Computational psychiatry approach to stigma subtyping in patients with mental disorders: explicit and implicit internalized stigma.

Background: Psychiatric stigma has potentially controversial effects on patients health-related behaviors. It appears that both stigmatization and motivation in psychiatric patients are heterogeneous and multi-dimensional, and that the relationship between stigma and treatment motivation may be more complex than previously believed.

Aim: To determine psychiatric stigma subtypes as they relate to treatment motivation among inpatients with various mental disorders.

Determinants of Stress Levels and Behavioral Reactions in Individuals With Affective or Anxiety Disorders During the COVID-19 Pandemic in Russia.

Introduction: Individuals with affective and anxiety disorders are among those most vulnerable to the negative effects of the COVID-19 pandemic.

Aim: This study aims to analyze the determinants of stress levels and protective behavioral strategies associated with the COVID-19 pandemic in Russian-speaking people with affective or anxiety disorders (AADs).

Materials And Methods: In this cross-sectional online survey, the psychological distress and behavioral patterns of respondents with self-reported AAD ( = 1,375) and without disorders ( = 4,278) were evaluated during three periods of restrictive measures in Russia (March-May 2020).

[Antipsychotic selection strategies: the need for a holistic approach].

Objective: To describe the connections between strategies for antipsychotic prescribing and clinical, socio-psychological factors of treatment adherence in patients with psychotic disorders.

Material And Methods: The study included 83 inpatients with schizophrenic spectrum disorders (F2x) - 67%, affective disorders (F3x) - 15%, neurotic and personality (F4x + F6x) - 9%, organic diseases of the central nervous system (F0x) - 9%. We used a visual analog scale for patients' subjective severity of their condition, locus control test, Internalized stigma of mental disorder scale (ISMI), Treatment motivation assessment questionnaire (TMAQ), and Medication Compliance Scale (MCS), which also includes BPRS, SANS, GAF scales.

Behavioral and Emotional Reactions of the Russian Population to the Beginning of the COVID-19 Pandemic: An On-Line Survey Results.

Background: The study aimed to identify the patterns of adaptive and behavioral strategies in different population groups, also to evaluate their association with the infection prevention strategies and the distress during the COVID-19 pandemic.

Methods: The data were obtained from the on-line survey of 1958 respondents (mean age 31±12 years) from March 30, 2020 to April 5, 2020. 578 respondents reported a history of affective disorders; 884 respondents - a history of somatic disease.

Revisiting Drug Compliance: The Need for a Holistic Approach in the Treatment of Severe Mental Disorders.

Introduction: The limited practice of depot antipsychotics and psychoeducation use, recommended for overcoming the noncompliance of patients with severe mental disorders, is linked to a high incidence of treatment violation. Therefore, the development of personalized mental healthcare approaches is a crucial healthcare task.

Aim: To describe and differentiate the role of clinical, social and psychological factors that lead to different level of treatment engagement of psychiatric inpatients.

Stress and Stigmatization in Health-Care Workers during the COVID-19 Pandemic.

Background: The health-care workers showed the highest risks of the adverse psychological reactions from the COVID-19 pandemic.

Aim: This study aimed to evaluate the structure and severity of psychological distress and stigmatization in different categories of health-care workers during the COVID-19 pandemic.

Materials And Methods: This study included two phases of online survey in 1800 Russian-speaking health-care workers (March 30 - April 5 and May 4 - May 10, 2020).

[A role of motivation for treatment in the structure of compliance in psychopharmacologically treated patients].

Objective: To reveal an impact of specific motivation structures on the compliance in psychiatric inpatients.

Material And Methods: The Treatment Motivation Questionnaire and the Medication Compliance Scale have been administered to 104 patients, including 67 patients with schizophrenia and schizophrenia-spectrum disorders, 15 with affective disorders, 13 with personality and neurotic disorders and 9 with organic disorders, of the department of integrative pharmaco- and psychotherapy.

Results: A motivational mechanism based on the subjective suffering from disease plays a key role in the formation of overall score of compliance.

[The application of long-acting injectable antipsychotics in clinical practice (overcoming of obstacles)].

Objective: To explore the patients' attitudes towards the long-acting injectable antipsychotics.

Material And Methods: Authors surveyed 164 psychotic outpatients.

Results: Psychiatrists suggested long-acting injectable antipsychotics to 59.

[Lipid metabolism characteristics in disabled persons as a consequence of cerebrovascular diseases].

Lipid metabolism condition in young, mature (till 35 y.o) and elderly disabled persons as a consequence of cerebral diseases has been investigated. It was established that all three groups differ in clinical presentation and various kinds of lipid metabolism abnormalities.

[Proteolytic system in lungs upon inhalation exposure to low doses of lead salts].

Changes in proteinase--antiproteinase activities in lungs as a result of short-term (for 1 week) inhalation of rats with 0.01% (CH3COO)2 Pb have wholly compensative patterns, but it have been found increased cathepsine B activity as a negative prognostic factor. Chronic (for 2 month) toxicant inhalation caused considerable activation of both trypsine and cathepsine B under decreasing alpha 1-antitrypsine and alpha 2-macroglobuline activities.