Role of covalent modification by hepatic aldehydes in dictamnine-induced liver injury.

Dictamnine is a representative furan-containing hepatotoxic compound. Administration of dictamnine caused acute liver injury in mice and the metabolic activation of furan to reactive epoxy intermediate was responsible for the hepatotoxicity. This study aimed to characterize the protein adduction by endogenous hepatic aldehydes and investigate its role in dictamnine-induced hepatotoxicity.

Equity and efficiency of maternal and child health resources allocation in Hunan Province, China.

Background: A reasonable allocation of health resources is often characterized by equity and high efficiency. This study aims to evaluate the equity and efficiency of maternal and child health (MCH) resources allocation in Hunan Province, China.

Methods: Data related to MCH resources and services was obtained from the Hunan maternal and child health information reporting and management system.

[Direct sequencing and analysis of exons of Wilson' disease gene with the most mutations: a study in Hunan Han patients].

Objective: To detect hot point mutations of ATP7B gene in Hunan Han patients with Wilson' disease (WD).

Methods: The genomic DNA of 22 WD patients was extracted and exons 5, 8, 12, 13 were amplified by PCR. Screening for the mutations was done by direct sequencing and analysed by BLAST.

[Effect of lamivudine treatment on the quality of life of chronic hepatitis B].

Objective: To assess the quality of life of 3 types of chronic hepatitis B before and after the treatment of lamivudine, and to find an ideal way of medical treatment for chronic hepatitis B.

Methods: One hundred and fifty patients with chronic hepatitis B were investigated in this study, among whom 5 1 were in mild state illness, 53 were middle-range and the other 46 were severe. The quality of life of the patients was assessed by the quality of life questionnaire (SF-36).

[Short-term effect evaluation of health education on the prevention of AIDS among university students in Changsha].

Objective: To survey the sexual sense and AIDS knowledge and to evaluate the instant effect of health education for university students in Changsha.

Methods: According to the KABP survey, 235 students in 2 universities in Changsha were investigated by anonymous questionnaires before and after the health education. The health education on sex and AIDS knowledge was carried out by a professor from an AIDS laboratory.