Adolescent Blood Pressure and Early Age Stroke.

Background: Underdiagnosis of relevant risk factors has contributed to the increasing stroke incidence in young adults. Blood pressure cut-off values for adolescents are neither sex specific nor based on cardiovascular outcomes.

Methods: This nationwide, population-based, retrospective cohort study included all Israeli adolescents 16-19 years of age who were medically evaluated before compulsory military service from 1985 to 2013, including routine blood pressure measurements.

Cognitive function in adolescence and the risk of early-onset stroke.

Background: Stroke is increasingly prevalent at younger ages but the risk factors are uncertain. We examined the association between adolescent cognitive function and early-onset stroke.

Methods: This was a nationwide population-based cohort study of 1 741 345 Israeli adolescents (42% women) who underwent comprehensive cognitive function tests at age 16-20 years, before mandatory military service, during 1987-2012.

Identifying Diabetes Related-Complications in a Real-World Free-Text Electronic Medical Records in Hebrew Using Natural Language Processing Techniques.

Background: Studies have demonstrated that 50% to 80% of patients do not receive an International Classification of Diseases (ICD) code assigned to their medical encounter or condition. For these patients, their clinical information is mostly recorded as unstructured free-text narrative data in the medical record without standardized coding or extraction of structured data elements. Leumit Health Services (LHS) in collaboration with the Israeli Ministry of Health (MoH) conducted this study using electronic medical records (EMRs) to systematically extract meaningful clinical information about people with diabetes from the unstructured free-text notes.

Adolescent Hypertension Is Associated With Stroke in Young Adulthood: A Nationwide Cohort of 1.9 Million Adolescents.

Background: Adult hypertension is a well-established risk factor for stroke in young adults (aged <55 years), and the effects are even more deleterious than at an older age. However, data are limited regarding the association between adolescent hypertension and the risk of stroke in young adulthood.

Methods: A nationwide, retrospective cohort study of adolescents (aged 16-19 years) who were medically evaluated before compulsory military service in Israel during 1985 to 2013.

Hospitalizations in older-adults newly diagnosed with dementia: A population-based longitudinal study in Israel.

Objectives: To compare inpatient burden (i.e. likelihood of hospitalization, number of admissions and length of stay) in persons with newly diagnosed dementia to the general population without dementia.

Peripheral sensory nerve function, type 2 diabetes and frailty among men with cardiovascular disease.

Objective: To investigated the cross-sectional association between peripheral sensory nerve function and frailty among community-dwelling men, and examine whether type 2 diabetes (T2D) modifies this association.

Methods: A sample of 349 men [mean age = 77.1 ± 6.

Obesity in late adolescence and incident type 1 diabetes in young adulthood.

Aims/hypothesis: Studies in children have reported an association between increased BMI and risk for developing type 1 diabetes, but evidence in late adolescence is limited. We studied the association between BMI in late adolescence and incident type 1 diabetes in young adulthood.

Methods: All Israeli adolescents, ages 16-19 years, undergoing medical evaluation in preparation for mandatory military conscription between January 1996 and December 2016 were included for analysis unless they had a history of dysglycaemia.

Prevalence and Incidence Rates of Dementia: A Nationwide Population-Based Study of Electronic Health Records in Israel.

Background: Data on the rate of dementia is essential for planning and developing appropriate services at the national level.

Objective: We report the prevalence and incidence of dementia, based on electronic health records available for the whole population.

Methods: This national dementia dataset was established as a part of the National Program to Address Alzheimer's and Other Types of Dementia.

Adolescent cognitive function and incident early-onset type 2 diabetes.

Background: Cognitive function among apparently healthy adolescents has been associated with cardiovascular morbidity and mortality. We examined the relationship between global and subdomain cognitive scores in adolescence and early-onset type 2 diabetes (T2D) in men and women.

Methods: A nationwide, population-based study of 971,677 Israeli born adolescents (56% men; mean age 17.

Myopia and Early-Onset Type 2 Diabetes: A Nationwide Cohort Study.

Context: A correlation between myopia and insulin resistance has been suggested.

Objective: We investigated the association between myopia in adolescence and type 2 diabetes (T2D) incidence in young adulthood.

Methods: This population-based, retrospective, cohort study comprised 1 329 705 adolescents (579 543 women, 43.

Asthma in Youth and Early-onset Type 2 Diabetes: A Nationwide Study of 1.72 Million Israeli Adolescents.

Background: The prevalence of both asthma and early-onset diabetes is on the rise; however, the association between them remains unclear. We examined a possible association of asthma at adolescence with type 2 diabetes in young adulthood.

Methods: This is a nationwide, population-based study of 1 718 541 Israeli adolescents (57% males; mean age 17.

Machine learning based study of longitudinal HbA1c trends and their association with all-cause mortality: Analyses from a National Diabetes Registry.

Objective: The association of long-term HbA1c variability with mortality has been previously suggested. However, the significance of HbA1c variability and trends in different age and HbA1c categories is unclear.

Research Design And Methods: Data on patients with diabetes listed in the Israeli National Diabetes Registry during years 2012-2016 (observation period) were collected.

