Acute kidney injury in hospitalized adults with chronic kidney disease: comparing cROCK, KDIGO, and combined criteria.

Background: Acute-on-chronic kidney disease (ACKD) increases the risk of progression of chronic kidney disease (CKD). This study aimed to evaluate the ability of a novel criteria of reference change value of the serum creatinine optimized criteria for acute kidney injury in CKD (cROCK) to detect ACKD patients.

Methods: This was a retrospective observational study with a 3-year follow-up.

Degradation of Ubiquitin-Editing Enzyme A20 following Autophagy Activation Promotes RNF168 Nuclear Translocation and NF-κB Activation in Lupus Nephritis.

The correlation between ubiquitin-editing enzyme A20 and E3 ubiquitin ligase ring finger protein (RNF) 168 has been reported to be critical for repair of DNA damage. This study aimed to evaluate the potential role of this regulatory interaction in the pathogenesis of lupus nephritis (LN). The expression of RNF168 and A20 was measured in the podocytes derived from MRL/lpr murine lupus as well as patients with LN.

Prediction models for risk of diabetic kidney disease in Chinese patients with type 2 diabetes mellitus.

Background: Diabetic kidney disease (DKD) is a common and serious complication in patients with diabetic mellitus (DM), the risk of cardiovascular events and all-cause mortality also increases in DKD patients. This study aimed to detect the influencing factors of DKD in type 2 DM (T2DM) patients, and construct DKD prediction models and nomogram for clinical decision-making.

Methods: A total of 14,628 patients with T2DM were included.

Effect of different hemodialysis modalities on hepcidin clearance in patients undergoing maintenance hemodialysis.

Introduction: Hepcidin is a master regulator of iron utilization and takes part in the pathophysiology of anemia in maintenance hemodialysis (MHD) patients. Hepcidin is a moderate-molecular-weight substance and partially binds to plasma proteins in the circulation, which theoretically might be removed efficiently by hemoperfusion (HP). This study aimed to compare the effect of different dialysis modalities on hepcidin removal and discuss its effect on the iron and anemia status in MHD patients.

Serum Hepcidin-25 and All-Cause Mortality in Patients Undergoing Maintenance Hemodialysis.

Background: Hepcidin plays an important role in iron homeostasis, inhibits intestinal iron absorption and iron release from hepatocytes and macrophages, while its clinical utility remained unclear. This study aimed to investigate the associations between hepcidin-25 and mortality in MHD patients.

Methods: This was a prospective observational cohort of 161 MHD patients, with 2-year follow-up.

Analysis of Hemorrhagic Fever With Renal Syndrome Using Wavelet Tools in Mainland China, 2004-2019.

Hemorrhagic fever with renal syndrome (HFRS) is a life-threatening public health problem in China, accounting for ~90% of HFRS cases reported globally. Accurate analysis and prediction of the HFRS epidemic could help to establish effective preventive measures. In this study, the geographical information system (GIS) explored the spatiotemporal features of HFRS, the wavelet power spectrum (WPS) unfolded the cyclical fluctuation of HFRS, and the wavelet neural network (WNN) model predicted the trends of HFRS outbreaks in mainland China.

Meta-cresol degradation by persulfate through UV/O synergistic activation: Contribution of free radicals and degradation pathway.

The kinetic and pathway of meta-cresol (m-cresol) degradation were studied by persulfate oxidation through UV/ozone activation (UV/O-NaSO) to improve m-cresol removal to eliminate ecological risks. Experimental results showed that the degradation effect of m-cresol with an initial concentration of 50 mg/L was 99.8% in 30 min under the optimization conditions.

Comparison of bias and accuracy using cystatin C and creatinine in CKD-EPI equations for GFR estimation.

Background: The directly measured glomerular filtrate rate (mGFR) is the gold standard for kidney function, but it is invasive and costly. The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations have been widely used to estimate GFR, however, the comparative accuracy of estimated GFR (eGFR) using creatinine and cystatin C in CKD-EPI equations remains unclear. We performed this meta-analysis to assess the bias and accuracy of eGFR using equations of CKD-EPI, CKD-EPI, and CKD-EPI in adult populations relevant to primary health care.

Full-scale membrane bioreactor process WWTPs in East Taihu basin: Wastewater characteristics, energy consumption and sustainability.

Based on the collection and analysis of essential data from wastewater treatment plants (WWTPs) in recent ten years, the work provides the wastewater characteristics and energy consumption performance in full-scale membrane bioreactor (MBR) process in East Taihu basin, China. High-quality effluent was achieved although the influent carbon source was not beneficial to total nitrogen and total phosphorus removal. The average specific energy consumption (SEC) was 0.

Role of A20/TNFAIP3 deficiency in lupus nephritis in MRL/lpr mice.

Background: The activation of the nuclear factor-κB (NF-κB) signaling pathway gives rise to inflammation in the pathogenesis of lupus nephritis (LN), with A20 serving as a negative feedback regulator and ubiquitin C‑terminal hydrolase L1 (UCH-L1) acting as a downstream target protein. However, their roles in the mechanism of LN remain undetermined.

Methods: In the present study, the expression of A20 and UCH-L1, the activity of NF-κB and ubiquitin-proteasome system (UPS) were measured in MRL/lpr mice and A20 gene silenced podocytes.

