Tongnao Decoction (TND) Alleviated Atherosclerosis by Playing Lowering Lipid, Anti-Inflammatory, and Antioxidant Roles.

Background: Tongnao decoction (TND) has been extensively prescribed for the treatment of stroke. However, little is known about the role of TND in the progression of carotid atherosclerosis.

Methods: A mouse carotid atherosclerosis model was established with a silastic collar placed around the right common carotid artery and fed on Western diet for 12 weeks.

Boosting light harvesting and charge separation of WO coupling with CuO/CuO towards highly efficient tandem photoanodes.

Photoanodes based on semiconductor WO have been attractive due to its good electron mobility, long hole-diffusion length, and suitable valence band potential for water oxidation. However, the semiconductor displays disadvantages including a relatively wide bandgap, poor charge separation and transfer, and quick electron-hole recombination at the interface with the electrolyte. Here we present a significantly improved photoanode with a tandem structure of ITO/WO/CuO/CuO, which is prepared first by hydrothermally growing a layer of WO on the ITO surface, then by electrodepositing an additional layer of CuO, and finally by heat-treating in the air to form an exterior layer of CuO.

Enhanced electrochromic switches and tunable green fluorescence based on terbium ion doped WO films.

Multifunctional WO-based materials have been increasingly attracting attention due to their unique physical and electrochemical nature. In this work, the luminescent species, terbium (Tb) ions, were first successfully doped into WO films by a hydrothermal method to incorporate their electrochromic and photoluminescent functions. The amorphous state and porous net structure are introduced, which can be attributed to the inhibited orientation growth caused by the occupation of Tb ions in the WO lattice.

Gradient Redox-Responsive and Two-Stage Rocket-Mimetic Drug Delivery System for Improved Tumor Accumulation and Safe Chemotherapy.

Recent drug delivery nanosystems for cancer treatment still suffer from the poor tumor accumulation and low therapeutic efficacy due to the complex biological barriers. To resolve these problems, in this work, a novel gradient redox-responsive and two-stage rocket-mimetic drug nanocarrier is designed and constructed for improved tumor accumulation and safe chemotherapy. The nanocarrier is constructed on the basis of the disulfide-doped organosilica-micellar hybrid nanoparticles and the following dual-functional modification with disulfide-bonded polyethylene glycol (PEG) and amido-bonded polyethylenimine (PEI).

[PLK1 Expression in Mantle Cell Lymphoma and Its Clinical Significance].

Objective: To explore the expression level of PLK1 in mantle cell lymphoma(MCL), and the effect of silencing PLK1 gene by RNA interference on the cell proliferation, apoptosis, and cell cycle.

Methods: S-P immunohistochemistry technique was used to detect the expression of PLK1 in tissues of 42 patients with MCL and 30 patients with reactive proliferative lymphodenitis(RPL), their expression levels were compared and analyzed. The Jeko-1 cells were transfected with lentivirus contaiming PLK-1 shRNA, then the mRNA and protein expression of PLK-1 was detected by real-time guantitative PCR and Western blot nespectively, and the silencing efficacy of PLK-1 shRNA was identificd.

[Determination of five aminoglycoside residues in honey using mixed-mode ion exchange liquid chromatography-tandem mass spectrometry].

A method using mixed-mode ion exchange liquid chromatography-tandem mass spectrometry was developed for the determination of streptomycin, dihydrostreptomycin, spectinomycin, kanamycin and amikacin in honey. The honey samples were extracted with phosphate followed by clean-up with SupelMIP Aminoglycosides SPE cartridges. The separation was performed on an SIELC Obelisc R column (100 mm×2.

Facile synthesis of organosilica-capped mesoporous silica nanocarriers with selective redox-triggered drug release properties for safe tumor chemotherapy.

As drug-delivery carriers for cancer chemotherapy, gatekeeper-capped mesoporous silica nanoparticles (MSNs) have been widely studied due to their high drug-loading capability, controlled drug release property and good biocompatibility. However, the currently reported gatekeeper-capped MSNs suffer from complex synthetic procedures, potential toxicity of gatekeepers, unsatisfactory control on drug stimuli-release, etc. In this work, we develop a simple but efficient approach to fabricate PEGylated organosilica-capped mesoporous silica nanoparticles (POMSNs) by employing a disulfide-doped organosilica coating as the gatekeeper formed by the hydrolysis and condensation of a silane coupling agent 3-(mercaptopropyl)trimethoxysilane (MPTMS) to block the mesopores of MSNs.