Publications by authors named "Luojie Qiu"
Ovarian cancer is a highly heterogeneous tumor with a poor prognosis. The lack of reliable and efficient research models that can accurately mimic heterogeneity has impeded in-depth investigations and hindered the clinical translation of research findings in ovarian cancer. Organoid models have emerged as a promising in vitro approach, demonstrating remarkable fidelity to the histological, molecular, genomic, and transcriptomic features of their tissues of origin.
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- The study aims to construct a mutation map of homologous recombination repair (HRR) genes in ovarian cancer (OC) and evaluate factors that affect the effectiveness of poly (ADP-ribose) polymerase inhibitors (PARPi).
- Data was collected from 695 OC patients who underwent next-generation sequencing to identify genetic variants and assess the impact of treatment regimens on PARPi efficacy.
- Results revealed a high prevalence of BRCA1 mutations and indicated that first-line maintenance therapy significantly improves progression-free survival in patients treated with PARPi, emphasizing the need for targeted research in HRR gene mutations for better treatment strategies.
Radioresistance is the major obstacle that affects the efficacy of radiotherapy which is an important treatment for cervical cancer. By analyzing the databases, we found that aldolase A (ALDOA), which is a key enzyme in metabolic reprogramming, has a higher expression in cervical cancer patients and is associated with poor prognosis. We detected the expression of ALDOA in the constructed cervical cancer radioresistance (RR) cells by repetitive irradiation and found that it was upregulated compared to the control cells.
View Article and Find Full Text PDFTreatment strategies for intrauterine adhesion: focus on the exosomes and hydrogels.
Front Bioeng Biotechnol
August 2023
Intrauterine adhesion (IUA), also referred to as Asherman Syndrome (AS), results from uterine trauma in both pregnant and nonpregnant women. The IUA damages the endometrial bottom layer, causing partial or complete occlusion of the uterine cavity. This leads to irregular menstruation, infertility, or repeated abortions.
View Article and Find Full Text PDFCharacterization of fecal microbiota in cervical cancer patients associated with tumor stage and prognosis.
Front Cell Infect Microbiol
March 2023
Article Synopsis
- Cervical cancer is the fourth most common cancer among women globally, and research shows that gut microbiota may influence its development and treatment.
- * In a study, researchers analyzed fecal samples from cervical cancer patients and healthy individuals using advanced sequencing methods, revealing significant differences in their gut microbiota composition.
- * The results indicate that specific gut bacteria could serve as potential biomarkers for cervical cancer and that these bacteria are linked to different metabolic activities in the two groups.
Article Synopsis
- - Radiotherapy is a key treatment for cervical cancer, but many patients experience radioresistance, which reduces its effectiveness.
- - The main causes of radioresistance include tumor cells' ability to repair DNA damage and the heightened self-healing of cancer stem cells, making treatment challenging.
- - Recent research highlights the role of the tumor microenvironment, particularly its metabolic processes, in influencing radioresistance, suggesting that understanding these mechanisms may lead to better therapies and improved patient outcomes.
Aldolase A (ALDOA) is an enzyme that plays an important role in glycolysis and gluconeogenesis, which is closely related to tumor metabolism. In this study, the overall roles of ALDOA in pan-cancer have been investigated from several aspects using databases and online analysis tools. Using the ONCOMINE database, the expression of ALDOA in various cancers was analyzed.
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