Effect of Dialysate Glucose Concentration on Hepcidin Clearance in Maintenance Hemodialysis Patients.

Introduction: Hepcidin is a key regulator of iron homeostasis, takes part in pathophysiology of anemia and cardiovascular disease in maintenance hemodialysis (MHD) patients. The aim of this study was to compare the effect of glucose-free and glucose-containing dialysate on the clearance of hepcidin-25 during a hemodialysis (HD) session and discuss its potential mechanism in MHD patients.

Methods: In a longitudinal interventional study of 30 stable MHD patients without diabetes, we measured serum hepcidin-25 and plasma catecholamines (adrenaline, noradrenaline, and dopamine) during HD session using glucose-free dialysate and then switched to 5.

A20 overexpression exerts protective effects on podocyte injury in lupus nephritis by downregulating UCH-L1.

Lupus nephritis (LN), an autoimmune kidney disease caused by systemic lupus erythematosus (SLE), is the inflammation of the kidney. Although the treatment of LN is still a therapeutic challenge for many practitioners, the present study aims to provide a new insight for the treatment and management. The study aims to explore the effect of A20 on LN in relation to the nuclear factor-kappa B (NF-κB) signaling pathway.

Global diabetic kidney disease research from 2000 to 2017: A bibliometric analysis.

Background: This study aimed to analyze the scientific outputs of diabetic kidney disease (DKD) research and explore its hotspots and frontiers from 2000 to 2017, using bibliometric methods.

Methods: Articles in DKD research between 2000 and 2017 were retrieved from the Web of Science Core Collection (WoSCC). We used the VOSviewer 1.

Forecast post-dialysis blood pressure in hemodialysis patients with intradialytic hypertension.

: Intradialytic hypertension (IDH) is emerging as an important issue in maintenance hemodialysis (MHD) patients. This study aimed to discuss potential factors related to IDH and build forecasting models for post-dialysis blood pressure (BP) in MHD patients with IDH. : A total of 266 MHD patients were enrolled, included 133 (50%) patients with IDH and 133 patients without IDH.

Spatiotemporal analysis and forecasting model of hemorrhagic fever with renal syndrome in mainland China.

Hemorrhagic fever with renal syndrome (HFRS) caused by hantaviruses is a serious public health problem in China, accounting for 90% of HFRS cases reported globally. In this study, we applied geographical information system (GIS), spatial autocorrelation analyses and a seasonal autoregressive-integrated moving average (SARIMA) model to describe and predict HFRS epidemic with the objective of monitoring and forecasting HFRS in mainland China. Chinese HFRS data from 2004 to 2016 were obtained from National Infectious Diseases Reporting System (NIDRS) database and Chinese Centre for Disease Control and Prevention (CDC).

Mucin 4 Gene Silencing Reduces Oxidative Stress and Calcium Oxalate Crystal Formation in Renal Tubular Epithelial Cells Through the Extracellular Signal-Regulated Kinase Signaling Pathway in Nephrolithiasis Rat Model.

Background/aims: Nephrolithiasis plagues a great number of patients all over the world. Increasing evidence shows that the extracellular signal-regulated kinase (ERK) signaling pathway and renal tubular epithelial cell (RTEC) dysfunction and attrition are central to the pathogenesis of kidney diseases. Mucin 4 (MUC4) is reported as an activator of ERK signaling pathway in epithelial cells.

Make Precision Medicine Work for Chronic Kidney Disease.

Precision medicine is based on accurate diagnosis and tailored intervention through the use of omics and clinical data together with epidemiology and environmental exposures. Precision medicine should be achieved with minimum adverse events and maximum efficacy in patients with chronic kidney disease (CKD). In this review, the breakthroughs of omics in CKD and the application of systems biology are reviewed.

Forecast of the incidence, prevalence and burden of end-stage renal disease in Nanjing, China to the Year 2025.

Background: There are limited data on the trends of incidence or prevalence of end stage renal disease (ESRD) in China. To assist in future planning for the ESRD program, the trends of incidence, prevalence and health care costs were analyzed and forecasted to the year 2025 by modeling of historical data from 2004 through 2014.

Methods: Nanjing urban employee basic medical insurance (NJUEBMI) data were obtained from the Nanjing Medical Insurance Information System from 2004 to 2014.

Haemorrhagic fever with renal syndrome: literature review and distribution analysis in China.

Hantaviruses infect their reservoir hosts and humans, but the infection only causes disease in humans. In Asia and Europe (the Old World), the hantaviruses usually cause haemorrhagic fever with renal syndrome (HFRS). This article summarizes the current understanding of hantavirus epidemiology, as well as the clinical manifestations, pathogenesis, renal pathology, diagnosis, treatment, and prevention of HFRS.

Meta-analysis of statin therapy in maintenance dialysis patients.

The effects of statin therapy in patients on maintenance dialysis remained uncertain. We conducted a meta-analysis to investigate the effects of statin on major clinical outcomes. We systematically searched Pubmed, Web of Science, Cochrane Library, Chinese National Knowledge Infrastructure, Wanfang and Chinese Technological Journal of Database for randomized controlled trials (RCTs).