Publications by authors named "Luo Ya"
The phenylacetone pathway, which encompasses flavonoids, lignin, and other compounds, is of paramount importance in determining the quality of pear fruit. Nevertheless, the precise regulatory functions of R2R3-MYB transcription factors in the metabolic pathways that regulate pear color changes remain unclear. In this study, we isolated an transcription factor from 'Red Zaosu' pears and demonstrated that it influenced the expression of several genes, including , and .
View Article and Find Full Text PDFWe investigated the protective effect of the NF-κB inhibitor, pyrrolidine dithiocarbamate (PDTC) on cardiomyocyte injury induced by HCN1 channel overexpression, and explored the underlying mechanisms. An HCN1 overexpression vector was constructed and transfected into H9C2 cells, followed by PDTC treatment. The experiments comprised the following groups: control, control + PDTC, overexpression negative control, HCN1 overexpression (HCN1-OE), and combined HCN1-OE + PDTC groups.
View Article and Find Full Text PDFBackground: With the increasing risk of nuclear exposure, more attention has been paid to the prevention and treatment of acute radiation syndrome (ARS). Although amino acids are key nutrients involved in hematopoietic regulation, the impacts of amino acids on bone marrow hematopoiesis following irradiation and the associated mechanisms have not been fully elucidated. Hence, it is of paramount importance to study the changes in amino acid metabolism after irradiation and their effects on hematopoiesis as well as the related mechanisms.
View Article and Find Full Text PDFBackground: The prognostic significance of utilizing both the systemic inflammatory response index (SIRI) and pulse pressure (PP) collectively in assessing cardiovascular mortality (CVM) across populations remains to be elucidated.
Methods: Multivariate Cox proportional hazards analysis investigated the SIRI, PP, and CVM association. Receiver operating characteristic (ROC) curves evaluated the predictive performance of the combined SIRI and PP for CVM in the broader demographic.
Article Synopsis
- Photosynthesis is crucial for plant growth and the study focuses on a leaf color mutant of 'Benihoppe' strawberry, which has darker green leaves and enhanced chlorophyll and carotenoid levels, leading to a higher photosynthetic rate.
- Transcriptome analysis reveals that specific genes related to chloroplast development and chlorophyll synthesis are significantly upregulated in the mutant, while degradation genes are downregulated, resulting in greater chlorophyll accumulation.
- The study provides insights into the genetic mechanisms behind the dark-green leaf phenotype in strawberries, offering potential resources for developing new varieties with improved photosynthetic efficiency.
Leaf chlorosis caused by rootstock-scion incompatibility in citrus orchard badly affects fruit yield and quality. Starch excess and its key genes underlying citrus leaf chlorosis in incompatible graft remained unknown. Here, using created model incompatible/ compatible rootstock-scion combinations, we investigated starch content and distribution in 116 various chlorotic leaves of incompatible graft, and characterized the relationship between leaf chlorosis and starch accumulation.
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- Brown adipose tissue (BAT) is essential for producing heat in the body without shivering, making it a potential target for obesity and metabolic disease treatments.
- The study identifies SOX4 as a crucial factor for the development and function of BAT; its absence leads to loss of fatty tissue's heat-generating properties and increased vulnerability to obesity.
- SOX4 promotes the activity of EBF2, a gene important for brown fat formation, and its phosphorylation by PKA aids in its function, highlighting SOX4's key role in regulating thermogenesis in brown fat cells.
Article Synopsis
- Sirtuins (SRTs) are special proteins that help manage energy in plants, but we don't know much about them in crops like strawberries.
- Researchers discovered that a specific protein called FaSRT2-1 helps strawberries grow better, taste sweeter, and ripen faster.
- FaSRT2-1 works together with other proteins to increase energy and different nutrients in the fruit, making it tastier and improving its quality as it ripens.
Article Synopsis
- Hematopoietic stem cells are crucial for producing blood cells but are vulnerable to damage from ionizing radiation, which can lead to acute radiation syndrome (ARS) in victims.
- Researchers developed an injectable hydrogel combining Arg-Gly-Asp-alginate and Laponite that slowly releases interleukin-12, significantly improving survival rates and blood cell recovery in irradiated mice.
- The treatment enhances a specific signaling pathway that promotes the growth and repair of bone marrow cells, providing a potential new therapy for treating radiation-induced blood injury.
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- Testicular macrophages (TM) help the immune system in the testes and also might be able to make testosterone, a hormone that's important for many body functions.
- Research showed that TM can produce testosterone by expressing important enzymes needed for its creation.
- Removing TM in mice led to lower testosterone levels, showing they are important for keeping testosterone levels normal, and a protein called Cebpb helps control this process.
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- * The 10 mg·L concentration of sodium selenite promoted plant growth, while 40 mg·L significantly improved fruit weight, sweetness, and antioxidant properties, along with changes in sugar and acid metabolism.
- * The findings suggest that sodium selenite treatment can enhance both plant growth and fruit quality in strawberries, indicating its potential use for better nutrient supplementation.
Article Synopsis
- - This study compares two types of strawberries from China, 'Benihoppe' (red) and 'Fenyu No.1' (pink), analyzing their taste and texture based on biochemical and molecular differences using advanced techniques.
- - 'Benihoppe' strawberries are firmer with higher levels of sucrose and a specific pigment (P3G), while 'Fenyu No.1' contains more fructose, glucose, and various acids, showing distinct flavor profiles and biochemical composition.
- - The research also identified how genetic differences affect the synthesis and breakdown of various compounds in each strawberry type, revealing important insights for improving strawberry quality through metabolic regulation.
Article Synopsis
- The study focuses on the R2R3-MYB gene family in Chinese cherry, a fruit species known for its varied colors, to understand factors influencing its fruit color variation.
