EX527, a sirtuins 1 inhibitor, sensitizes T-cell leukemia to death receptor-mediated apoptosis by downregulating cellular FLICE inhibitory protein.

Death receptor-mediated extrinsic apoptosis system had been developed as a promising therapeutic strategy in clinical oncology, such as TRAIL therapy. However, multiple studies have demonstrated that TRAIL resistance is the biggest problem for disappointing clinical trials despite preclinical success. Targeting cellular FLICE inhibitory protein (cFLIP) is one strategy of combinatorial therapies to overcome resistance to DR-mediated apoptosis due to its negative regulator of extrinsic apoptosis.

A Novel Strategy to Fabricate Cation-Cross-linked Graphene Oxide Membrane with High Aqueous Stability and High Separation Performance.

Graphene oxide (GO) membranes have shown enormous promise in desalination and molecular/ionic sieving. However, the instability of GO membranes in aqueous solutions seriously hinders their practical applications. Herein, we report a novel and simple strategy to fabricate stable GO membranes in water-based environments through the insertion of various metal cations from metal foils (.

Nanostructured Thermoresponsive Surfaces Engineered via Stable Immobilization of Smart Nanogels with Assistance of Polydopamine.

Thermoresponsive surfaces featured with nanostructures have found wide potential applications in biological and chemical fields. Herein, we report nanostructured thermoresponsive surfaces engineered via stable immobilization of thermoresponsive nanogels with the assistance of polydopamine. The results show that the thin layer of polydopamine on the poly( N-isopropylacrylamide) (PNIPAM) nanogels nearly does not affect the thermoresponsive property of the nanogels.

Novel Smart Microreactors Equipped with Responsive Catalytic Nanoparticles on Microchannels.

Nowadays efficient and reliable control of highly exothermic reactions to effectively prevent overheating or even explosions still remains a challenging task, although newly developed microreactor technology has shown promise. Here, we report a novel smart microreactor system equipped with responsive catalytic nanoparticles on microchannels for self-regulated control over highly exothermic reactions by responding to the reaction-generated heat. On the basis of shrinking/swelling behaviors of polymeric networks in the responsive catalytic nanoparticles, the smart microreactor could respond to the change of reaction temperature to tune the catalysis activity of catalytic particles in a thermo-feedback process.

[Analysis of prognostic factors in patients with huge primary liver cancer after surgical resection].

Objective: To analyze the prognostic factors in patients after surgical resection of a huge primary liver cancer (HPLC).

Methods: Clinical and follow-up data of 69 cases of huge HPLC treated in our hospital from July 2001 to July 2008 were retrospectively analyzed. Sixteen clinicopathologic factors possibly influencing the survival were selected, and multivariate analysis of these parameters was performed using the Cox proportional hazards model.

[Diagnosis and treatment for solitary necrotic nodule of the liver: report of 15 patients].

Objective: To investigate the diagnostic and therapeutic approach of solitary necrotic nodule of the liver (SNNL).

Methods: Fifteen cases were diagnosed as SNNL from June 1999 to December 2005. The clinical characteristics, imaging findings, diagnosis and treatment were analyzed with related literature retrospectively.