Primary gingival diffuse large B‑cell lymphoma with muscle invasion: A case report.

Primary gingival diffuse large B-cell lymphoma (DLBCL) with muscle invasion is rare and accounts for ~0.5% of all reported cases of extranodal lymphoma. The present study describes the case of a 49-year-old man that initially presented at Yingshan County People's Hospital (Nanchong, China) in August 2017 with a chief complaint of tenderness and swelling of the jaw.

Cerebral endothelial 3-mercaptopyruvate sulfurtransferase improves ischemia-induced cognitive impairment interacting with protein phosphatase 2A.

The catalytic activity of 3-mercaptopyruvate (3MP) sulfurtransferase (MPST) converts 3MP to hydrogen sulfide (HS). However, the regulatory mechanisms governing MPST and its impact on the brain remain largely unexplored. Our study reveals the neuroprotective role of endothelial MPST-generated HS, regulated by protein phosphatase 2A (PP2A).

Ultra-sparse-view Cone-beam CT Reconstruction Based Strictly-structure-preserved Deep Neural Network in Image-guided Radiation Therapy.

Radiation therapy is regarded as the mainstay treatment for cancer in clinic. Kilovoltage cone-beam CT (CBCT) images have been acquired for most treatment sites as the clinical routine for image-guided radiation therapy (IGRT). However, repeated CBCT scanning brings extra irradiation dose to the patients and decreases clinical efficiency.

Post-pericardiectomy ECMO for constrictive pericarditis: a case series and literature review.

Background: Pericardiectomy is the curative treatment for constrictive pericarditis, yet postoperative low cardiac output syndrome (LCOS) may occur. The application of venoarterial extracorporeal membrane oxygenation (VA-ECMO) in post-pericardiectomy refractory LCOS has limited case reports, and its effectiveness and safety remain unclear. This study aims to provide evidence for the effectiveness of ECMO in treating post-pericardiectomy refractory LCOS.

Hyperkalemia is associated with short- and mid-term mortalities in critically ill patients in the MIMIC IV database.

We aimed to explore the association of hyperkalemia and short- and mid-term mortality in critically ill patients using the Medical Information Mart for Intensive Care (MIMIC-IV) database. Adult patients who had been stayed in the intensive care unit (ICU) for at least 48 h and tested for serum potassium were included. Hyperkalemia was defined as serum potassium higher than 5.

Natural bioactive compounds form herbal medicine in Alzheimer's disease: from the perspective of GSK-3β.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory loss. Glycogen synthase kinase 3β (GSK-3β) plays a pivotal role in AD pathogenesis, particularly in tau protein hyperphosphorylation. Natural bioactive compounds have a wide range of sources, and medicinally valuable active compound can be extracted from plants, animals, and microorganisms.

Developing a nomogram prediction model to enhance diagnostic accuracy of supplemental ultrasound post-negative mammography.

The effectiveness of mammography in women with dense breasts is compromised by a high rate of false-negative results. While supplemental ultrasound increases sensitivity, its low positive predictive value (PPV) leads to more unnecessary biopsies. This study aims to develop a nomogram model to predict the malignancy of breast masses that are additionally identified as suspicious by supplemental ultrasound after an initial negative screening mammography.

Age-related p53 SUMOylation accelerates senescence and tau pathology in Alzheimer's disease.

Aging is a major risk factor for Alzheimer's disease (AD). With the prevalence of AD increased, a mechanistic linkage between aging and the pathogenesis of AD needs to be further addressed. Here, we report that a small ubiquitin-related modifier (SUMO) modification of p53 is implicated in the process which remarkably increased in AD patient's brain.

Tailoring molecular diffusion in core-shell zeolite imidazolate framework composites realizes efficient kinetic separation of xylene isomers.