- Researchers identified 1490 R2R3-MYB genes categorized into 43 subfamilies, revealing species-specific expansions and evolutionary patterns in these genes compared to related species and Arabidopsis thaliana.
- The findings highlight the roles of two specific MYB genes, CpMYB10, which promotes anthocyanin production, and CpMYB4, which inhibits it, providing insights into the molecular mechanisms of fruit color variation in Chinese cherry.
Article Synopsis
- Postoperative delirium (POD) occurs in about 0.97% of patients after revision total knee arthroplasty (rTKA), with its highest incidence recorded at 1.31% in 2013; factors such as advanced age and numerous health issues increase this risk.
- The study analyzed 127,400 rTKA patients using the National Inpatient Sample database from 2010 to 2019, considering demographics, hospital type, pre-existing conditions, and complications during surgery.
- Patients experiencing POD had longer hospital stays, higher costs, and more in-hospital mortality, with complications ranging from cardiac issues to surgical problems like infections and wound complications.
Article Synopsis
- Fruit softening, crucial for shelf life and market value, is largely influenced by the polygalacturonase (PG) gene family, which has not been fully explored in strawberries.
- In a study of the octoploid strawberry genome, 75 PG genes were identified, categorized into three groups, and found mostly in the plasma membrane, cytoplasm, and chloroplasts.
- Among these genes, FxaC_21g15770 showed significant expression changes during ripening and was silenced to improve fruit firmness without affecting other quality traits, indicating its key role in strawberry softening.
Article Synopsis
- The study aimed to compare the effectiveness of video-based rehabilitation programs to traditional face-to-face interventions for individuals with schizophrenia, particularly those in remote areas.
- A randomized controlled trial involved 80 patients, divided into three groups: a control group, a face-to-face group, and a remote video group, measuring various assessment parameters.
- Results showed significant improvements in psychiatric symptoms and social functioning from both intervention groups, indicating that video rehabilitation is a viable alternative to in-person therapy for patients in early schizophrenia recovery.
The importance of rootstock in citrus production lies in its crucial role in determining tree growth, environmental stress tolerance, and fruit quality. Siebold ex Tanaka cv. Shuzhen No.
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- - Pulmonary hypertension (PH) is a serious condition that involves changes in the blood vessels of the lungs, leading to obstruction, and relies heavily on the phosphodiesterase 4 (PDE4) family of enzymes, which break down cyclic AMP (cAMP).
- - Researchers found that PDE4B, a specific subtype of PDE4, is mainly present in the lung endothelial cells and is increased in PH conditions; its role is crucial for the vascular changes seen in PH.
- - Treatment with a PDE4B-specific inhibitor showed promise in reducing PH symptoms in rats, highlighting the potential for targeted therapies that focus on PDE4B to treat this dangerous disorder.
Article Synopsis
- Sirtuins (SRTs) are deacetylases involved in regulating proteins, and the study focuses on FaSRT1-2 in strawberries, which plays a significant role in fruit ripening and plant growth.
- Transiently overexpressing FaSRT1-2 led to quicker fruit ripening, higher levels of sugars and anthocyanins, and increased growth, but made plants more vulnerable to heat stress and disease.
- The research also showed that FaSRT1-2 affects hormone levels and gene expression, indicating its dual role in promoting growth while undermining stress resistance in strawberry plants.
Article Synopsis
- LEA proteins in plants, particularly in strawberries, are essential for growth, stress response, and fruit ripening, with limited research exploring their comprehensive roles in these processes.
- The study identified 266 LEA proteins in the strawberry genome, mainly located in chloroplasts, cytoplasm, and nucleus, and found that gene duplication was a key factor in the LEA family's expansion, with specific subgroups playing significant roles in fruit development and ripening.
- Notably, the LEA1 group member FaLEA167 was linked to altered fruit maturation, inhibiting red coloration and anthocyanin content while increasing citric acid levels, suggesting potential applications in controlling fruit ripening
Article Synopsis
- The study evaluated the effects of 5, 10, and 15 mM GABA on the postharvest quality of strawberries, finding no changes in skin color or firmness but reduced weight loss at 10 mM compared to control.
- GABA treatment notably increased levels of sugars, acids, antioxidant enzyme activities, and beneficial compounds like anthocyanins and flavonoids, particularly at the 10 mM concentration.
- Overall, the results suggest that applying 10 mM GABA could enhance the postharvest quality and marketability of strawberries.
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- The study examines how exposure to nonylphenol (NP) during the perinatal period affects heart fibrosis in adult rat offspring and highlights the role of the TGF-β1/LIMK1 signaling pathway.
- Histopathological results showed increased collagen levels and impaired heart function in NP-exposed rats, with various fibrosis-related proteins and genes being upregulated.
- The findings suggest that NP exposure activates the TGF-β1/LIMK1 pathway, contributing to myocardial fibrosis in cardiac fibroblasts, and the use of a LIMK1 inhibitor was able to reduce this effect.
Article Synopsis
- - The study analyzes COVID-19 transmission in Lanzhou, China, using detailed data to understand the spatial and temporal dynamics of the virus's spread in urban areas.
- - By creating transmission networks and identifying key factors like superspreaders and peak transmission times, the research highlights how social interactions and busy locations contribute to virus propagation.
- - The findings suggest that early intervention strategies can effectively limit the spread of the pandemic, informing future policies aimed at developing resilient urban environments in the face of public health emergencies.
Background: Pulmonary hypertension (PH) is a progressive cardiopulmonary disease with a high mortality rate. Although growing evidence has revealed the importance of dysregulated energetic metabolism in the pathogenesis of PH, the underlying cellular and molecular mechanisms are not fully understood. In this study, we focused on ME1 (malic enzyme 1), a key enzyme linking glycolysis to the tricarboxylic acid cycle.
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