Publications by authors named "Luyi Guo"

A novel monoraphid diatom species, You, Yu, Kociolek & Wang, is examined and described from the Qingyi River and Maolan Nature Reserve of southern China. The morphological description is based on light microscopy and scanning electron microscopy observations and the new species is compared with similar taxa in this genus. The characteristics unique to include its central area extending irregularly to both sides, it having closed valvocopulae with heavily silicified fimbriate margins and poles of the valvocopulae have 'sword-shaped' siliceous extensions.

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Article Synopsis
  • The article discusses the identification of strong inhibitors for Polo-like kinase 1 (PLK1), focusing on a compound known as 12c (MLN0905) derived from benzolactam.
  • Optimization efforts led to the creation of 12c, which is effective when taken orally.
  • Experiments in mice showed that 12c can significantly inhibit tumor growth or even cause tumor regression in human colon cancer models.
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Preparative chemical methods for the synthesis of eight oxidative transformation products of ethinyl estradiol (EE) and norethindrone acetate (NA) are described. The prepared materials are useful as reference materials and standards for pharmaceutical analysis of EE and NA as bulk chemical or in formulated product. All eight products result from oxidation of the A and/or B rings of the parent compounds.

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