Intercellular adhesion molecule-1 (ICAM-1): From molecular functions to clinical applications in cancer investigation.

Intercellular adhesion molecule-1 (ICAM-1) is a versatile molecule that plays a critical role in various physiological and pathological processes, particularly in tumor development where its impact is bidirectional. On the one hand, it augments the immune response by promoting immune cell migration, infiltration, and the formation of immunological synapses, thus facilitating potent antitumor effects. Simultaneously, it contributes to tumor immune evasion and influences metastasis by mediating transendothelial migration (TEM), epithelial-to-mesenchymal transition (EMT), and epigenetic modification of tumor cells.

Immune checkpoint inhibitors rechallenge in non-small cell lung cancer: Current evidence and future directions.

Immunotherapy, remarkably immune checkpoint inhibitors (ICIs), has significantly altered the treatment landscape for non-small cell lung cancer (NSCLC). Despite their success, the discontinuation of ICIs therapy may occur due to factors such as prior treatment completion, disease progression during ICIs treatment, or immune-related adverse events (irAEs). As numerous studies highlight the dynamic nature of immune responses and the sustained benefits of ICIs, ICIs rechallenge has become an attractive and feasible option.

Demonstration of 4H-silicon carbide on an aluminum nitride integrated photonic platform.

The existing silicon-carbide-on-insulator photonic platform utilizes a thin layer of silicon dioxide under silicon carbide (SiC) to provide optical confinement and mode isolation. Here, we replace the underneath silicon dioxide layer with 1-µm-thick aluminum nitride and demonstrate a 4H-silicon-carbide-on-aluminum-nitride integrated photonic platform for the first time to our knowledge. Efficient grating couplers, low-loss waveguides, and compact microring resonators with intrinsic quality factors up to 210,000 are fabricated.

Highly efficient single-layer graphene electro-absorption modulator.

We propose a single-layer graphene electro-absorption modulator (EAM) with an angled waveguide sidewall. By utilizing the hybridization of the TM mode and the TE mode in the waveguide, the light-graphene interaction is enhanced. A modulation depth of 0.

Investigation of the electro-optic effect in high-Q 4H-SiC microresonators.

Silicon carbide (SiC) recently emerged as a promising photonic and quantum material owing to its unique material properties. In this work, we carried out an exploratory investigation of the Pockels effect in high-quality-factor (high-Q) 4H-SiC microresonators and demonstrated gigahertz-level electro-optic modulation for the first time. The extracted Pockels coefficients show certain variations among 4H-SiC wafers from different manufacturers, with the magnitudes of and estimated to be in the range of (0.

Low-loss waveguides on Y-cut thin film lithium niobate: towards acousto-optic applications.

We investigate the dependence of photonic waveguide propagation loss on the thickness of the buried oxide layer in Y-cut lithium niobate on insulator substrate to identify trade-offs between optical losses and electromechanical coupling of surface acoustic wave (SAW) devices for acousto-optic applications. Simulations show that a thicker oxide layer reduces the waveguide loss but lowers the electromechanical coupling coefficient of the SAW device. Optical racetrack resonators with different lengths were fabricated by argon plasma etching to experimentally extract waveguide losses.

Novel on chip rotation detection based on the acousto-optic effect in surface acoustic wave gyroscopes.

An Acousto-Optic Gyroscope (AOG) consisting of a photonic integrated device embedded into two inherently matched piezoelectric surface acoustic wave (SAW) resonators sharing the same acoustic cavity is presented. This constitutes the first demonstration of a micromachined strain-based optomechanical gyroscope that uses the effective index of the optical waveguide due to the acousto-optic effect rather than conventional displacement sensing. The theoretical analysis comparing various photonic phase sensing techniques is presented and verified experimentally for the cases based on a Mach-Zehnder interferometer, as well as a racetrack resonator.

Highly efficient broadband second harmonic generation mediated by mode hybridization and nonlinearity patterning in compact fiber-integrated lithium niobate nano-waveguides.

The inherent trade-off between efficiency and bandwidth of three-wave mixing processes in χ nonlinear waveguides is the major impediment for scaling down many well-established frequency conversion schemes onto the level of integrated photonic circuit. Here, we show that hybridization between modes of a silica microfiber and a LiNbO nanowaveguide, amalgamated with laminar χ patterning, offers an elegant approach for engineering broadband phase matching and high efficiency of three-wave mixing processes in an ultra-compact and natively fiber-integrated setup. We demonstrate exceptionally high normalized second harmonic generation (SHG) efficiency of up to η ≈ 460% W cm, combined with a large phase matching bandwidth of Δλ ≈ 100 nm (bandwidth-length product of Δλ · L ≈ 5 μm) near the telecom bands, and extraordinary adjustment flexibility.

Electric-optical property of the proton exchanged phase modulator in single-crystal lithium niobate thin film.

The electric-optical property of the proton exchanged phase modulator in an x-cut single-crystal lithium niobate thin film was studied. Proton exchanged waveguides generally suffered from a deteriorated electric-optical coefficient. By introducing a shallow proton exchange layer (thickness = 0.

Channel waveguides and y-junctions in x-cut single-crystal lithium niobate thin film.

Proton exchanged channel waveguides in x-cut single-crystal lithium niobate thin film could avoid optical leakage loss which existed in the z-cut case. Indicated by simulations, the mechanism and condition of the optical leakage loss were studied. The light energy in the exchanged layer and the mode sizes were calculated to optimize the parameters for fabrication.

Waveguides consisting of single-crystal lithium niobate thin film and oxidized titanium stripe.

Strip-loaded waveguides were fabricated by the direct oxidation of a titanium film based on the single-crystal lithium niobate. The method avoided the surface roughness problems that are normally introduced during dry etching of waveguide sidewalls. Propagation modes of the composite strip waveguide were analyzed by a full-vectorial finite difference method.

Low-loss waveguides in a single-crystal lithium niobate thin film.

We report low-loss channel waveguides in a single-crystal LiNbO(3) thin film achieved using the annealed proton exchange process. The simulation indicated that the mode size of the α phase channel waveguide could be as small as 1.2  μm(2).

A sensitive protein-based sensor for quantifying histone acetylation levels.

H3K14ac (acetylation of lysine 14 of histone H3) is one of the most important epigenetic modifications in cells. Aberrant changes in H3K14ac are commonly found in various types of cancers and neurological disorders. Current detection approaches for histone modifications, however, require either tedious sample pre-treatments or lack the quantitative accuracy required for biochemical and biomedical applications.

Waveguides in single-crystal lithium niobate thin film by proton exchange.

The proton exchanged (PE) planar and channel waveguides in a 500 nm thick single-crystal lithium niobate thin film (lithium niobate on insulator, LNOI) were studied. The mature PE technique and strong confinement of light in the LN single-crystal thin film were used. The single mode and cut-off conditions of the channel waveguides were obtained by finite difference simulation.

Photonic crystal slab fabricated on the platform of lithium niobate-on-insulator.

We report on a photonic crystal slab patterned on a 690 nm thick LiNbO3 thin film bonded to SiO2 on lithium niobate substrate. The transmission spectrum is measured and a broad and clear photonic bandgap ranging from 1335 to 1535 nm with a maximum extinction ratio of more than 20 dB is observed. The bandgap is simulated by plane wave expansion and 3D finite-difference time-domain methods.