The separation of xylene isomers is a critical and energy-intensive process in the petrochemical industry, primarily due to their closely similar molecular structures and boiling points. In this work, we report the synthesis and application of a novel core-shell zeolitic imidazolate framework (ZIF) composite, ZIF-65@ZIF-67, designed to significantly enhance the kinetic separation of xylene isomers through a synergistic "shell-gated diffusion and core-facilitated transport" strategy. The external ZIF-67 shell selectively restricts the diffusion of larger isomers (MX and OX), while the internal ZIF-65 core accelerates the diffusion of PX, thereby amplifying the diffusion differences among the isomers.

Fluorescent Particles Based on Aggregation-Induced Emission for Optical Diagnostics of the Central Nervous System.

In 2001, Tang's team discovered a unique type of luminogens with substantial enhanced fluorescence upon aggregation and introduced the concept of "aggregation-induced emission (AIE)". Unlike conventional fluorescent materials, AIE luminogens (AIEgens) emit weak or no fluorescence in solution but become highly fluorescent in aggregated or solid states, due to a mechanism known as restriction of intramolecular motions (RIM). Initially considered a purely inorganic chemical phenomenon, AIE was later applied in biomedicine to improve the sensitivity of immunoassays.

Icaritin alleviates motor impairment and osteoporosis in Parkinson's disease mice via the ER-PI3K/Akt pathway.

This study investigates the role of flavonoid Icaritin (ICT) in estrogen-deficient ovariectomized (OVX) female mice by activating the Estrogen receptor (ER)/ Phosphatidylinositol 3-kinase (PI3K)/Protein kinase B (Akt) signaling pathway, potentially delaying Parkinson's disease (PD) progression post-castration. Seventy-five 8-week-old C57BL/6J female mice underwent ovariectomy, followed by MPTP (20 mg/kg) injection for 7 days. ICT (20 mg/kg) was administered for 14 days, and motor function was assessed using various behavioral tests.

Exploring microfluidics-based organoid interactions through analysis of albumin secretion.

Organoids-on-a-chip exhibit significant potential for advancing disease modeling, drug screening, and precision medicine, largely due to their capacity to facilitate interactions among organoids. However, the influence of chip design on these interactions remains poorly understood, primarily due to our limited knowledge of the mediators of communication and the complexity of interaction dynamics. This study demonstrates that analyzing albumin secretion from liver organoids within an organoids-on-a-chip system can provide a measure of the interaction intensity among organoids, offering valuable insights into how chip design influences these interactions.

An intraoperative nomogram for predicting secondary margin positivity in breast conserving surgery utilizing frozen section analysis.

Background: Breast conserving surgery (BCS) is a standard treatment for breast cancer. Intraoperative frozen section analysis (FSA) is widely used for margin assessment in BCS. In addition, FSA-assisted excisional biopsy is still commonly practiced in many developing countries.

Correction: Genetically engineered gas vesicle proteins with proliferative potential for synergistic targeted tumor therapy.

[This corrects the article DOI: 10.1039/D4RA07532C.].

Enhancing biosensing of trace tau protein in clinical samples via emergence macroscopic directed aggregation.

Alzheimer's disease (AD) is an irreversible neurodegenerative disorder that poses a significant risk to human health and well-being. The high cost and invasiveness of neuroimaging and cerebrospinal fluid (CSF) analysis underscores the necessity for accessible early screening via blood samples. In this study, we developed an ultrasound-based strategy for emergent macroscopic that enhances the acoustic response enrichment of specific proteins by introducing functionalized microspheres.

Engineering Defect-Mediated S-scheme heterojunctions in MOF-Derived N-doped NiO porous microrods and ZnInS nanosheets for superior photocatalytic hydrogen evolution.

The development of efficient photocatalysts inspired by natural photosynthesis has drawn considerable interest for sustainable hydrogen (H) production. Among the various strategies for enhancing H evolution, constructing step-scheme (S-scheme) heterojunctions has attracted extensive interest, thanks to their limited charge recombination and enhanced charge transport in comparison to the traditional photocatalytic systems. Herein, we report the engineering of a novel S-scheme heterojunction by integrating ultrathin ZnInS (ZIS) nanosheets with MOF-derived N-doped NiO porous microrods (ZIS/N-NiO) toward superior photocatalytic behaviors.

