LATS2 degradation promoted fibrosis damage and rescued by vitamin K3 in lupus nephritis.

Background: Lupus nephritis (LN) is the most common complication of systemic lupus erythematosus (SLE). The limited treatment options for LN increase the economic burdens on patients. Because fibrotic progression leads to irreversible renal damage in LN patients and further progresses to chronic kidney disease (CKD) and the end stage of renal disease (ESRD), developing new targets to prevent LN fibrotic progression could lead to a feasible treatment strategy for LN patients.

Study on the proportion of paste filling materials based on fluorogypsum.

A new type of paste filling material was created using fluorogypsum, a byproduct of hydrofluoric acid, as the raw material to address the issue of the filling material's high cost. The effects of five factors, including gangue, fly ash, fluorogypsum, lime content, and mass concentration on the physical and mechanical properties of filling material were also examined. In addition to analyzing slump and extension changes, the filler's mineral composition and microstructure were examined using SEM and XRD examinations.

Mechanical properties and acoustic emission characteristics of deep hard coal after segmented high-temperature treatment.

Based on engineering background that local heating of coal seam is uneven due to underground coal gasification, coal-bed gas exploitation via heat injection, spontaneous combustion of coal seam, etc., segmented heating coal sample was used to simulate coal seam under uneven heating condition, and experimental study on mechanical behaviors of coal sample after segmented heat treatment at high temperatures was conducted. Test results show that temperature at 100 °C ~ 400 °C did not reach ignition temperature of deep hard coal for the experiment and was not enough to change main ingredients of coal sample, which less affected compression strength, elastic modulus, acoustic emission behavior of coal sample.

Study on the dynamic characteristics of rock surrounding a wellbore in energy storage areas during deep geothermal energy mining.

Based on the engineering background in which the rock surrounding a wellbore is affected by a thermal shock, impact disturbances from drilling vibration, cyclic heat extraction and high temperature during hydrothermal geothermal energy mining, the environmental conditions in the shaft wall rock are simulated by means of high temperature, cooling, immersing granite in water with different curing temperatures and applying impact loads. Additionally, an experimental study on the mechanical characteristics of circular granite specimens under radial impact loads and in the heat treatment and water curing conditions is carried out. The results show that the inner diameters of the rings, heating temperatures, curing water temperatures and cycle heating times are less affected than other parameters by the impact load-strain curves of circular granite, which can generally be divided into three sections, i.

Dynamic mechanical characteristics and failure mode of serpentine under a three-dimensional high static load and frequent dynamic disturbance.

The improved split Hopkinson pressure bar (SHPB) was used to study the dynamic mechanical properties and failure characteristics of surrounding rock in deep rock mass engineering that is under high stress and affected by blasting excavation and other dynamic disturbances. In a three-dimensional high static load and frequent dynamic disturbance test, the preload high axial pressure and confining pressure are used to simulate the high crustal stress of deep rock, and the effect of small disturbances on the rock is simulated by the low impact load. The results show that there are two types of dynamic stress-strain curves of deep rock: an elastic-plastic curve and plastic-elastic-plastic curve.

Novel bioconversions of municipal effluent and CO₂ into protein riched Chlorella vulgaris biomass.

Batch, modified semi-continuous and continuous cultivations of Chlorella vulgaris C9-JN 2010 cells in municipal effluent were performed and analyzed. The experiments were carried out in 7.5-L photo-bioreactors, to which 2% of CO2 was supplied.