Comparative risk of QTc prolongation induced by second-generation antipsychotics in the real world: retrospective cohort study based on a hospital information system.

Background: Second-generation antipsychotics (SGAs) can cause corrected QT interval (QTc) prolongation as a side-effect. This may limit their clinical use and pose safety concerns for patients.

Aims: To analyse the risk of QTc prolongation associated with eight second-generation antipsychotics and observe the timing characteristics of QTc prolongation events and subsequent changes in medication strategies.

A pharmacovigilance study of olanzapine/samidorphan based on FDA Adverse Event Reporting System (FAERS).

Objects: The olanzapine/samidorphan (OLZ/SAM) combination is being regarded as a new strategy to combat weight gain induced by olanzapine (OLZ), and its safety is of significant concern. Specifically, as samidorphan is an opioid receptor-related drug, issues related to its potential for dependence and withdrawal symptoms deserve attention. This study aims to provide a comprehensive analysis of adverse events (AEs) associated with the OLZ/SAM.

Cutaneous toxicity induced by antidepressants and second-generation antipsychotics in the United States food and drug administration adverse event reporting system.

Background: Adverse cutaneous drug reactions have been reported with most drugs, including antidepressants (ADs) and second-generation antipsychotics (SGAs). The lack of extensive research on the relationship between ADs and SGAs, and cutaneous toxicity remains troubling. Our study aimed to assess the cutaneous toxicity of ADs and SGAs and provide valuable insights for clinical applications and scientific investigations.

[Carbon Emission Effects of Spatially Connected Networks in the Digital Economy： Dynamic Evolution and Mechanism of Action].

In the context of the "double carbon" goal and the construction of the "East Counts, West Counts" project, this study investigated the characteristics of the spatial and temporal evolution of the digital economy spatial correlation network, and the effects and mechanisms of carbon emission reduction and carbon rebound effects by selecting data at the level of 254 prefectural-level cities from 2011 to 2021 and using the UCINET software and empirical econometric modeling. The results indicated that： The spatial network of the digital economy represented the development pattern of multiple synergies and had the characteristics of non-equilibrium spatial evolution in geographic regions. Secondly, the spatial network of the digital economy in the sample selection period had a positive contribution to carbon emission reduction, and it led to the carbon rebound effect, which was still valid after the robustness test.

How does problem-solving pedagogy affect creativity? A meta-analysis of empirical studies.

The purpose of this study was to investigate the effects of problem-solving pedagogy on individual students' creativity in different teaching contexts and conditions, and to examine the role of moderating variables that may affect the overall effect size. The study screened 19 relevant studies from the Web of Science for inclusion in the meta-analysis, and extracted 77 effect sizes from these studies that could be used in the meta-analysis. The study first explored the relationship between problem-solving pedagogy and the development of learner creativity, and further analysis focused on moderating variables to investigate the effects of instructional method, grouping method, grade level, problem-solving scaffolding, source of problems, the application of thinking tools, and the application of technology.

Ornamental plants associated with Buddhist figures in China.

Background: In China, many ornamental plants associated with Buddhist figures, including the Sakyamuni, Bodhisattva, and Arhat, were grown and worshiped because of their cultural and religious significance. However, the systematic collation and ethnobotanical information about these culturally important plants have yet to be fully understood.

Methods: Online information was collected from 93 e-commercial platforms for ornamental plants all over China.

Weak Magnetic Internal Signal Characteristics of Pipe Welds under Internal Pressure.

Weak magnetic detection technology is an effective method to identify stress-induced damage to ferromagnetic materials, and it especially possesses great application potential in long-distance oil and gas pipeline weld crack detection. In the process of pipeline operation, due to internal pressure and external loads, local stress concentration may be generated, and partial stress concentration may lead to local cracks and expansion of the pipe. In order to improve the accuracy of magnetic signal analysis for ferromagnetic materials under internal pressure, the causes of magnetic signal generation at pipeline welds were analyzed from a microscopic perspective.

Long-Term Antipsychotic Effectiveness and Comparison of the Efficacy of Monotherapy and Polypharmacy in Schizophrenia: A 3-Years Follow-Up "Real World" Study in China.

Discontinuation of antipsychotic treatment is a common problem in patients with schizophrenia and could reduce the effectiveness of treatment. Time to discontinuation (TTD) is one of the indicators of compliance and may also be an effective indicator of medication efficacy. The aim of the study was to compare the clinical effectiveness of quetiapine, olanzapine, risperidone, and aripiprazole in the real-world treatment of schizophrenia with 3-years follow-up.

Case Report: Herpes Simplex Virus Type 2 Acute Retinal Necrosis With Viral Encephalitis in Children.

Background: Few cases concerning acute retinal necrosis with viral encephalitis in children have been reported, especially cases where the fundus cannot be identified due to severe vitreous opacity in the early stage that makes diagnosis difficult.

Methods: We conducted a retrospective review of an unusual case of herpes simplex virus-2 (HSV-2) acute retinal necrosis with viral encephalitis in an immunocompetent child, along with a review of relevant literature published up to September 2021.

Result: An 11-year-old girl presented with an approximate 20-day history of ocular redness and decreased visual acuity in the left eye.

Characteristics and Spectrum of Cardiotoxicity Induced by Various Antipsychotics: A Real-World Study From 2015 to 2020 Based on FAERS.

This study aimed to investigate the characteristics and spectrum of cardiotoxicity induced by various antipsychotics based on the United States Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) database. Data of the FAERS database from the first quarter of 2015 to the fourth quarter of 2020 were downloaded for disproportionality analysis. The significant signal was evaluated by reporting odds ratios and information components with statistical shrinkage transformation.

A Real-World Study of Risk Factors for QTc Prolongation in Schizophrenia Patients Receiving Atypical Antipsychotics.

Purpose: The risk of sudden cardiac death in patients receiving atypical antipsychotics may be related to QTc prolongation. The aim of this study was to investigate the risk factors for QTc prolongation to prevent QTc prolongation and guide clinical practice.

Methods: All electrocardiogram recordings of 913 schizophrenia patients who were receiving atypical antipsychotics were reviewed for prolonged QTc and associated conditions.

Research on Features of Pipeline Crack Signal Based on Weak Magnetic Method.

Quantitative online detection of microcracks in long-distance oil and gas pipelines is an international problem, and the effective detection method is still lacking. In this paper, a mathematical model of non-uniform distribution of crack magnetic charges is established based on the stress distribution laws of pipeline cracks under internal pressure. The weak magnetic signal characteristics of pipeline cracks with different sizes are analyzed.

Study on internal stress damage detection in long-distance oil and gas pipelines via weak magnetic method.

Weak magnetic stress detection is an important issue in oil-gas pipeline internal detection area. In order to verify the characteristics of weak magnetic stress internal detection signals, we built herein a magneto-mechanics equivalent model having a balanced magnetic field. First, we calculated the relationship between the stress and the weak magnetic signals; consequently, the analysis propagation laws of the weak magnetic signals with non-magnetic saturation were pointed out.