Publications by authors named "Luxiang Yang"
Neuroinflammation is a key factor in the development of preterm white matter injury (PWMI), leading to glial cell dysfunction, arrest of oligodendrocyte maturation, and long-term neurological damage. As a potential therapeutic strategy, mesenchymal stem cells (MSCs) exhibit significant immunomodulatory and regenerative potential. Recent studies suggest that the primary mechanism of MSC action is their paracrine effects, particularly mediated by extracellular vesicles, with MSC-derived exosomes (MSC-Exos) being the key mediators.
View Article and Find Full Text PDF[Effects of α1-antitrypsin on motor function in mice with immature brain white matter injury].
Zhongguo Dang Dai Er Ke Za Zhi
February 2024
Article Synopsis
- The study aimed to assess how α1-antitrypsin (AAT) affects motor function in adult mice suffering from white matter injury caused by hypoxia-ischemia.
- Mice were divided into three groups: sham surgery, hypoxia-ischemia with saline, and hypoxia-ischemia with AAT treatment, with various measurements taken at different intervals.
- Results indicated that mice receiving saline exhibited significant motor deficits compared to the sham group, while those treated with AAT showed improved motor function, suggesting potential therapeutic benefits of AAT for white matter injury.