Time Refraction and Time Reflection above Critical Angle for Total Internal Reflection.

We study the time reflection and time refraction of waves caused by a spatial interface with a medium undergoing a sudden temporal change in permittivity. We show that monochromatic waves are transformed into a pulse by the permittivity change, and that time reflection is enhanced at the vicinity of the critical angle for total internal reflection. In this regime, we find that the evanescent field is transformed into a propagating pulse by the sudden change in permittivity.

Multi-dimensional band structure spectroscopy in the synthetic frequency dimension.

The concept of synthetic dimensions in photonics provides a versatile platform in exploring multi-dimensional physics. Many of these physics are characterized by band structures in more than one dimensions. Existing efforts on band structure measurements in the photonic synthetic frequency dimension however are limited to either one-dimensional Brillouin zones or one-dimensional subsets of multi-dimensional Brillouin zones.

Photonic time-crystals - fundamental concepts [Invited].

Photonic Time-Crystals (PTCs) are materials in which the refractive index varies periodically and abruptly in time. This medium exhibits unusual properties such as momentum bands separated by gaps within which waves can be amplified exponentially, extracting energy from the modulation. This article provides a brief review on the concepts underlying PTCs, formulates the vision and discusses the challenges.

Photonic time crystals: a materials perspective [Invited].

Recent advances in ultrafast, large-modulation photonic materials have opened the door to many new areas of research. One specific example is the exciting prospect of photonic time crystals. In this perspective, we outline the most recent material advances that are promising candidates for photonic time crystals.

Photonic topological insulator induced by a dislocation in three dimensions.

The hallmark of topological insulators (TIs) is the scatter-free propagation of waves in topologically protected edge channels. This transport is strictly chiral on the outer edge of the medium and therefore capable of bypassing sharp corners and imperfections, even in the presence of substantial disorder. In photonics, two-dimensional (2D) topological edge states have been demonstrated on several different platforms and are emerging as a promising tool for robust lasers, quantum devices and other applications.

Amplified emission and lasing in photonic time crystals.

Photonic time crystals (PTCs), materials with a dielectric permittivity that is modulated periodically in time, offer new concepts in light manipulation. We study theoretically the emission of light from a radiation source placed inside a PTC and find that radiation corresponding to the momentum bandgap is exponentially amplified, whether initiated by a macroscopic source, an atom, or vacuum fluctuations, drawing the amplification energy from the modulation. The radiation linewidth becomes narrower with time, eventually becoming monochromatic in the middle of the bandgap, which enables us to propose the concept of nonresonant tunable PTC laser.

Light emission by free electrons in photonic time-crystals.

Photonic time-crystals (PTCs) are spatially homogeneous media whose electromagnetic susceptibility varies periodically in time, causing temporal reflections and refractions for any wave propagating within the medium. The time-reflected and time-refracted waves interfere, giving rise to Floquet modes with momentum bands separated by momentum gaps (rather than energy bands and energy gaps, as in photonic crystals). Here, we present a study on the emission of radiation by free electrons in PTCs.

Topological insulator vertical-cavity laser array.

Topological insulator lasers are arrays of semiconductor lasers that exploit fundamental features of topology to force all emitters to act as a single coherent laser. In this study, we demonstrate a topological insulator vertical-cavity surface-emitting laser (VCSEL) array. Each VCSEL emits vertically, but the in-plane coupling between emitters in the topological-crystalline platform facilitates coherent emission of the whole array.

Synthetic-Space Photonic Topological Insulators Utilizing Dynamically Invariant Structure.

Synthetic-space topological insulators are topological systems with at least one spatial dimension replaced by a periodic arrangement of modes, in the form of a ladder of energy levels, cavity modes, or some other sequence of modes. Such systems can significantly enrich the physics of topological insulators, in facilitating higher dimensions, nonlocal coupling, and more. Thus far, all synthetic-space topological insulators relied on active modulation to facilitate transport in the synthetic dimensions.

Disordered Photonic Time Crystals.

We study the propagation of electromagnetic waves in disordered photonic time crystals: spatially homogenous media whose refractive index changes randomly in time. We find that the group velocity of a pulse propagating in such media decreases exponentially, eventually coming to a complete stop, while experiencing exponential growth in intensity. These effects greatly depend on the Floquet band structure of the photonic time crystal, with the strongest sensitivity to disorder occurring in superluminal modes.

Correction of murine sickle cell disease by allogeneic haematopoietic cell transplantation with anti-3rd party veto cells.

Despite advances in gene therapy allogeneic hematopoietic stem cell transplants (HSCT) remains the most effective way to cure sickle cell disease (SCD). However, there are substantial challenges including lack of suitable donors, therapy-related toxicity (TRM) and risk of graft-versus-host disease (GvHD). Perhaps the most critical question is when to do a transplant for SCD.

Fostering Self-Management of Everyday Memory in Older Adults: A New Intervention Approach.

Traditional memory strategy training interventions improve older adults' performance on tests of episodic memory, but have limited transfer to episodic memory tasks, let alone to everyday memory. We argue that an alternative approach is needed to assist older adults to compensate for age-related cognitive declines and to maintain functional capacity in their own natural ecologies. We outline a set of principles regarding how interventions can successfully train older adults to increase successful goal pursuit to reduce risks of everyday memory failures.

