Safety, pharmacokinetics and pharmacodynamics of SHR-1703, an innovative long-acting anti-interleukin-5 monoclonal antibody, in healthy subjects: a randomized, double-blind, dose-escalation, placebo-controlled phase I study.

Objective: SHR-1703 is a novel humanized IgG1 monoclonal antibody with high IL-5 affinity and prolonged half-life, aiming to control eosinophil-related diseases. The study intended to evaluate pharmacokinetics, pharmacodynamics, immunogenicity, safety, and tolerability of SHR-1703 in healthy subjects.

Methods: A single-center, randomized, double-blind, placebo-controlled, single-dose escalation phase I study was conducted.

Safety, immunogenicity and protective effectiveness of heterologous boost with a recombinant COVID-19 vaccine (Sf9 cells) in adult recipients of inactivated vaccines.

Vaccines have proven effective in protecting populations against COVID-19, including the recombinant COVID-19 vaccine (Sf9 cells), the first approved recombinant protein vaccine in China. In this positive-controlled trial with 85 adult participants (Sf9 cells group: n = 44; CoronaVac group: n = 41), we evaluated the safety, immunogenicity, and protective effectiveness of a heterologous boost with the Sf9 cells vaccine in adults who had been vaccinated with the inactivated vaccine, and found a post-booster adverse events rate of 20.45% in the Sf9 cells group and 31.

Synergistic Effect of Styrene and Carbon Black on the Fatigue Properties of Styrene-Butadiene Rubber Composites.

The increase in the styrene content in styrene-butadiene rubber (SBR) can improve the abrasion performance and cutting resistance of rubber, which has received attention in the tire industry. The fatigue performance is the main evaluation index of rubber materials applied to tires. In this study, the effect of the styrene content and its interaction with carbon black (CB) on the dynamic fatigue performance and mechanism of SBR were investigated.

Comparative Pharmacokinetics and Bioequivalence Evaluation of Two Formulations of Pramipexole Dihydrochloride Extended-Release Tablets in Healthy Chinese Subjects Under Fasted and Fed States: A Randomized, Open-Label, Single-Dose, Two-Period Crossover Clinical Trial.

Background: Pramipexole dihydrochloride extended-release tablet is a novel long-acting form of non-ergot dopamine agonist indicated as one of main therapeutic approaches for Parkinson's disease. However, pharmacokinetic properties of extended-release pramipexole in healthy Chinese subjects remain unclear.

Methods: A single-center, randomized, open-label, two-period crossover, single-dose study was performed to investigate comparative pharmacokinetics and evaluate bioequivalence of 0.

Pharmacokinetics, pharmacodynamics, safety and tolerability of FTP-198, a novel, selective Autotaxin inhibitor, in healthy subjects: A phase I randomized placebo-controlled trial.

Background: Autotaxin (ATX) and lysophosphatidic acid (LPA) play an important role in pathogenesis of idiopathic pulmonary fibrosis (IPF). FTP-198 is an oral, novel and selective ATX inhibitor indicated for treating IPF. The study aimed to investigate the pharmacokinetics, pharmacodynamics, safety and tolerability of FTP-198 in healthy subjects.

Rapid Ozone Decomposition over Water-activated Monolithic MoO /Graphdiyne Nanowalls under High Humidity.

Catalytic ozone (O ) decomposition at high relative humidity (RH) remains a great challenge due to the catalysts poison and deactivation under high humidity. Here, we firstly elaborate the role of water activation and the corresponding mechanism of the promoted O decomposition over the three-dimensional monolithic molybdenum oxide/graphdiyne (MoO /GDY) catalyst. The O decomposition over MoO /GDY reaches up to 100 % under high humid condition (75 % RH) at room temperature, which is 4.

The clinical effects of inclisiran, a first-in-class LDL-C lowering siRNA therapy, on the LDL-C levels in Chinese patients with hypercholesterolemia.

Background: Inclisiran is a novel siRNA therapy that inhibits the synthesis of proprotein convertase subtilisin-kexin type 9 (PCSK9) by targeting the PCSK9 mRNA, consequently, decreases low-density lipoprotein cholesterol (LDL-C).

Objective: To assess the safety, PK and LDL-C lowering effects of inclisiran in the Chinese patients with elevated LDL-C despite treatment with maximally tolerated LDL-C lowering therapies.

