[Chemical mucolysis and obliteration of the gallbladder lumen in high surgical risk patients (experimental study)].

A method for obliteration of the gallbladder, based on its mucoclasis with phenol preparations, was developed in experiments on unbred dogs. The safety of using preparations based on phenol for chemical demucosation of the gallbladder is demonstrated. The suggested method may serve as a prototype for the development of similar interventions in clinical practice in acute cholecystitis and cholelithiasis after endoscopic cholecystostomy and cholecystolithoextraction.

[Changes in adenosine deaminase and antioxidative enzyme activity in patients with lung diseases of dust etiology].

Activity of purine metabolism enzyme, adenosine deaminase (ADA) in lymphocytes and erythrocytes from patients with pneumoconiosis and chronic bronchitis was determined. ADA activity decrease was found in lymphocytes and erythrocytes for both decreases. The observed decrease of ADA activity indicates that after the long term work in mineral dust industry damage of purine metabolism takes place, that is similar to the disturbance observed under secondary immunodeficiency.

[Hyperbaric oxygenation in the treatment of compression mononeuropathies].

105 patients with compression mononeuropathies were divided into 2 groups by duration of HBO performed under an original method. The effect of HBO treatment was assessed by changes in neurological symptoms and positive trend on ENMG. The most appreciable response was obtained in acute disease treated by 4-session short course.

[Mechanisms of the therapeutic effect of hyperbaric oxygenation in minor differential pressure in stroke].

Analysis is made of a complex of clinicoelectrophysiologic, biochemical and biophysical studies conducted in 220 patients with brain stroke, receiving a course of hyperbaric oxygenation (HBO) at minor differential pressure (1.2-1.3 absolute atmospheres).

[Antioxidant enzyme activity of the erythrocytes in anemia in children].

Theoretical prerequisites have been submitted for possible alteration in the activity of erythrocytic antioxidant enzymes in children with anemia. The results are presented of the investigation of children with varying anemias for activity of erythrocytic superoxide dismutase and catalase.

[The use of a generalized biochemical parameter for the evaluation of the effectiveness of hemosorption in patients with mechanical jaundice of calculous etiology].

Quantitative methods for evaluation of impairments in the functional state of liver tissue by means of a generalized biochemical index enabled to evaluate efficiency of hemosorption as compared with other methods of preoperative treatment of patients with mechanical jaundice of calculous genesis. Hemosorption was found to contribute most effectively to restoration of the liver tissue functional state decreasing the risk of acute liver tissue insufficiency during the postoperational period.

[Determination of free serum phenol by gas-liquid chromatography in hemosorption].

A modified procedure is developed for estimation of free phenol in blood serum by means of gas-liquid chromatography, appropriate in clinico-biochemical assays. The method enabled to evacuate the blood serum free phenol in healthy persons as well as in various pathologies of abdominal cavity before and after hemosorption. After hemosorption a distinct decrease of the free phenol content was observed in blood, correlating with improved clinico-biochemical patterns of the patients, with a decrease in encephalopathy manifestations as well as with normalization of the neurological status.

[The serum enzymogram for the evaluation of the effectiveness of hemosorption in patients with acute destructive pancreatitis].

To evaluate the hemosorption efficacy in patients with acute destructive pancreatitis, the authors suggest an enzymogram consisting of 4 enzymatic tests: trypsin, trypsin inhibitor, gamma-glutamyltranspeptidase, pseudocholinesterase. It was demonstrated that these enzymes are highly informative, mirroring liver and pancreatic functions. After hemosorption these indicators were discovered to be improved as compared to those in controls.