Initial Evidence for the Efficacy of an Everyday Memory and Metacognitive Intervention.

Background And Objectives: The objective of this paper is to demonstrate the efficacy of an Everyday Memory and Metacognitive Intervention (EMMI) designed to improve everyday functioning of older adults. The EMMI emphasizes self-regulation as a behavioral approach to take priority over habitual behaviors that often impede everyday functioning.

Research Design And Methods: This study used a quasi-experimental design (intervention vs waitlist control) to test whether the EMMI improved several aspects of everyday cognition.

Sex-dependent effects of an Hnrnph1 mutation on fentanyl addiction-relevant behaviors but not antinociception in mice.

Opioid Use Disorder (OUD) and opioid-related deaths remain a major public health concern in the United States. Both environmental and genetic factors influence risk for OUD. We previously identified Hnrnph1 as a quantitative trait gene underlying the stimulant, rewarding, and reinforcing properties of methamphetamine.

Identifying Topological Phase Transitions in Experiments Using Manifold Learning.

We demonstrate the identification of topological phase transitions from experimental data using diffusion maps: a nonlocal unsupervised machine learning method. We analyze experimental data from an optical system undergoing a topological phase transition and demonstrate the ability of this approach to identify topological phase transitions even when the data originates from a small part of the system, and does not even include edge states.

Time-Restricted Feeding and Potential for Type 2 Diabetes Mellitus: A Narrative Review.

Intermittent fasting (IF) is an increasingly popular strategy for weight loss and improved metabolic health. IF regimes involve deliberate implementation of fasting windows ranging from 12 to 72 hours. During these fasting windows, individuals reduce their caloric intake by 75% to 100%.

Photonic Floquet topological insulators in a fractal lattice.

We present Floquet fractal topological insulators: photonic topological insulators in a fractal-dimensional lattice consisting of helical waveguides. The helical modulation induces an artificial gauge field and leads to a trivial-to-topological phase transition. The quasi-energy spectrum shows the existence of topological edge states corresponding to real-space Chern number 1.

Transgenic Analyses of Homer2 Function Within Nucleus Accumbens Subregions in the Regulation of Methamphetamine Reward and Reinforcement in Mice.

Problems associated with the abuse of amphetamine-type stimulants, including methamphetamine (MA), pose serious health and socioeconomic issues world-wide. While it is well-established that MA's psychopharmacological effects involve interactions with monoamine neurotransmission, accumulating evidence from animal models implicates dysregulated glutamate in MA addiction vulnerability and use disorder. Recently, we discovered an association between genetic vulnerability to MA-taking and increased expression of the glutamate receptor scaffolding protein Homer2 within both the shell and core subregions of the nucleus accumbens (NAC) and demonstrated a necessary role for Homer2 within the shell subregion in MA reward and reinforcement in mice.

Photonic topological insulator in synthetic dimensions.

Topological phases enable protected transport along the edges of materials, offering immunity against scattering from disorder and imperfections. These phases have been demonstrated for electronic systems, electromagnetic waves, cold atoms, acoustics and even mechanics, and their potential applications include spintronics, quantum computing and highly efficient lasers. Typically, the model describing topological insulators is a spatial lattice in two or three dimensions.

Behaviors and Strategies Supporting Everyday Memory in Older Adults.

Background: Little is known about the means by which older adults achieve memory-demanding goals in everyday life or alternatively about why they fail to do so.

Objectives: We conducted qualitative interviews to evaluate what older people do to support everyday memory functioning. A principal focus was on understanding the ways in which individuals use internal memory strategies and external memory aids.

Muscarinic receptors participation in angiogenic response induced by macrophages from mammary adenocarcinoma-bearing mice.

Introduction: The role of macrophages in tumor progression has generated contradictory evidence. We had previously demonstrated the ability of peritoneal macrophages from LMM3 murine mammary adenocarcinoma-bearing mice (TMps) to increase the angiogenicity of LMM3 tumor cells, mainly through polyamine synthesis. Here we investigate the ability of the parasympathetic nervous system to modulate angiogenesis induced by TMps through the activation of the muscarinic acetylcholine receptor (mAchR).

Different mechanisms lead to the angiogenic process induced by three adenocarcinoma cell lines.

Neoangiogenesis is essential for tumor and metastasis growth, but this complex process does not follow the same activation pathway, at least in tumor cell lines originated from different murine mammary adenocarcinomas. LMM3 cells were the most potent to stimulate new blood vessel formation. This response was significantly reduced by preincubating cells with indomethacin and NS-398, non-selective cyclooxygenase (COX) and COX-2 selective inhibitors, respectively.

Oxidative stress in Alzheimer's and vascular dementias: masking of the antioxidant profiles by a concomitant Type II diabetes mellitus condition.

Oxidative stress is associated with Alzheimer's (DAT) and vascular (VD) dementias, as well as Type II diabetes mellitus (DIAB) and affected by hypoglycemic therapy. The population (n = 122; males = 60; mean age = 72.57 +/- 7.