Quantum State Transfer between Superconducting Cavities via Exchange-Free Interactions.

We propose and experimentally demonstrate a novel protocol for transferring quantum states between superconducting cavities. This approach utilizes continuous two-mode squeezing interactions to generate entanglement without the exchange of any carrier photons. In contrast to the discrete operations of entanglement and Bell-state measurement in quantum teleportation, our scheme is symmetric and continuous.

Development of a quinic acid-induced CRISPR/Cas9 genome editing system and its application for the activation of ilicicolin H biosynthesis in Trichoderma reesei.

The CRISPR/Cas9 genome editing tool has been extensively utilized in filamentous fungi, including Trichoderma reesei. However, most existing systems employ constitutive promoters for the expression of Cas9 protein within the cells or directly introduce Cas9 protein into the cells, which often leads to continuous expression of Cas9 resulting in undesired phenotypes or increased operational cost. In this study, we identified a quinic acid (QA)-induced qai5 promoter and employed it to express Cas9, thereby establishing an inducible genome editing system in T.

Assessing the efficacy of hemoperfusion for dermatomyositis-associated acute exacerbation of interstitial pneumonia: a multicenter retrospective study.

Objectives: Hemoperfusion (HP) is used to treat various diseases, including sepsis and acute respiratory distress syndrome. However, few studies have explored the efficiency of HP in dermatomyositis-associated acute exacerbation of interstitial lung disease.

Methods: We conducted a retrospective study.

Study on the Dynamic Changes in Non-Volatile Metabolites of Rizhao Green Tea Based on Metabolomics.

The processing of tea leaves plays a crucial role in the formation of the taste of the resulting tea. In order to study the compositions of and changes in taste-related substances during the processing of Rizhao green tea, non-targeted metabolomics was used, based on UHPLC-Q Exactive MS. Totals of 529, 349, and 206 non-volatile metabolites were identified using three different detection modes, of which 112 secondary metabolites were significantly changed.

Deep quantum neural networks on a superconducting processor.

Deep learning and quantum computing have achieved dramatic progresses in recent years. The interplay between these two fast-growing fields gives rise to a new research frontier of quantum machine learning. In this work, we report an experimental demonstration of training deep quantum neural networks via the backpropagation algorithm with a six-qubit programmable superconducting processor.

Beating the break-even point with a discrete-variable-encoded logical qubit.

Quantum error correction (QEC) aims to protect logical qubits from noises by using the redundancy of a large Hilbert space, which allows errors to be detected and corrected in real time. In most QEC codes, a logical qubit is encoded in some discrete variables, for example photon numbers, so that the encoded quantum information can be unambiguously extracted after processing. Over the past decade, repetitive QEC has been demonstrated with various discrete-variable-encoded scenarios.

The regularity of nourishing-yin prescription for treating ascites due to hepatitis B cirrhosis based on data mining technology.

Background: Clinically, Chinese medicine is mostly used to treat ascites due to hepatitis B cirrhosis by nourishing-yin. We summarize the pattern of prescriptions for nourishing-yin inascites due to hepatitis B cirrhosis based on data mining to better use traditional Chinese medicine (TCM) to treat cirrhotic ascites in hepatitis B.

Methods: Articles published from 2000 to 2020 on ascites due to hepatitis B cirrhosis were searched in the Chinese National Knowledge Infrastructure and Chinese Science and Technology Journal Database.

An ultra-high gain single-photon transistor in the microwave regime.

A photonic transistor that can switch or amplify an optical signal with a single gate photon requires strong non-linear interaction at the single-photon level. Circuit quantum electrodynamics provides great flexibility to generate such an interaction, and thus could serve as an effective platform to realize a high-performance single-photon transistor. Here we demonstrate such a photonic transistor in the microwave regime.

A flying Schrödinger's cat in multipartite entangled states.

