Publications by authors named "Luping Cui"
Previous research suggests mitochondrial apoptosis alleviates rheumatoid arthritis (RA), but the role of mitochondrial apoptosis-related genes (MARGs) is unclear. Urgent exploration of RA-related mitochondrial apoptosis biomarkers is needed. Gene Expression Ontology (GEO)-derived RA datasets were used to identify differentially expressed genes (DEGs) compared to normal controls, intersected with MARGs to obtain differentially expressed mitochondrial apoptosis-related genes (DE-MARGs).
View Article and Find Full Text PDFBackground: Cutaneous melanoma is one of the most invasive and lethal skin malignant tumors. Compared to primary melanoma, metastatic melanoma (MM) presents poorer treatment outcomes and a higher mortality rate. The tumor microenvironment (TME) plays a critical role in MM progression and immunotherapy resistance.
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- - The study investigated infection rates in patients with systemic lupus erythematosus (SLE) undergoing different dosages of intravenous cyclophosphamide (IV-CYC) treatment.
- - Out of 1022 SLE patients, those on a lower-dose, short-interval IV-CYC regimen showed a significantly reduced infection rate compared to those on a higher-dose regimen (13.04% vs 22.27%).
- - Key findings indicated that respiratory and skin infections were less common in the lower-dose group, and infections were more likely in patients with certain risk factors, such as lower white blood cell counts and higher glucocorticoid doses.
Chondrocyte apoptosis contributes to osteoarthritis, while miR-146a is a critical player in chondrocyte apoptosis. Our bioinformatics analysis showed that miR-146a may bind with long non-coding RNA (lncRNA) CALML3 antisense RNA 1 (CALML3-AS1). Our study was therefore carried out to investigate the interactions between lncRNA CALML3-AS1 and miR-146a in osteoarthritis.
View Article and Find Full Text PDFIntroduction: Osteoarthritis (OA) is a common inflammatory joint disease characterised by progressive cartilage destruction. Management of this condition remains a significant challenge, and new therapies are required. We investigated the protective effects of miR-106a mimics in a murine model of OA.
View Article and Find Full Text PDFBackground/aims: Rheumatoid arthritis synovial fibroblasts (RASF) play an essential role in the pathogenesis of rheumatoid arthritis (RA). This study aimed to investigate the biological effects of miR-22 on RASFs.
Methods: RT-qPCR was used to detect the expressions of miR-22 and SIRT1 in RA synovial tissue.