patients: A Systematic Review and Meta-Analysis.

Introduction: This systematic review and meta-analysis evaluated the quality of life (QoL) for nasopharyngeal carcinoma (NPC) patients with radiotherapy.

Methods: A systematic literature search was performed to identify relevant studies published until March 2022. Quality evaluation and data extraction were performed for the included studies, and meta-analysis was performed using Stata.

Correlation among post-surgery recurrence of CRSwNP and TCM syndromes and tissue inflammatory cell infiltration type: a study protocol.

Background: Functional endoscopic sinus surgery is a principal option for treating chronic rhinosinusitis with nasal polyps (CRSwNP) after medication failures. Unfortunately, some patients still have unsatisfactory postoperative recovery. The type of inflammatory cell infiltration in nasal polyp tissue has been reported available for recurrence prediction.

The potential application and molecular mechanisms of natural products in the treatment of allergic rhinitis: A review.

Backgrounds: Allergic rhinitis (AR) is a non-infectious chronic inflammation of the nasal mucosa mainly mediated by immunoglobulin E (IgE) in atopic individuals after exposure to allergens. The application of AR guideline-recommended pharmacotherapies can rapidly relieve symptoms of AR but with poor long-term efficacy, and many of these therapies have side effects. Many natural products and their derivatives have shown potential therapeutic effects on AR with fewer side effects.

TikTok Videos Related to Rhinoplasty in China: Characteristics and the Quality of the Information.

Background: There are numerous videos related to rhinoplasty on TikTok in China. The objective is to examine videos on Chinese TikTok regarding rhinoplasty surgery and evaluate the content quality of rhinoplasty-related videos on TikTok.

Method: We collected 184 Chinese video samples related to rhinoplasty and extracted basic information.

Efficacy and safety of CM310 in severe eosinophilic chronic rhinosinusitis with nasal polyps (CROWNS-1): a multicentre, randomised, double-blind, placebo-controlled phase 2 clinical trial.

Background: Severe eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP) remains the most relapsed subtype of uncontrolled CRSwNP. CM310, a humanised anti-interleukin (IL)-4 receptor alpha monoclonal antibody, inhibits IL-4 and IL-13 signaling which underlying eosinophilic inflammation. This study aims to evaluate the efficacy and safety of CM310 in patients with severe ECRSwNP.

Transmissive Mode Laser Micro-Ablation Performance of Ammonium Dinitramide-Based Liquid Propellant for Laser Micro-Thruster.

The transmissive mode laser micro-ablation performance of near-infrared (NIR) dye-optimized ammonium dinitramide (ADN)-based liquid propellant was investigated in laser plasma propulsion using a pulse YAG laser with 5 ns pulse width and 1064 nm wavelength. Miniature fiber optic near-infrared spectrometer, differential scanning calorimeter (DSC) and high-speed camera were used to study laser energy deposition, thermal analysis of ADN-based liquid propellants and the flow field evolution process, respectively. Experimental results indicate that two important factors, laser energy deposition efficiency and heat release from energetic liquid propellants, obviously affect the ablation performance.

Individual exposure of ambient particulate matters and eosinophilic chronic rhinosinusitis with nasal Polyps: Dose-Response, mediation effects and recurrence prediction.

Purpose: We evaluated the association between ambient particulate matter (PM) exposure and eosinophilic chronic rhinosinusitis with nasal polyps (CRSwNP), and predicted the CRSwNP recurrence risk using machine learning algorithms.

Methods: In total, 1,086 patients with CRSwNP were recruited from nine hospitals in China during 2014-2019. The average annual concentrations of ambient PMs before surgery were assessed using satellite-based daily concentrations of PM and PM for a 1 × 1-km area.

Case report: Endoscopic frontal sinus opening surgery for noninflammatory frontal sinus headache: A short case series.

