The Associations of Erythrocyte Fatty Acids with Whole Blood Mineral Elements in Children.

Background. Minerals play important biological roles in lipid metabolism. The primary aim of this study was to examine the relationships between erythrocyte fatty acids (FAs) levels with whole blood mineral elements concentrations among Chinese children.

Abiraterone and MDV3100 inhibits the proliferation and promotes the apoptosis of prostate cancer cells through mitophagy.

Background: Abiraterone and MDV3100 are two effective anticancer agents for prostate cancer, however, the mechanism of their downstream action remains undefined.

Methods: A dual fluorescent biosensor plasmid was transfected in LNCaP cells to measure mitophagy. The DNA of LNCaP cells was extracted and performed with quantitative real-time PCR to detect mitochondrial DNA copy number.

Androgen upregulates the palmitoylation of eIF3L in human prostate LNCaP cells.

Prostate cancer is the second leading cause of cancer-related deaths in Western countries. Most patients diagnosed with advanced prostate cancer can be treated with the main treatment: androgen deprivation therapy (ADT). The androgen receptor (AR) signaling axis plays a pivotal role in the progression of prostate cancer.

Spatial Intratumor Genomic Heterogeneity within Localized Prostate Cancer Revealed by Single-nucleus Sequencing.

Background: Prostate adenocarcinoma (PCa) is a complex genetic disease, and the implementation of personalized treatment in PCa faces challenges due to significant inter- and intrapatient tumor heterogeneities.

Objective: To systematically explore the genomic complexity of tumor cells with different Gleason scores (GSs) in PCa.

Design, Setting, And Participants: We performed single-cell whole genome sequencing of 17 tumor cells from localized lesions with distinct GS and matched four normal samples from two prostatectomy patients.