Association between sensitivity to thyroid hormone indices and type 2 diabetic microvascular complications in euthyroid patients.

The correlation between thyroid hormone (TH) sensitivity and microvascular complications of type 2 diabetes mellitus (T2DM) remains uncertain. This study aimed to explore the association between TH sensitivity and the risk of diabetic kidney disease (DKD), diabetic retinopathy (DR), and diabetic neuropathy (DNP) in euthyroid T2DM patients. This study included a total of 946 hospitalized T2DM patients and calculated their sensitivity to the TH index, and each patient completed screenings for DKD, DR, and DNP.

Risk classification for non-cancer death in middle-aged cancer patients.

Introduction: Non-cancer events are important causes of competing mortality among cancer patients. However, the risk of non-cancer death and risk classification in middle-aged cancer patients is not clear. To comprehensively analyze the risk of non-cancer deaths in 24 different cancers among middle-aged patients.

Diversity of Lignicolous Freshwater Fungi from Yuanjiang River in Yunnan (China), with the Description of Four New Species.

Yuanjiang River (Red River) is one of the six major water systems in Yunnan Province, which originates from western Yunnan Province. This river system features numerous tributaries, complex terrain, and abundant natural resources. During the investigation on the diversity of lignicolous freshwater fungi in the Yuanjiang River, nine species were collected and identified, five belonging to and four to .

A Review of Current Developments in Functionalized Mesoporous Silica Nanoparticles: From Synthesis to Biosensing Applications.

Functionalized mesoporous silica nanoparticles (MSNs) have been widely investigated in the fields of nanotechnology and material science, owing to their high surface area, diverse structure, controllable cavity, high biocompatibility, and ease of surface modification. In the past few years, great efforts have been devoted to preparing functionalized MSNs for biosensing applications with satisfactory performance. The functional structure and composition in the synthesis of MSNs play important roles in high biosensing performance.

Methane emissions from the riverine sandy wetlands on the Mongolia Plateau.

Methane (CH) processes and fluxes have been widely investigated in low-latitude tropical wetlands and high-latitude boreal peatlands. In the mid-latitude Mongolia Plateau, however, CH processes and fluxes have been less studied, particularly in riverine wetlands. In this study, in situ experiments were conducted in the riverine sandy wetlands of the Mongolia Plateau to gain a better understanding of CH emissions and their influencing mechanisms.

Effects of Peer Video Feedback Based on Cultural Historical Activity Theory in the Operational Training of New Nurses: A Quasi-Experimental Study.

Background: Previous studies have confirmed the potential effectiveness of peer video feedback in the operational training of health care students. However, an appropriate theoretical framework to support peer video feedback has not been established. The cultural historical activity theory (CHAT) provides a suitable framework.

Magnetic Domain Wall Energy Landscape Engineering in a Ferrimagnet.

Architectures based on a magnetic domain wall (DW) can store and process information at a high speed in a nonvolatile manner with ultra-low power consumption. Recently, transition-metal rare earth metal alloy-based ferrimagnets have attracted a considerable amount of attention for the ultrafast current-driven DW motion. However, the high-speed DW motion is subject to film inhomogeneity and device edge defects, causing challenges in controlling the DW motion and hindering practical application.

Preparation of chitin-derived hierarchical porous materials and their application and mechanism in adsorption of mycotoxins.

In this study, the hierarchical porous materials for adsorbing mycotoxins were prepared by one-step carbonization-activation method using potassium permanganate (KMnO) and chitin as activators and carbon source, respectively. The hierarchical porous materials had different specific surface area and pore distribution owing to different carbonization temperatures. In this paper, the effects of pH, time and temperature of adsorption as well as the concentration of patulin on the adsorption characteristics were systematically investigated.

The JNK Signaling Pathway Regulates Seizures Through ENT1 in Pilocarpine-Induced Epilepsy Rat Model.

Objective: The study investigates whether the expression and function of ENT1 can be regulated by inhibiting the JNK signaling pathway, thereby altering the levels of extracellular adenosine and glutamate in neurons, and subsequently affecting the progression of epilepsy.

Methods: The adult male SD rats were randomly divided into four groups: EP + SP600125 group, EP + DMSO group, EP group, and normal control group. The expression levels of ENT1, p-JNK, and JNK in the hippocampus of rats from each experimental group were detected using Western blotting technology.

Gallstones, cholecystectomy, and cancer risk: an observational and Mendelian randomization study.

This study aimed to comprehensively examine the association of gallstones, cholecystectomy, and cancer risk. Multivariable logistic regressions were performed to estimate the observational associations of gallstones and cholecystectomy with cancer risk, using data from a nationwide cohort involving 239 799 participants. General and gender-specific two-sample Mendelian randomization (MR) analysis was further conducted to assess the causalities of the observed associations.

OTULIN confers cisplatin resistance in osteosarcoma by mediating GPX4 protein homeostasis to evade the mitochondrial apoptotic pathway.

Background: Osteosarcoma (OS), the most prevalent primary malignant bone tumor in children and adolescents, arises from bone-forming mesenchymal cells. Despite advancements in surgical resection and neoadjuvant chemotherapy (cisplatin, doxorubicin, and methotrexate), chemotherapy resistance remains a significant challenge, leading to poor survival rates in patients with metastatic or recurrent OS.

Methods: In this study, we focused on the role of OTULIN, a key linear deubiquitinating enzyme, in OS chemoresistance.

