Diversity of Neurotransmitter-Producing Human Skin Commensals.

Recent findings indicate that human microbiota can excrete trace amines, dopamine, and serotonin. These neurotransmitters (NTs) can either affect classical neurotransmitter signaling or directly trigger trace amine-associated receptors (TAARs), with still unclear consequences for host physiology. Compared to gut microbiota, less information is available on the role of skin microbiota in NT production.

Detection of Vancomycin Resistant Genes in Intrinsically Antibiotic Resistant Bacteria from the Gut Microbiota of Indonesian Individuals.

Background: Antibiotic resistance is a global public health concern that has been exacerbated by the overuse and misuse of antibiotics, leading to the emergence of resistant bacteria. The gut microbiota, often influenced by antibiotic usage, plays a crucial role in overall health. Therefore, this study aimed to investigate the prevalence of antibiotic resistant genes in the gut microbiota of Indonesian coastal and highland populations, as well as to identify vancomycin-resistant bacteria and their resistant genes.

Impact of Probiotic Lactiplantibacillus plantarum ATCC 14917 on atherosclerotic plaque and its mechanism.

Atherosclerosis is viewed as not just as a problem of lipid build-up in blood vessels, but also as a chronic inflammatory disease involving both innate and acquired immunity. In atherosclerosis, the inflammation of the arterial walls is the key characteristic that significantly contributes to both the instability of plaque and the occlusion of arteries by blood clots. These events ultimately lead to stroke and acute coronary syndrome.

Mood and microbes: a comprehensive review of intestinal microbiota's impact on depression.

Depression is considered a multifaceted and intricate mental disorder of growing concern due to its significant impact on global health issues. The human gut microbiota, also known as the "second brain," has an important role in the CNS by regulating it through chemical, immunological, hormonal, and neurological processes. Various studies have found a significant bidirectional link between the brain and the gut, emphasizing the onset of depression therapies.

Role of the intestinal microbiome and its therapeutic intervention in cardiovascular disorder.

The gut microbiome is a heterogeneous population of microbes comprising viruses, bacteria, fungi, and protozoa. Such a microbiome is essential for sustaining host equilibrium, and its impact on human health can be altered by a variety of factors such as external variables, social behavior, age, nutrition, and genetics. Gut microbes' imbalances are related to a variety of chronic diseases including cancer, obesity, and digestive disorders.

Fever-like temperature impacts on Staphylococcus aureus and Pseudomonas aeruginosa interaction, physiology, and virulence both in vitro and in vivo.

Background: Staphylococcus aureus (SA) and Pseudomonas aeruginosa (PA) cause a wide variety of bacterial infections and coinfections, showing a complex interaction that involves the production of different metabolites and metabolic changes. Temperature is a key factor for bacterial survival and virulence and within the host, bacteria could be exposed to an increment in temperature during fever development. We analyzed the previously unexplored effect of fever-like temperatures (39 °C) on S.

Unpacking the relationship between technological conflicts, dissatisfaction, and social media discontinuance intention: An integrated theoretical perspective.

Previous research has largely overlooked the examination of the association between family, work, and personal (FWP) conflict, user dissatisfaction, and subsequent discontinuation intention in the context of social networking sites (SNS). Addressing this research gap, the present study aims to present an integrated theoretical perspective that combines Expectancy Disconfirmation Theory (EDT) and Merton's functions. By doing so, we seek to provide a comprehensive understanding of the factors influencing SNS withdrawal behavior.

A decision-making technique under interval-valued Fermatean fuzzy Hamacher interactive aggregation operators.

The evolution of a novel technique to handle multi-attribute decision-making (MADM) problems under interval-valued Fermatean fuzzy numbers is the main motivation of this paper. We aim to introduce several initiative aggregation operators (AOs), including Hamacher interactive weighted averaging, Hamacher interactive ordered weighted averaging, Hamacher interactive hybrid weighted averaging operations, etc., to acquire our desired outcomes.

From an Hsp90 - binding protein to a peptide drug.

The Lpl proteins represent a class of lipoproteins that was first described in the opportunistic bacterial pathogen , where they contribute to pathogenicity by enhancing F-actin levels of host epithelial cells and thereby increasing internalization. The model Lpl protein, Lpl1 was shown to interact with the human heat shock proteins Hsp90α and Hsp90ß, suggesting that this interaction may trigger all observed activities. Here we synthesized Lpl1-derived peptides of different lengths and identified two overlapping peptides, namely, L13 and L15, which interacted with Hsp90α.

Patch Technique for Primary Treatment of Type A Carotid Cavernous Fistula: A Case Series and Technical Notes.

Background: The utilization of flow diverters (FDs) in the treatment of high-flow Type A carotid cavernous fistulas (CCFs) has been described before mainly as an adjunct to the traditional endovascular techniques and rarely as a stand-alone treatment. In this study, we retrospectively evaluated our experience with FDs as the solo nonadjunctive treatment of Type A CCF with severe cortical venous reflux (CVR).

Methods: A retrospective review was performed of patients with Type A CCFs who were treated using FDs' patch technique (PT).

The orchestra of human bacteriome by hormones.

Human microbiome interact reciprocally with the host. Recent findings showed the capability of microorganisms to response towards host signaling molecules, such as hormones. Studies confirmed the complex response of bacteria in response to hormones exposure.

Fever-like temperature impacts on and interaction, physiology, and virulence both and .

Background: and cause a wide variety of bacterial infections and coinfections, showing a complex interaction that involves the production of different metabolites and metabolic changes. Temperature is a key factor for bacterial survival and virulence and within the host, bacteria could be exposed to an increment in temperature during fever development. We analyzed the previously unexplored effect of fever-like temperatures (39°C) on USA300 and PAO1 microaerobic mono- and co-cultures compared with 37°C, by using RNAseq and physiological assays including experiments.