Methods: Forty Chinese patients with hypercholesterolemia (LDL-C ≥100 mg/dL) who were on maximally tolerated statin were randomized to receive a single dose of either inclisiran sodium 100 or 300mg s.

Comparative Pharmacokinetics and Safety of Imrecoxib, a Novel Selective Cyclooxygenase-2 Inhibitor, in Elderly Healthy Subjects.

Background: Imrecoxib is a novel and moderately selective cyclooxygenase-2 inhibitor with properties of anti-inflammation and alleviating pain, which is widely applied in osteoarthritis patients. The pharmacokinetic data supporting imrecoxib's rational use in elderly population are not available.

Purpose: The study aims to investigate the pharmacokinetics of imrecoxib and its main metabolites and explore the safety of imrecoxib in elderly healthy subjects.

Dual Activation of Molecular Oxygen and Surface Lattice Oxygen in Single Atom Cu /TiO Catalyst for CO Oxidation.

The in-depth mechanism on the simultaneous activation of O and surface lattice O on one active metallic site has not been elucidated yet. Herein, we report a strategy for the construction of abundant oxygen activation sites by rational design of Cu /TiO single atom catalysts (SACs). The charge transfer between isolated Cu and TiO support generates abundant Cu and 2-coordinated O sites in Cu -O-Ti hybridization structure, which facilitates the chemisorption and activation of O molecules.

Neighboring sp-Hybridized Carbon Participated Molecular Oxygen Activation on the Interface of Sub-nanocluster CuO/Graphdiyne.

Activation of O is a crucial step in oxidation processes. Here, the concept of sp-hybridized C≡C triple bonds as an electron donor is adopted to develop highly active and stable catalysts for molecular oxygen activation. We demonstrate that the neighboring sp-hybridized C and Cu sites on the interface of the sub-nanocluster CuO/graphdiyne are the key structures to effectively modulate the O activation process in the bridging adsorption mode.

Oxygen Vacancy-Governed Opposite Catalytic Performance for CH and CH Combustion: The Effect of the Pt Electronic Structure and Chemisorbed Oxygen Species.

Revealing the role of engineered surface oxygen vacancies in the catalytic degradation of volatile organic compounds (VOCs) is of importance for the development of highly efficient catalysts. However, because of various structures of VOC molecules, the role of surface oxygen vacancies in different catalytic reactions remains ambiguous. Herein, a defective Pt/TiO catalyst is proposed to uncover the different catalytic mechanisms of CH and CH combustion via experiments and theoretical calculations.

Interfacial sp C-O-Mo Hybridization Originated High-Current Density Hydrogen Evolution.

High-current density (≥1 A cm) is a critical factor for large-scale industrial application of water-splitting electrocatalysts, especially seawater-splitting. However, it still remains a great challenge to reach high-current density due to the lack of active and stable intrinsic catalytic active sites in catalysts. Herein, we report an original three-dimensional self-supporting graphdiyne/molybdenum oxide (GDY/MoO) material for efficient hydrogen evolution reaction via a rational design of "sp C-O-Mo hybridization" on the interface.

Engineering the Nucleophilic Active Oxygen Species in CuTiO for Efficient Low-Temperature Propene Combustion.

Industrialization has resulted in the rapid increase of volatile organic compound (VOC) emissions, which have caused serious issues to human health and the environment. In this study, an extensive Cu incorporating TiO induced nucleophilic oxygen structure was constructed in the CuTiO catalyst, which exhibited superior low-temperature catalytic activity for CH combustion. Thorough structural, surface characterization and density functional theory (DFT) calculations revealed that the Cu-O-Ti hybridization induced nucleophilic oxygen initiates CH combustion by abstracting the C-H bond.

Elucidating the Nature of the Cu(I) Active Site in CuO/TiO for Excellent Low-Temperature CO Oxidation.

Stabilized Cu species have been widely considered as catalytic active sites in composite copper catalysts for catalytic reactions with industrial importance. However, few examples comprehensively explicated the origin of stabilized Cu in a low-cost and widely investigated CuO/TiO system. In this study, mass producible CuO/TiO catalysts with interface-stabilized Cu were prepared, which showed excellent low-temperature CO oxidation activity.

Nanostructured MoO for Efficient Energy and Environmental Catalysis.

This paper mainly focuses on the application of nanostructured MoO materials in both energy and environmental catalysis fields. MoO has wide tunability in bandgap, a unique semiconducting structure, and multiple valence states. Due to the natural advantage, it can be used as a high-activity metal oxide catalyst, can serve as an excellent support material, and provide opportunities to replace noble metal catalysts, thus having broad application prospects in catalysis.

