Probiotics Clostridium butyricum and Bacillus subtilis ameliorate intestinal tumorigenesis.

Aims: To investigate the antitumor effects of probiotics Clostridium butyricum and Bacillus subtilis on colorectal cancer (CRC) progression.

Materials & Methods: The effects of C. butyricum and B.

High suppressor of cytokine signaling-3 expression impairs STAT3-dependent protective effects of interleukin-22 in ulcerative colitis in remission.

Background: High SOCS3 expression in intestinal epithelial cells (IECs) of patients with ulcerative colitis (UC) in remission reflects the shorter time to relapse. We investigated whether high SOCS3 increased risk for relapse through violating STAT3-dependent protective effects of interleukin (IL)-22 during UC remission.

Methods: Expression of IL-22 and c-Myc in UC remission mucosa was analyzed by immunohistochemistry.