Integrated intraoperative predictive model for malignancy risk assessment of thyroid nodules with atypia of undetermined significance cytology.

Management of thyroid nodules with atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) cytology is challenging because of uncertain malignancy risk. Intraoperative frozen section pathology provides real-time diagnosis for AUS/FLUS nodules undergoing surgery, but its accuracy is limited. This study aimed to develop an integrated predictive model combining clinical, ultrasound and IOFS features to improve intraoperative malignancy risk assessment.

Adjuvant effect of green tea intake on treatment of patients with acute venous thromboembolism.

Background: Although there have been reports that green tea intake has thromboprophylactic effect, it was still unknown whether it had adjuvant effect on the basis of conventional anticoagulation for patients diagnosed with venous thromboembolism (VTE).

Methods: VTE patients were retrospectively classified into green tea group and no green tea group in a 1:1 ratio using propensity score matching, based on whether they drank green tea during the 3 months' period after VTE diagnosis. Primary outcomes were VTE recurrence at 3 months after VTE diagnosis and VTE-related death during 3 months after VTE diagnosis.

Genetically engineered gas vesicle proteins with proliferative potential for synergistic targeted tumor therapy.

Nanomedicine enables precision-targeted therapies through a non-invasive approach, and nanoparticles may be biologically affected during their colonization . Ensuring the efficient expression of their performance , while ensuring biosafety, is of great significance. Previous studies have employed genetically engineered following entry as a genetically engineered targeting synergist, to enhance the effect of focused ultrasound ablation by exploiting its targeted colonization of tumor tissue.

Ultrasound-responsive nanoparticles for nitric oxide release to inhibit the growth of breast cancer.

Gas therapy represents a promising strategy for cancer treatment, with nitric oxide (NO) therapy showing particular potential in tumor therapy. However, ensuring sufficient production of NO remains a significant challenge. Leveraging ultrasound-responsive nanoparticles to promote the release of NO is an emerging way to solve this challenge.

ST-GMLP: A concise spatial-temporal framework based on gated multi-layer perceptron for traffic flow forecasting.

The field of traffic forecasting has been the subject of considerable attention as a critical component in alleviating traffic congestion and improving urban services. Given the regular patterns of human activities, it is evident that traffic flow is inherently periodic. However, most of existing studies restrict themselves to recent historical observations and typically yield structurally and computationally complex models, which greatly limits the forecasting accuracy and hinders the application of models in realistic situations.

LncRNA HCP5 acts as a potential diagnostic biomarker and attenuates the inflammatory response in neonatal sepsis by targeting miR-138-5p/SIRT1.

Introduction: This study aimed to investigate the clinical significance and potential mechanism of long non-coding RNA human histocompatibility leukocyte antigen complex P5 (HCP5) in neonatal sepsis (NS).

Material And Methods: The study enrolled 86 patients with NS and 80 neonates with respiratory tract infection or pneumonia. The Pearson correlation coefficient was used to evaluate the association of procalcitonin (PCT), C-reactive protein (CRP), and inflammatory factors with HCP5.

Comprehensive review on Alzheimer's disease: From the posttranslational modifications of Tau to corresponding treatments.

Alzheimer's disease (AD) is a neurodegenerative disease, which is mainly characterized by the abnormal deposition of β-amyloid peptide (Aβ) and Tau. Since Tau aggregation is more closely associated with synaptic loss, neurodegeneration, and cognitive decline than Aβ, the correlation between Tau and cognitive function in AD has gradually gained attention. The posttranslational modifications (PTMs) of Tau are key factors contributing to its pathological changes, which include phosphorylation, acetylation, ubiquitination, glycosylation, glycation, small ubiquitin-like modifier mediated modification (SUMOylation), methylation, succinylation, etc.