Fluid Multivalent Recognition Accelerating and Boosting Upconversion Luminescence-Activated DNA Nanomachines for Rapid and Sensitive Imaging.

By integrating near-infrared (NIR) light-dependent optical control and DNA walkers-based signal amplification, upconversion luminescence-activated DNA nanomachines hold great potential in conducting an analysis. For the typical DNA nanomachines, the immobile multivalent recognition interface greatly compromised the reaction kinetics and amplification efficiency due to the cleavage-dependent response mode. In this work, novel upconversion luminescence-activated DNA nanomachines with a fluid multivalent recognition interface were reported for rapid and sensitive imaging.

Potential role of exogenous melatonin involved in postharvest quality maintenance of Vitis labrusca × vinifera 'Kyoho'.

Background: Melatonin is an endogenous free radical scavenger with antioxidant activity that preserves the commercial value of postharvest fruits and delays fruit senescence. To explore the effect of exogenous melatonin on antioxidants and aroma volatile compounds of grapes (Vitis labrusca × vinifera 'Kyoho'), the grapes were treated with distilled water (control), 50 μmol L of melatonin (M50), and 100 μmol L of melatonin (M100) for 30 min and were then stored at 4 °C for 25 days.

Results: Exogenous melatonin decreased the rachis browning index, the decay development, the weight loss rate, the berry abscission rate, and the respiration rate, promoted the accumulation of total phenolics and total flavonoids, and delayed the reduction of anthocyanins and total soluble solids.

The Grade of Dried Jujube ( Mill. cv. Junzao) Affects Its Quality Attributes, Antioxidant Activity, and Volatile Aroma Components.

Jujube ( Mill. cv. Junzao) has attracted a large number of consumers because it is rich in nutrients, such as carbohydrates, organic acids, and amino acids.

Partial compression increases acidity, but decreases phenolics in jujube fruit: Evidence from targeted metabolomics.

Jujube fruit (Ziziphus jujuba Mill.) is extremely susceptible to mechanical injury by extrusion and collision during storage, transportation and processing. In this study, we examined the morphology and endogenous metabolism of jujubes at three developmental stages after applying partial compression (PC) to mimic mechanical injury.

Clinical efficacy of vitamin B in the treatment of mouth ulcer: a systematic review and meta-analysis.

Background: Our study sought to determine the efficacy of vitamin B in treating mouth ulcers.

Methods: The databases PubMed, Web of Science, Embase, Chinese National Knowledge Infrastructure (CNKI), and Wanfang were comprehensively searched to identify relevant articles published between 2010 and 2021. Subsequently, the clinical efficacy of vitamin B in the treatment of mouth ulcers was comprehensively and quantitatively evaluated through meta-analysis.

Molecular interplay between microRNA-130a and PTEN in palmitic acid-mediated impaired function of endothelial progenitor cells: Effects of metformin.

Metformin serves an important role in improving the functions of endothelial progenitor cells (EPCs). MicroRNAs (miRNAs), small non‑coding RNAs, have been investigated as significant regulators of EPC vascular functions. The present study investigated the molecular crosstalk between metformin and miRNA‑130a (miR‑130a) in the functions of EPCs exposed to palmitic acid (PA).

A GLP‑1 receptor agonist attenuates human islet amyloid polypeptide‑induced autophagy and apoptosis in MIN6 cells.

Type 2 diabetes mellitus (T2DM) is characterized by the dysfunction and loss of pancreatic islet β‑cells, in part due to islet amyloid deposits derived from islet amyloid polypeptide (IAPP). The glucagon‑like peptide‑1 (GLP‑1) receptor agonist exendin‑4 enhances the insulin secretory response by increasing β‑cell mass in T2DM. However, it is unknown whether exendin‑4 protects β‑cells from IAPP‑mediated autophagy and apoptosis.

Association Between 25-Hydroxyvitamin D and Epicardial Adipose Tissue in Chinese Non-Obese Patients with Type 2 Diabetes.

BACKGROUND Epicardial adipose tissue (EAT) is recognized as a useful indicator for type 2 diabetes mellitus (T2DM) and obesity. However, studies on the association between vitamin D status and EAT thickness in type 2 diabetes (T2D) are limited. In this study, we aimed to evaluate the association of vitamin D (Calcifediol) status and EAT thickness (EATT) in Chinese non-obese patients with T2D.