Identification of a serotonin N-acetyltransferase from ED99.

Serotonin N-acetyltransferase (SNAT) catalyzes the biosynthesis of N-acetylserotonin (NAS) and N-acetyltryptamine (NAT), two pleiotropic molecules with neurotransmitter functions. Here, we report the identification of a SNAT protein in the genus . The SNAT gene identified in ED99, namely , encodes a 140 residues-long cytoplasmic protein.

Multi-attribute decision-making for electronic waste recycling using interval-valued Fermatean fuzzy Hamacher aggregation operators.

The utilization of electrical and electronics equipments in waste recycling has become a paramount for various countries. The waste electrical and electronics equipment (WEEE) recyclers own a crucial position in the environmental growth of a country as they help to minimize the carbon emissions during the recycling of WEEE in the most eco-friendly way. Therefore, the selection and assessment of an appropriate WEEE recycling partner has become a most important part of DM (decision-making) applications.

Perspectives of Hospitalists in an Academic Health System.

Objectives: The primary outcome of this study is to assess the perspectives of Hospitalists on their workload and their perceived effects on patient care. The secondary outcomes are to evaluate the satisfaction of the Hospitalists with their compensation, quality of life, scholarship activity and promotion in their department and the support received to achieve this.

Methodology: We developed a 49-question questionnaire.

The rare presentation of a frontal mucocele complicated by a Pott's puffy tumor and an epidural-cutaneous fistula: illustrative case.

Background: Frontal mucoceles develop due to accumulation of mucoid secretions within the frontal sinuses. They can lead to serious consequences with further expansion and destruction of the surrounding bones or infection that might spread intracranially.

Observations: The authors present a case of a 37-year-old male with a frontal mucocele and the rare presentation of Pott's puffy tumor and an epidural-cutaneous fistula, as well as a literature review of previously reported cases of epidural cutaneous fistula and sinocutaneous fistula, their predisposing factors, and their management.

Explore the mechanism for seafarers to reconnect with work after post-pandemic psychological distress (PAPIST): The moderating role of health-supporting climate.

Covid-19 has disrupted the lives of employees all over the world. After experiencing a prolonged yet ongoing destructive event (i.e.

Linking green supply chain management practices with competitiveness during covid 19: The role of big data analytics.

Although the global green supply chain management (GSCM) practice has attracted considerable scholarly attention, its efficacy for environmental management systems (EMS) and market competitiveness during Covid-19 has not been fully capitalized. Therefore, the existing literature indicates that the important link between GSCM, EMS, and market competitiveness is missing as supply management is crucial to maintaining market competitiveness. To fill this research gap, the current study examines whether EMS affects the relationship between GSCM practices and market competitiveness.

Microbiome profile of soil and rhizosphere plants growing in traditional oil mining land in Wonocolo, Bojonegoro, Indonesia.

Traditional oil mining poses negative effects on the environment through pollution with crude oil. One of the traditional mining sites in Wonocolo, Bojonegoro, Indonesia was reported to contaminate the surrounding area with a high level of crude oil. Therefore, this study aims to examine the microbiome profiles of contaminated soil and the rhizosphere of naturalized plants growing at the sites.

Soil Mineral Composition and Salinity Are the Main Factors Regulating the Bacterial Community Associated with the Roots of Coastal Sand Dune Halophytes.

Soil salinity and mineral deficiency are major problems in agriculture. Many studies have reported that plant-associated microbiota, particularly rhizosphere and root microbiota, play a crucial role in tolerance against salinity and mineral deficiency. Nevertheless, there are still many unknown parts of plant-microbe interaction, especially regarding their role in halophyte adaptation to coastal ecosystems.

Molecular Basis of Rhodomyrtone Resistance in Staphylococcus aureus.

Rhodomyrtone (Rom) is a plant-derived broad-spectrum antibiotic active against many Gram-positive pathogens. A single point mutation in the regulatory gene (*) confers resistance to Rom in Staphylococcus aureus (RomR). The mutation in * alters the activity of the regulator, FarR*, in such a way that not only its own gene, *, but also the divergently transcribed gene and genes controlled by the global regulator, , are highly upregulated.

Degree based models of granular computing under fuzzy indiscernibility relations.

The aim of this research work is to put forward fuzzy models of granular computing based on fuzzy relation and fuzzy indiscernibility relation. Thanks to fuzzy information granulation to provide multi-level visualization of problems that include uncertain information. In such a granulation, fuzzy sets and fuzzy graphs help us to represent relationships among granules, groups or clusters.

The Ambivalent Role of Skin Microbiota and Adrenaline in Wound Healing and the Interplay between Them.

After skin injury, wound healing sets into motion a dynamic process to repair and replace devitalized tissues. The healing process can be divided into four overlapping phases: hemostasis, inflammation, proliferation, and maturation. Skin microbiota has been reported to participate in orchestrating the wound healing both in negative and positive ways.

Application strategies by selective medium treated with entomopathogenic bacteria and as potential biocontrol against .

The success of microbial termiticides in controlling termites depends on the ability of microbes to grow in different media and the functionality of the microbes as a resistant barrier or toxic bait. This study was conducted to understand the mortality rate and behaviour changes of the subterranean termite Holmgren introduced with different concentrations of strain LGMS 1 and strain LGMS 3 using wood and soil as bacterial transfer medium. In general, higher concentration of bacteria in soil caused a reduction in tunnelling activity and wood consumption and an increase in mortality.