Adolescent Thyroid Disorders and Risk for Type 2 Diabetes in Young Adulthood.

Context: Thyroid hormones play a key role in systemic metabolism, yet the relationship between thyroid dysfunction and risk for type 2 diabetes is unclear.

Objective: To assess type 2 diabetes risk in adulthood among adolescents with thyroid disorders.

Design And Setting: A nationwide, population-based study of Israeli adolescents who were examined before military recruitment during 1988 to 2007 and were followed until December 31, 2016.

Falls and fear of falling among Israeli community-dwelling older people: a cross-sectional national survey.

Background: Falls and fear of falling are a major problem for older people and a leading cause of functional decline and institutionalization. There is limited data on the prevalence of falls in a 12-month period among Israeli older adults. Our main objective was to evaluate the prevalence of falls among Israeli community-dwelling older people aged ≥65 years and to identify factors associated with falls and fear of falling.

Stuttering and Incident Type 2 Diabetes: A Population-Based Study of 2.2 Million Adolescents.

Purpose: To investigate the association between stuttering in adolescence and incident type 2 diabetes in young adulthood.

Methods: This nationwide population-based study included 2 193 855 adolescents of age 16 to 20 years who were assessed for military service between 1980 and 2013. Diagnoses of stuttering in adolescence were confirmed by a speech-language pathologist.

Holocaust exposure and late-life cognitive performance in men with coronary heart disease.

Background: Holocaust victims experienced extreme physical and mental stress that could lead to prolonged deficits in psychological and physiological well-being. We aimed to examine whether exposure to Holocaust conditions is associated with cognitive function and decline in a sample of old male adults with coronary heart disease (CHD).

Methods: The sample included 346 individuals with CHD who participated in a clinical trial in 1990-1997 (mean age 56.

Overweight, Obesity, and Late-Life Sarcopenia Among Men With Cardiovascular Disease, Israel.

Introduction: Little is known about the association between obesity and sarcopenia - age-related loss of muscle mass and function - among patients with cardiovascular disease. We investigated the association between overweight, obesity, and sarcopenia among community-dwelling men in Israel with cardiovascular disease.

Methods: A subset of 337 men (mean age at baseline 56.

A COVID-19 call center for healthcare providers: dealing with rapidly evolving health policy guidelines.

Background: Communication between health authorities and healthcare providers is an essential element of the response to public health emergencies. Although call centers can facilitate such communication, no published reports describing their outcomes exist. In advance of the expected COVID-19 outbreak in Israel, the Israel Center for Disease Control established a call center dedicated to queries from healthcare professionals.

Adolescent Nonalcoholic Fatty Liver Disease and Type 2 Diabetes in Young Adulthood.

Context: The long-term risk of type 2 diabetes in adolescents with nonalcoholic fatty liver disease (NAFLD) is unclear.

Objective: To assess type 2 diabetes risk among adolescents with NAFLD.

Design And Setting: A nationwide, population-based study of Israeli adolescents who were examined before military service during 1997-2011 and were followed until December 31, 2016.

Adolescent BMI and early-onset type 2 diabetes among Ethiopian immigrants and their descendants: a nationwide study.

Background: We assessed in a nationwide cohort the association between adolescent BMI and early-onset (< 40 years) type 2 diabetes among Israelis of Ethiopian origin.

Methods: Normoglycemic adolescents (range 16-20 years old), including 93,806 native Israelis (≥ 3rd generation in Israel) and 27,684 Israelis of Ethiopian origin, were medically assessed for military service between 1996 and 2011. Weight and height were measured.

Adolescent Obesity and Early-Onset Type 2 Diabetes.

Objective: Type 2 diabetes (T2D) is increasingly diagnosed at younger ages. We investigated the association of adolescent obesity with incident T2D at early adulthood.

Research Design And Methods: A nationwide, population-based study evaluated 1,462,362 adolescents (59% men, mean age 17.

Adherence to Mediterranean diet and subsequent cognitive decline in men with cardiovascular disease.

Evidence from recent years highlighted the importance of the Mediterranean diet for brain health. We investigated the association between adherence to Mediterranean diet and change in cognitive functions two decades later in patients with cardiovascular disease (CVD). Participants were men with a history of CVD, who previously participated in the Bezafibrate Infarction Prevention (BIP) trial between 1990 and 1997, had a food diary record, and underwent cognitive evaluations 14.

C-reactive protein in midlife is associated with depressive symptoms two decades later among men with coronary heart disease.

We investigated the relationship between midlife C-reactive protein (CRP) levels in men with coronary heart disease (CHD) and depressive symptoms at old age. CRP levels were measured in a subset of patients with CHD, who previously participated in a secondary prevention trial. Depressive symptoms were evaluated in survivors of the original cohort 15.

Childhood Pancreatitis and Risk for Incident Diabetes in Adulthood.

Objective: The relationship between acute pancreatitis and incident diabetes is unclear. We assessed whether a resolved single event of acute pancreatitis in childhood was associated with incident diabetes in adulthood.

Research Design And Methods: A nationwide, population-based study of 1,802,110 Israeli adolescents (mean age 17.