Efficacy and safety of camrelizumab plus famitinib in patients with previously treated non-small-cell lung cancer: a single-arm, phase II trial.

Background: For non-small-cell lung cancer (NSCLC) patients who progressed after first-line chemotherapy, immunotherapy targeting programmed cell death (ligand) 1 has shown promising activity. However, the activity is relatively limited in patients harboring epidermal growth factor receptor (EGFR) mutations.

Objectives: This study aimed to evaluate the efficacy and safety of camrelizumab plus famitinib in previously treated patients with locally advanced and metastatic NSCLC.

Breaking through the pH Limitation of FeS Nanozymes Using Component-Modulated Coupled Nanoclay.

Overcoming the intrinsic low activity of most peroxidase mimics under neutral pH is crucial but still extremely challenging for the detection of disease markers in biological samples. Here, we chose nanoclay (i.e.

Mineral Phase Reconfiguration Enables the High Enzyme-like Activity of Vermiculite for Antibacterial Application.

Phyllosilicates-based nanomaterials, particularly iron-rich vermiculite (VMT), have wide applications in biomedicine. However, the lack of effective methods to activate the functional layer covered by the external inert layer limits their future applications. Herein, we report a mineral phase reconfiguration strategy to prepare novel nanozymes by a molten salt method.

Mineral-Enhanced Manganese Ferrite with Multiple Enzyme-Mimicking Activities for Visual Detection of Disease Markers.

Local geometric configurations of metal cations in inorganic enzyme mimics determine their catalytic behaviors, while their optimization remains challenging. Herein, kaolinite, a naturally layered clay mineral, achieves the optimization of cationic geometric configuration in manganese ferrite. We demonstrate that the exfoliated kaolinite induces the formation of defective manganese ferrite and makes more iron cations fill into the octahedral sites, significantly enhancing the multiple enzyme-mimicking activities.

Nanoclay Modulates Cation Occupancy in Manganese Ferrite for Catalytic Antibacterial Treatment.

Controllable preparation is the current frontier in the field of inorganic nanomaterial-based artificial enzymes (nanozymes). For ferrites, the factors affecting cation occupancy are very complex, making the modulation of cation occupancy extremely challenging. Herein, we report a new strategy to modulate the cation occupancy of manganese ferrite (MFO) based on the structural properties of nanoclay (i.

Surface acidity modulates the peroxidase-like activity of nanoclay.

A novel surface acidity modulation strategy allows us to obtain modified nanoclay with specific peroxidase (POD)-like catalytic activity. Fe exchange could increase the surface acidity of modified montmorillonite (MMT), resulting in a significant enhancement of its POD-like activity. We proposed that the POD-like catalytic reaction followed the electron transfer pathway and ping-pong mechanism.

[SNP in differentially methylated region upstream of H19 gene in Chinese Korean nationality].

Objective: To investigate SNP and distribution of haplotypes in differentially methylated region (DMR) upstream of H19 gene in Chinese Korean nationality in order to provide basic data for forensic application and population genetics research.

Methods: One hundred and one blood samples from unrelated Chinese Korean individuals and 14 blood samples from 5 Chinese Korean intergenerational families which known genetic relationship were collected. The SNP in DMR upstream of H19 gene were investigated by PCR-cycle sequencing and McrBC digestion followed by PCR.