Objective: The objectives of this study were to analyze rhinogenic headache, i.e., noninflammatory frontal sinus headache, a headache caused by bony obstruction of the frontal sinus drainage channels that receives relatively insufficient attention clinically, and to propose endoscopic frontal sinus opening surgery as a treatment based on the etiology.

Metal micro/nanostructure enhanced laser-induced breakdown spectroscopy.

This study used a femtosecond laser to ablate a Cu sample, forming a micro/nanostructural layer on the surface. And the effect of this structural layer on nanosecond laser-induced breakdown spectroscopy (LIBS) was discussed. Firstly, the effect of the micro/nanostructural layer on the intensity of laser-induced Cu plasma spectra was investigated.

Auricular acupressure for adverse events following immunization after COVID-19 vaccine injection: A multicentre, blinded, randomized controlled trial.

Background: Some adverse events following immunization (AEFI) were observed in potential corelation with COVID-19 vaccination but without prevention or ongoing trial for it. We aimed to investigate efficacy of auricular acupressure (AuriAc) therapy in preventing AEFI after first dosage of the vaccine.

Methods: We performed a multicentre randomized controlled trial with three arms, including AuriAc, SAuriAc (sham auricular acupressure), and TrAsU (treatment as usual) group, carried out in four medical institutions in Chengdu, China, from March 17th to April 23rd, 2021.

Auricular acupressure for adverse events following immunization related to COVID-19 vaccine injection: study protocol for a multicenter, three-arm, blinded randomized controlled trial.

Background: Some pain, fatigue, and gastrointestinal adverse events were observed in potential association with injection of COVID-19 vaccines, while there was no preventive intervention for it. We aim to investigate the efficacy of auricular acupressure (AA) therapy in preventing and relieving AEFI after injection of COVID-19 vaccine.

Methods: The study design is a randomized, multicentre, three-arm controlled, single-blind trial.

Traditional Chinese medicine auricular point acupressure for the relief of pain, fatigue, and gastrointestinal adverse reactions after the injection of novel coronavirus-19 vaccines: a structured summary of a study protocol for a multicentre, three-arm, single-blind, prospective randomized controlled trial.

Objectives: To investigate if traditional Chinese medicine (TCM) auricular point acupressure (APA) can alleviate and (or) reduce the pain (including injection site pain, headache, other muscle and joint pain), fatigue, and gastrointestinal adverse reactions (including nausea, vomiting, diarrhea), after the injection of novel coronavirus-19 vaccines (NCVs).

Trial Design: The study is designed as a multicentre, parallel-group, three-arm, single-blind, prospective, randomized (1:1:1 ratio) study.

Participants: More than 360 participants will be recruited from healthy people who vaccinate NCVs in 5 community healthcare centres in the Sichuan province of China and 1 university hospital (Hospital of Chengdu University of Traditional Chinese Medicine).

38-year-old woman with nasal congestion: A rare case of septum-originated benign fibrous histiocytoma.

Introduction: Benign fibrous histiocytoma (BFH) is a mesenchymal tumor composed of fibroblasts and histiocytes, which normally occurs in the bone tissue and/or the skin of the limbs. BFH of the nasal septum is rare worldwide.

Patient Concerns: A 38-year-old female patient attended our clinic with congestion in her right nasal cavity.

Self-propulsion of catalytic nanomotors synthesised by seeded growth of asymmetric platinum-gold nanoparticles.

Asymmetric bimetallic nanomotors are synthesised by seeded growth in solution, providing a convenient and high-throughput alternative to the usual top-down lithographic fabrication of self-propelled catalytic nanoparticles. These synthetic nanomotors catalyse HO decomposition and exhibit enhanced diffusion that depends on fuel concentration, consistent with their chemical propulsion.

Observation of nanoimpact events of catalase on diamond ultramicroelectrodes by direct electron transfer.

We report electrochemical detection of single-catalase collisions at diamond ultramicroelectrodes and show the operative mechanism involves direct enzyme-mediated charge transfer between electrode and solution. Hydrogen peroxide increases the collision frequency, which fluorescence correlation spectroscopy diffusion measurements suggest stems from an increase in the diffusion rate as the underlying cause.

