[The enhanced bioavailability of mebendazole in echinococcosis patients when used with Essentiale].

Mebendasole is better absorbed in the gastrointestinal tract if administered together with essential to patients with hydatid disease. Thirty-four patients with alveolar and hydatid echinococcosis were administered mebendasol in a daily dose of 50 mg/kg in 4 doses and essentiale in a daily dose of 600-1000 mg in 4 doses. A total of 86 therapeutic courses, 30 days each, were carried out.

[Interleukin-1 production in patients with subacute and chronic opisthorchiasis].

Interleukin-1 (IL-1) production by peripheral blood lymphocytes was studied in 3 patients with the subacute and in 28 patients with the chronic stage of the disease. Monocyte culture was obtained by the H. R.

[The computer processing of data from experimental research on malaria. 2. The quantitative characteristics of parasitemia dynamics].

Models of simple and modified logistic function have been used for the quantitative characteristics of malaria infection development. The approach could be successfully used, which was demonstrated on experimental infection dynamics in rodents during parasitemia assessment both in absolute and logarithmic scales. Regression analysis of experimental data and choice of an optimal form of logistic equation are performed with the help of specially elaborated software.

[The computer processing of experimental research data on malaria. 1. The primary processing of the dynamic indices of malarial infection].

Universal computer software for primary statistical and graphic analysis of data on malaria dynamics in patients and in the experiment has been suggested. The analysis of the results of investigations on rodent malaria model in based on graded parasitemia assessment according to Moshkovskiĭ [correction of Mashkovsky].

[A computer estimation of Plasmodium falciparum sensitivity to antimalarial compounds based on in vitro test data].

A modified computer programme has been suggested for the assessment of falciparum malaria agent sensitivity to malariacidal agents. Regression analysis of the results of the in vitro tests is performed using a logistic function.

[Interleukin-1 production in patients with unilocular echinococcosis].

The production of interleukin-1 (IL-1) by peripheral blood monocytes was estimated by the H. R. Recalde method (1984) in 45 patients with echinococcosis and 10 virtually healthy controls.

[Clinical trial of the possibility of increasing the bioavailability of mebendazole using sunflower oil in echinococcosis].

Increasing mebendazole bioavailability is one of the most important problems to be solved in echinococcosis chemotherapy. The method of mebendazole administration with sunflower oil, elaborated by the authors, serves to this purpose: drug concentration exceeding the minimal effective one was attained in 86% patients treated with mebendazole and sunflower oil and only in 40% patients treated with the drug alone.