Study on Surface Properties of Aramid Fiber Modified in Supercritical Carbon Dioxide by Glycidyl-POSS.

The outstanding diffusivity and permeability of supercritical carbon dioxide (scCO) are extremely beneficial for grafting reaction. In this work, aramid fibers (AF) are modified in scCO by glycidyl-polyhedral oliomeric silsesquioxane (POSS) with 2-ethyl-4-methylimidazole (2E4MZ) on the basis of cleaning with acetone. The surface morphology and chemical structure of the modified AF were measured and characterized by Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), Scanning electron microscope (SEM), Thermogravimetric (TG), and Atomic force microscope (AFM).

Star Shaped Long Chain Branched Poly (lactic acid) Prepared by Melt Transesterification with Trimethylolpropane Triacrylate and Nano-ZnO.

Long chain branched poly (lactic acid) (LCBPLA) was prepared via transesterification between high molecular weight poly (lactic acid) (PLA) and low molar mass monomer trimethylolpropane triacrylate (TMPTA) during melt blending in the presence of zinc oxide nanoparticles (nano-ZnO) as a transesterification accelerant in a torque rheometer. Compared with the traditional processing methods, this novel way is high-efficiency, environmentally friendly, and gel-free. The results revealed that chain restructuring reactions occurred and TMPTA was grafted onto the PLA backbone.

Preparation and properties of long chain branched high-density polyethylene based on nano-SiO grafted glycidyl methacrylate.

A compounded nanoparticle with multiple double bonds (C[double bond, length as m-dash]C) was prepared by grafting glycidyl methacrylate (GMA) onto the surface of nano-SiO. Then gel-free long chain branched polyethylene (LCBPE) was prepared by melt branching reaction in a Haake torque rheometer in the presence of initiator peroxide and GMA grafted nano-SiO (SiO--GMA). The sampling time corresponded to the summit of the reaction peak in the torque curve.

Molecular O Activation over Cu(I)-Mediated C≡N Bond for Low-Temperature CO Oxidation.

The activation of molecular oxygen (O) is extremely crucial in heterogeneous oxidations for various industrial applications. Here, a charge-transfer complex CuTCNQ nanowire (CuTCNQ NW) array grown on the copper foam was first reported to show CO catalytic oxidation activity at a temperature below 200 °C with the activated O as an oxidant. The molecular O was energetically activated over the Cu(I)-mediated C≡N bond with a lower energy of -1.

Molecular Cloning, Expression Analysis, and Functional Characterization of the H(+)-Pyrophosphatase from Jatropha curcas.

H(+)-pyrophosphatase (H(+)-PPase) is a primary pyrophosphate (PPi)-energized proton pump to generate electrochemical H(+) gradient for ATP production and substance translocations across membranes. It plays an important role in stress adaptation that was intensively substantiated by numerous transgenic plants overexpressing H(+)-PPases yet devoid of any correlated studies pointing to the elite energy plant, Jatropha curcas. Herein, we cloned the full length of J.

An acidified thermostabilizing mini-peptide derived from the carboxyl extension of the larger isoform of the plant Rubisco activase.

Thermostable fusion peptide partners are valuable in engineering thermostability in proteins. We evaluated the Arabidopsis counterpart (AtRAce) and an acidified derivative (mRAce) of the conserved carboxyl extension (RAce) of plant Rubisco activase (RCA) for their thermostabilizing properties in Escherichia coli and Saccharomyces cerevisiae using a protein fusion strategy. We used AtRAce and mRAce as fusion tails for the thermolabile protein RCA2 from Arabidopsis thaliana and Nicotiana tabacum.

[Efficacy and Safety of Tiotropium Bromide in the Treatment of Chronic Obstructive Pulmonary Disease--a Multi-center Randomized Clinical Trial].

Objective: To investigate the efficacy and safety of domestic tiotropium inhalation capsule in patients with chronic obstructive pulmonary disease (COPD) with multi-center randomized clinical trial.

Methods: Patients with stable slight to moderate COPD were randomized into trial group (n=109) with tiotropium 18 pg Qd or control group (n =111) with ipratropium 40 µg Qid for a treatment of four weeks. The spirometry and scoring questionaire were recorded at different visits during the treatment.