Novel Modifications to Carbon-Based Electrodes to Improve the Electrochemical Detection of Dopamine.

In this work, we describe three simple modifications to carbon electrodes that were found to improve the detection of an exemplar neurotransmitter (dopamine) in the presence of physiological interferents (ascorbic acid and/or uric acid). First, the electro-oxidation of ascorbic acid, as a pretreatment, at boron-doped diamond electrode (BDE) interfaces is studied. This treatment did suppress the detection of ascorbic acid oxidation signal, but only in a manner suitable for single-use detection of high concentrations of dopamine (i.

Electroacupuncture for Tinnitus: A Systematic Review.

Background: Treatment effects of electroacupuncture for patients with subjective tinnitus has yet to be clarified.

Objectives: To assess the effect of electroacupuncutre for alleviating the symptoms of subjective tinnitus.

Methods: Extensive literature searches were carried out in three English and four Chinese databases (PubMed, EMBASE, Cochrane Library, CNKI, Wanfang Chinese Digital Periodical and Conference Database, VIP, and ChiCTR).

Cellulose-Derived Supercapacitors from the Carbonisation of Filter Paper.

Advanced carbon materials are important for the next-generation of energy storage apparatus, such as electrochemical capacitors. Here, the physical and electrochemical properties of carbonised filter paper (FP) were investigated. FP is comprised of pure cellulose and is a standardised material.

Effectiveness of strengthened stimulation during acupuncture for the treatment of allergic rhinitis: study protocol for a randomized controlled trial.

Background: The traditional Chinese theory of acupuncture emphasizes that the intensity of acupuncture must reach a threshold to generate de qi (a specific and compound sensation during the acupuncture), which is necessary to achieve the best therapeutic effect. However, the notion that de qi must be achieved for maximum benefit has not been confirmed by modern scientific evidence. This study aims to compare the efficacy of acupuncture with either strong (intended to elicit de qi) or weak stimulation among patients with allergic rhinitis.

Geometric thermal phase diagrams for studying the thermal dynamic stability of hollow gold nanoballs at different temperatures.

Thermal stability is one of the main concerns for the synthesis of hollow nanoparticles. In this work, molecular dynamics simulation gave an insight into the atomic reconstruction and energy evolution during the collapse of hollow gold nanoballs, based on which a mechanism was proposed. The stability was found to depend on temperature, its wall thickness and aspect ratio to a great extent.

Clinical effect of catgut implantation at acupoints for allergic rhinitis: study protocol for a randomized controlled trial.

Background: Catgut implantation at acupoints has been used in China to treat allergic rhinitis (AR) for a long time. However, its efficacy and safety in the treatment of AR is controversial due to the poor quality of the clinical trial of this therapy. This study aims to identify whether catgut implantation at acupoints is indeed an effective and safe treatment for patients with persistent or intermittent allergic rhinitis (PER or IAR) by comparing with sham catgut implantation treatment.

Template-free synthesis of mesoporous N-doped SrTiO3 perovskite with high visible-light-driven photocatalytic activity.

An effective, template-free synthesis methodology has been developed for preparing mesoporous nitrogen-doped SrTiO(3) (meso-STON) using glycine as both a nitrogen source and a mesopore creator. The N-doping, large surface area and developed porosity endow meso-STON with excellent activity in visible-light-responsive photodegradation of organic dyes.

Theoretical investigation on the influence of temperature and crystallographic orientation on the breaking behavior of copper nanowire.

In this paper, molecular dynamics simulations have been conducted to study the mechanical stretching of copper nanowires which will finally lead to the formation of suspended liner atomic chains. A total of 2700 samples have been investigated to achieve a comprehensive understanding of the influence of temperature and orientation on the formation of linear atomic chains. Our results prove that linear atomic chains do exist for [100], [111] and [110] crystallographic directions.