Neuroimaging in pregnancy: a review of clinical indications and obstetric outcomes.

Objective: To determine indications and outcomes of pregnant women requiring neurologic imaging at a tertiary care center.

Methods: We reviewed medical records of women receiving magnetic resonance (MR) head imaging during pregnancy to determine indications for such imaging and their pregnancy outcomes.

Results: Between April 2007 and December 2008, 60 pregnant women presented to Brigham and Women's Hospital with severe headache or other acute neurologic complaint and underwent head imaging.

Endometrial intraepithelial neoplasia: clinical correlates and outcomes.

Objective: To estimate cancer outcome and outcome predictors of women with endometrial intraepithelial neoplasia (EIN).

Methods: Outcomes of women with first diagnosis of EIN ("index biopsy") were determined by follow-up pathology. Patient characteristics were correlated with EIN regression, EIN persistence, and progression to cancer.

Identifying the molecular signature of the interstitial deletion 7q subgroup of uterine leiomyomata using a paired analysis.

Uterine leiomyomata (UL), the most common neoplasm in reproductive-age women, have recurrent cytogenetic abnormalities including interstitial deletion of 7q. To develop a molecular signature, matched del(7q) and non-del(7q) tumors identified by FISH or karyotyping from 11 women were profiled with expression arrays. Our analysis using paired t tests demonstrates this matched design is critical to eliminate the confounding effects of genotype and environment that underlie patient variation.

Comparative evaluation of accuracy of extraction of medication information from narrative physician notes by commercial and academic natural language processing software packages.

Medication information is frequently only found in narrative physician notes. It is now possible to extract medication data from narrative documents using NLP technology. A number of commercial and academic NLP software packages can perform this function.