Pharmacokinetics of single, oral-dose voriconazole in peritoneal dialysis patients.

Background: Voriconazole is a new triazole antifungal drug. Its pharmacokinetics and transfer to peritoneal dialysate in peritoneal dialysis (PD) patients have not been studied.

Methods: Five patients with end-stage renal disease requiring support by PD were administered a single dose of 200 mg of voriconazole orally.