The efficacy and safety of Bazi Bushen Capsule in treating premature aging: A randomized, double blind, multicenter, placebo-controlled clinical trial.

Purpose: It is unclear whether traditional Chinese patent medicines can resist premature aging. This prospective study investigated the effects of Bazi Bushen Capsule (BZBS) which is a traditional Chinese patent medicine for tonifying the kidney essence on premature senility symptoms and quality of life, telomerase activity and telomere length.

Study Design And Methods: It was a parallel, multicenter, double-blind, randomized, and placebo-controlled trial.

Nine dietary habits and risk of colorectal cancer: a Mendelian randomization study.

Background: Epidemiological studies have provided evidence that there is an association between diet and colorectal cancer. However, the causal relationship between dietary habits and colorectal cancer remains unknown.

Methods: The UK Biobank provided summary-level genome-wide association study data for nine dietary habits, including alcohol consumption (n = 549,703), instant coffee consumption (n = 250,308), fruit consumption (n = 210,947), meat consumption (n = 210,947), full cream milk consumption (n = 41,306), sweets consumption (n = 25,521), tea consumption (n = 501,494), vegetable consumption (n = 210,947), and yogurt/ice cream consumption (n = 210,947).

Mitophagy in atherosclerosis: from mechanism to therapy.

Mitophagy is a type of autophagy that can selectively eliminate damaged and depolarized mitochondria to maintain mitochondrial activity and cellular homeostasis. Several pathways have been found to participate in different steps of mitophagy. Mitophagy plays a significant role in the homeostasis and physiological function of vascular endothelial cells, vascular smooth muscle cells, and macrophages, and is involved in the development of atherosclerosis (AS).

Meta-analysis: Early Age at Natural Menopause and Risk for All-Cause and Cardiovascular Mortality.

Aims: The aim of this meta-analysis was to comprehensively evaluate the association of early age at natural menopause with the risk for all-cause and cardiovascular mortality.

Methods: Literature retrieval was done on August 4, 2020. Article selection and data extraction were completed independently and in duplicate.

The relationship between sleep duration and all-cause mortality in the older people: an updated and dose-response meta-analysis.

Background: Short or long sleep duration is proposed as a potential risk factor for all-cause mortality in the older people, yet the results of published studies are not often reproducible.

Methods: Literature retrieval, study selection and data extraction were completed independently and in duplicate. Only prospective cohort studies were included.