Anti-Dengue Screening on Several Vietnamese Medicinal Plants: Experimental Evidences and Computational Analyses.

Worldwide, medicinal plants have been known for economic and geographical advantages, thus possibly holding potentiality against dengue hemorrhagic fever. The methanol/water extracts from different parts of fourteen Vietnam-based plant species were subjected for experimental screening on anti-dengue activity using baby hamster kidney cells (BHK21) and plaque reduction neutralisation test (PRNT). Firstly, the methanol/water extracts were tested against serotype dengue virus DENV-1.

Two new glycosides, farnesyl pentaglycoside and oleanane triglycoside from , a mangrove plant collected from Thua Thien-Hue province, Vietnam.

Phytochemical investigation of the leaves of led to the isolation of two new glycosides, lepisantheside A () and lepisantheside B (), together with two known compounds acutoside A () and 3-O-[-D-xylopyranosyl-(1→3)--D-glucopyranosyl-]-oleanolic acid (. Their structures were elucidated by means of spectroscopic methods (HR-ESI-MS, 1D and 2D NMR), and by comparison with the reported data. The cytotoxicity of compounds against four human cancer cell lines (KB, HepG2, SK-LU-1 and MCF7) was evaluated.