Schrödinger's cat originates from the famous thought experiment querying the counterintuitive quantum superposition of macroscopic objects. As a natural extension, several "cats" (quasi-classical objects) can be prepared into coherent quantum superposition states, which is known as multipartite cat states demonstrating quantum entanglement among macroscopically distinct objects. Here, we present a highly scalable approach to deterministically create flying multipartite Schrödinger's cat states by reflecting coherent-state photons from a microwave cavity containing a superconducting qubit.

Immunohistochemical Analysis of CYP11B2, CYP11B1 and β-catenin Helps Subtyping and Relates With Clinical Characteristics of Unilateral Primary Aldosteronism.

Primary aldosteronism is caused by aldosterone overproduction. While conventional hematoxylin-eosin staining can demonstrate morphological abnormality, it cannot provide any functional histopathological information. We aimed to identify the diagnostic, functional and prognostic value of CYP11B2, CYP11B1, and β-catenin immunostaining in unilateral hyperaldosteronism.

One-pot fabrication of lignin-based aromatic porous polymers for efficient removal of bisphenol AF from water.

To remove the bisphenol AF (BPAF) from aqueous solution, two different types of lignin-based aromatic porous polymers (LAPP-1 and LAPP-2) were fabricated via one-pot crosslinking of lignin with 1,4-dichloroxylene and 4,4'-bis(chloromethyl)-1,1'-biphenyl, respectively. The successful synthesis of LAPPs was confirmed by FTIR and XPS, SEM, TEM and N adsorption-desorption analysis. Then, batch adsorption experiments were conducted to investigate adsorption properties toward BPAF.

Influence of Body Mass Index on Survival and Prognosis in Squamous Cell Carcinoma of Head and Neck.

Objective: Differences in body mass index (BMI) were used to analyze the survival and prognosis of SCCHN patients.

Patients And Methods: A retrospective cohort study was conducted to select 323 patients who underwent surgical treatment for SCCHN from June 2013 to June 2016. The patients were divided into a healthy BMI group (BMI<24kg/m), an overweight group (24kg/m≤BMI<28kg/m) and an obese group (BMI≥28 kg/m).

Self-Assembled and Self-Monitored Sorafenib/Indocyanine Green Nanodrug with Synergistic Antitumor Activity Mediated by Hyperthermia and Reactive Oxygen Species-Induced Apoptosis.

Liver cancer is a leading cause of cancer morbidity and mortality worldwide, especially in China. Sorafenib (SRF) is currently the most commonly used systemic agent against advanced hepatocellular carcinoma (HCC), which is the most common type of liver cancer. However, HCC patients have only limited benefit and suffer a serious side effect from SRF.

Observation of Topological Magnon Insulator States in a Superconducting Circuit.

Searching topological states in artificial systems has recently become a rapidly growing field of research. Meanwhile, significant experimental progress on observing topological phenomena has been made in superconducting circuits. However, topological insulator states have not yet been reported in this system.

Quantum generative adversarial learning in a superconducting quantum circuit.

Generative adversarial learning is one of the most exciting recent breakthroughs in machine learning. It has shown splendid performance in a variety of challenging tasks such as image and video generation. More recently, a quantum version of generative adversarial learning has been theoretically proposed and shown to have the potential of exhibiting an exponential advantage over its classical counterpart.

Experimental repetitive quantum channel simulation.

Universal control of quantum systems is a major goal to be achieved for quantum information processing, which demands thorough understanding of fundamental quantum mechanics and promises applications of quantum technologies. So far, most studies concentrate on ideally isolated quantum systems governed by unitary evolutions, while practical quantum systems are open and described by quantum channels due to their inevitable coupling to environment. Here, we experimentally simulate arbitrary quantum channels for an open quantum system, i.

Comparison of a twice daily injection of insulin aspart 50 with insulin aspart 30 in patients with poorly controlled type 2 diabetes.

Objective: To compare the efficacy and safety of a twice daily injection of insulin aspart (BIAsp) 30 and BIAsp50 in patients with type 2 diabetes mellitus (T2DM) poorly controlled with oral hypoglycemic agents (OHAs).