Analysis of longitudinal patterns of child maltreatment reports in the United States.

Background: Child maltreatment is a continuous and prevalent issue, and victims of maltreatment often suffer adverse effects well into adulthood. Since child maltreatment rates tend to be clustered geographically and temporally, intervention programs are best implemented at a local level, targeting local risk factors for sustained and effective reduction over time.

Objective: Quantifying geographic variation in child maltreatment rate trajectories can help states identify local risk factors to guide program development and resource allocation.

Study on the effect of occupational exposure on hypertension of steelworkers based on Lasso-Logistic regression model.

Objectives: This study aimed to use a stable and predictive method: Lasso regression model to analyze hypertension's influencing factors and explore the interactions between occupational exposures.

Study Design: This has been a nested case-control study.

Methods: The case group consisted of 959 patients with high blood pressure found during the study.

Immune and physiological responses in to ammonia-N stress: a multi-omics approach.

Ammonia-N stress is a significant environmental factor that adversely affects the health and productivity of aquaculture species. This study investigates the effects of ammonia-N stress on the shrimp through a combination of biochemical, histological, transcriptomic, and metabolomic analyses. Shrimp were exposed to ammonia-N stress for 12 and 96 hours, and key markers of oxidative stress, nitrogen metabolism, immune response, and overall health were assessed.

Artificial intelligence-enabled discovery of a RIPK3 inhibitor with neuroprotective effects in an acute glaucoma mouse model.

Background: Retinal ganglion cell (RGC) death caused by acute ocular hypertension is an important characteristic of acute glaucoma. Receptor-interacting protein kinase 3 (RIPK3) that mediates necroptosis is a potential therapeutic target for RGC death. However, the current understanding of the targeting agents and mechanisms of RIPK3 in the treatment of glaucoma remains limited.

Autophagy-mediated energy charge sustainability alleviated postharvest quality deterioration of strawberry (Fragaria × ananassa).

Fluctuations in energy status are critical physiological factors influencing postharvest fruit quality. However, the role of autophagy, a stress-resistant biological process, in regulating postharvest fruit energy status remains unclear. In this study, we treated strawberry fruit with the autophagy inhibitor hydroxychloroquine (HCQ) to investigate the role of autophagy in maintaining energy status.

Metoprolol adverse events and literature analyses: case/non-case analyses using the FDA Adverse Event Reporting System (FAERS).

Background: In recent years, β-blockers such as metoprolol have been upgraded to first-line antihypertensive drugs. However, metoprolol demonstrates poor prognosis effects on diseases such as stroke. Further clinical application may expand the possibility of its related adverse reactions.

Current Knowledge on Craniodental Anatomy and Dental Pathology in Golden Snub-Nosed Monkeys (Rhinopithecus roxellana): A Comparative Review.

The Sichuan golden snub-nosed monkey (Rhinopithecus roxellana) is a rare and endangered species endemic to China that occupies a particularly important position in the evolutionary history of Rhinopithecus species. Oral health is a crucial aspect of overall well-being in both humans and nonhuman primates. We review the current limited literature on the dental characteristics and dental pathologies related to the golden snub-nosed monkey, based on skeleton data and morphological evidence.

Genetic analysis of partial duplication of the long arm of chromosome 16.

Background: Pure partial trisomy 16q12.1q22.1 is a rare chromosome copy number variant (CNV).

Machine learning-based identification of histone deacetylase-associated prognostic factors and prognostic modeling for low-grade glioma.

Background: Low-grade glioma (LGG) is a slow-growing but invasive tumor that affects brain function. Histone deacetylases (HDACs) play a critical role in gene regulation and tumor progression. This study aims to develop a prognostic model based on HDAC-related genes to aid in risk stratification and predict therapeutic responses.

Manipulating p-π Resonance through Methoxy Group Engineering in Covalent Organic Frameworks for an Efficient Photocatalytic Hydrogen Evolution.

Kinetic factors frequently emerge as the primary constraints in photocatalysis, exerting a critical influence on the efficacy of polymeric photocatalysts. The diverse conjugation systems within covalent organic frameworks (COFs) can significantly impact photon absorption, energy level structures, charge separation and migration kinetics. Consequently, these limitations often manifest as unsatisfactory kinetic behavior, which adversely affects the photocatalytic activity of COFs.

STGAT-CS: spatio-temporal-graph attention network based channel selection for MI-based BCI.

Brain-computer interface (BCI) based on the motor imagery paradigm typically utilizes multi-channel electroencephalogram (EEG) to ensure accurate capture of physiological phenomena. However, excessive channels often contain redundant information and noise, which can significantly degrade BCI performance. Although there have been numerous studies on EEG channel selection, most of them require manual feature extraction, and the extracted features are difficult to fully represent the effective information of EEG signals.

Two secretory T2 RNases from a fungal pathogen target distinct insect cell transmembrane proteins to cause cytotoxicity.

Fungal pathogens produce secretory ribonuclease (RNase) T2 proteins during infection, which contribute to fungal virulence via their enzyme functions in degradation of host cell RNA. However, the details of those proteins entering the host cells are unclear. Our previous study demonstrated that the two secretory RNase T2 members, BbRNT2 and BbTrv, produced by the insect fungal pathogen Beauveria bassiana, caused cytotoxic damage to insect cells and contributed to fungal virulence.