Publications by authors named "Lupita S Lopez"
Article Synopsis
- The tumor microenvironment (TME) negatively impacts T cell function and hinders effective immunotherapy for solid tumors, especially those infiltrated with M2 macrophages, which are linked to tumor growth and poor immunotherapy response.
- A novel in vitro co-culture system was developed to study the interactions between tumor cells, CAR T cells, and different macrophage types (M1 and M2) to assess T cell activity and molecular responses.
- Results showed that M2 macrophages inhibit CAR T cell activity by increasing PD-L1 expression, whereas M1 macrophages do not have this negative effect; targeting PD-L1 during CAR T therapy enhances T cell function and anti-tumor effects by converting M2 macrophages to a more favorable
Chimeric antigen receptor (CAR) T cell therapy has led to impressive clinical responses in patients with hematological malignancies; however, its effectiveness in patients with solid tumors has been limited. While CAR T cells for the treatment of advanced prostate and pancreas cancer, including those targeting prostate stem cell antigen (PSCA), are being clinically evaluated and are anticipated to show bioactivity, their safety and the impact of the immunosuppressive tumor microenvironment (TME) have not been faithfully explored preclinically. Using a novel human PSCA knockin (hPSCA-KI) immunocompetent mouse model, we evaluated the safety and therapeutic efficacy of PSCA-CAR T cells.
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