Methods: In this 12 week prospective, randomized, parallel trial, a total of 80 T2DM patients, 59 ± 10 years old with a disease duration of 9.3 ± 6.

Simulation of molecular spectroscopy with circuit quantum electrodynamics.

Spectroscopy is a crucial laboratory technique for understanding quantum systems through their interactions with the electromagnetic radiation. Particularly, spectroscopy is capable of revealing the physical structure of molecules, leading to the development of the maser-the forerunner of the laser. However, real-world applications of molecular spectroscopy are mostly confined to equilibrium states, due to computational and technological constraints; a potential breakthrough can be achieved by utilizing the emerging technology of quantum simulation.

A twofold quantum delayed-choice experiment in a superconducting circuit.

Wave-particle complementarity lies at the heart of quantum mechanics. To illustrate this mysterious feature, Wheeler proposed the delayed-choice experiment, where a quantum system manifests the wave- or particle-like attribute, depending on the experimental arrangement, which is made after the system has entered the interferometer. In recent quantum delayed-choice experiments, these two complementary behaviors were simultaneously observed with a quantum interferometer in a superposition of being closed and open.

Specific On-site Assembly of Multifunctional Magnetic Nanocargos Based on Highly Efficient and Parallelized Bioconjugation: Toward Personalized Cancer Targeting Therapy.

The rational design of particle-based cancer theranostic agents, combining diagnostic and therapeutic features in a single entity, has emerged as an effective approach toward personalized cancer therapy; however, creating a flexible assembly of specific targeting ligands with regard to a broad range of tumor tissues and cells is still challenging. Here, we present a convenient and highly variable on-site assembly strategy for the preparation of multifunctional doxorubicin (DOX)-loaded nanocargos with magnetic supraparticles (MSPs) as a core and redox-degradable poly(methylacrylic acid-bis(acryloyl) cystamine) (P(MAACy) as the shell, which could be simultaneously modified with multiple targeting ligands through parallelized bioconjugation on the basis of a streptavidin-biotin (SA-BT) interaction. Under physiological conditions similar to those of the cytoplasm of tumor cells, DOX could be released in a controlled manner from these nanocargos to specific tumor sites, while dual-ligand modified nanocargos showed remarkable proliferation inhibition for the HeLa cells and the SK-OV-3 cells that overexpressed both folate as well as integrin receptors.

Synergistic Cisplatin/Doxorubicin Combination Chemotherapy for Multidrug-Resistant Cancer via Polymeric Nanogels Targeting Delivery.

Combination chemotherapy has been proposed to achieve synergistic effect and minimize drug dose for cancer treatment in clinic application. In this article, the stimuli-responsive polymeric nanogels (<100 nm in size) based on poly(acrylic acid) were designed as codelivery system for doxorubicin and cisplatin to overcome drug resistance. By chelation, electrostatic interaction, and π-π stacking interactions, the nanogels could encapsulate doxorubicin and cisplatin with designed ratio and high capacity.

Coulomb Oscillations in a Gate-Controlled Few-Layer Graphene Quantum Dot.

Graphene quantum dots could be an ideal host for spin qubits and thus have been extensively investigated based on graphene nanoribbons and etched nanostructures; however, edge and substrate-induced disorders severely limit device functionality. Here, we report the confinement of quantum dots in few-layer graphene with tunable barriers, defined by local strain and electrostatic gating. Transport measurements unambiguously reveal that confinement barriers are formed by inducing a band gap via the electrostatic gating together with local strain induced constriction.

Experimental Quantum Randomness Processing Using Superconducting Qubits.

Coherently manipulating multipartite quantum correlations leads to remarkable advantages in quantum information processing. A fundamental question is whether such quantum advantages persist only by exploiting multipartite correlations, such as entanglement. Recently, Dale, Jennings, and Rudolph negated the question by showing that a randomness processing, quantum Bernoulli factory, using quantum coherence, is strictly more powerful than the one with classical mechanics.