Publications by authors named "Luo Ya"
Background: With the increasing risk of nuclear exposure, more attention has been paid to the prevention and treatment of acute radiation syndrome (ARS). Although amino acids are key nutrients involved in hematopoietic regulation, the impacts of amino acids on bone marrow hematopoiesis following irradiation and the associated mechanisms have not been fully elucidated. Hence, it is of paramount importance to study the changes in amino acid metabolism after irradiation and their effects on hematopoiesis as well as the related mechanisms.
View Article and Find Full Text PDFBackground: The prognostic significance of utilizing both the systemic inflammatory response index (SIRI) and pulse pressure (PP) collectively in assessing cardiovascular mortality (CVM) across populations remains to be elucidated.
Methods: Multivariate Cox proportional hazards analysis investigated the SIRI, PP, and CVM association. Receiver operating characteristic (ROC) curves evaluated the predictive performance of the combined SIRI and PP for CVM in the broader demographic.
Photosynthesis is a source of energy for various types of plant life activities and is essential for plant growth and development. Consequently, the study of photosynthetic mechanisms has been a hot spot. Leaf color mutants has always been ideal materials for exploring the mechanisms of chlorophyll metabolism and photosynthesis.
View Article and Find Full Text PDFLeaf chlorosis caused by rootstock-scion incompatibility in citrus orchard badly affects fruit yield and quality. Starch excess and its key genes underlying citrus leaf chlorosis in incompatible graft remained unknown. Here, using created model incompatible/ compatible rootstock-scion combinations, we investigated starch content and distribution in 116 various chlorotic leaves of incompatible graft, and characterized the relationship between leaf chlorosis and starch accumulation.
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- Brown adipose tissue (BAT) is essential for producing heat in the body without shivering, making it a potential target for obesity and metabolic disease treatments.
- The study identifies SOX4 as a crucial factor for the development and function of BAT; its absence leads to loss of fatty tissue's heat-generating properties and increased vulnerability to obesity.
- SOX4 promotes the activity of EBF2, a gene important for brown fat formation, and its phosphorylation by PKA aids in its function, highlighting SOX4's key role in regulating thermogenesis in brown fat cells.
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- Sirtuins (SRTs) are special proteins that help manage energy in plants, but we don't know much about them in crops like strawberries.
- Researchers discovered that a specific protein called FaSRT2-1 helps strawberries grow better, taste sweeter, and ripen faster.
- FaSRT2-1 works together with other proteins to increase energy and different nutrients in the fruit, making it tastier and improving its quality as it ripens.
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- Hematopoietic stem cells are crucial for producing blood cells but are vulnerable to damage from ionizing radiation, which can lead to acute radiation syndrome (ARS) in victims.
- Researchers developed an injectable hydrogel combining Arg-Gly-Asp-alginate and Laponite that slowly releases interleukin-12, significantly improving survival rates and blood cell recovery in irradiated mice.
- The treatment enhances a specific signaling pathway that promotes the growth and repair of bone marrow cells, providing a potential new therapy for treating radiation-induced blood injury.
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- Testicular macrophages (TM) help the immune system in the testes and also might be able to make testosterone, a hormone that's important for many body functions.
- Research showed that TM can produce testosterone by expressing important enzymes needed for its creation.
- Removing TM in mice led to lower testosterone levels, showing they are important for keeping testosterone levels normal, and a protein called Cebpb helps control this process.
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- * The 10 mg·L concentration of sodium selenite promoted plant growth, while 40 mg·L significantly improved fruit weight, sweetness, and antioxidant properties, along with changes in sugar and acid metabolism.
- * The findings suggest that sodium selenite treatment can enhance both plant growth and fruit quality in strawberries, indicating its potential use for better nutrient supplementation.
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- - This study compares two types of strawberries from China, 'Benihoppe' (red) and 'Fenyu No.1' (pink), analyzing their taste and texture based on biochemical and molecular differences using advanced techniques.
- - 'Benihoppe' strawberries are firmer with higher levels of sucrose and a specific pigment (P3G), while 'Fenyu No.1' contains more fructose, glucose, and various acids, showing distinct flavor profiles and biochemical composition.
- - The research also identified how genetic differences affect the synthesis and breakdown of various compounds in each strawberry type, revealing important insights for improving strawberry quality through metabolic regulation.
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- The study focuses on the R2R3-MYB gene family in Chinese cherry, a fruit species known for its varied colors, to understand factors influencing its fruit color variation.
- Researchers identified 1490 R2R3-MYB genes categorized into 43 subfamilies, revealing species-specific expansions and evolutionary patterns in these genes compared to related species and Arabidopsis thaliana.
- The findings highlight the roles of two specific MYB genes, CpMYB10, which promotes anthocyanin production, and CpMYB4, which inhibits it, providing insights into the molecular mechanisms of fruit color variation in Chinese cherry.
Background: Postoperative delirium (POD) is a common surgical complication. However, the incidence and risk factors associated with postoperative delirium after revision total knee arthroplasty (rTKA) have not been comprehensively explored through extensive national databases.
Methods: Utilizing the National Inpatient Sample (NIS), the largest comprehensive U.
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- Fruit softening, crucial for shelf life and market value, is largely influenced by the polygalacturonase (PG) gene family, which has not been fully explored in strawberries.
- In a study of the octoploid strawberry genome, 75 PG genes were identified, categorized into three groups, and found mostly in the plasma membrane, cytoplasm, and chloroplasts.
- Among these genes, FxaC_21g15770 showed significant expression changes during ripening and was silenced to improve fruit firmness without affecting other quality traits, indicating its key role in strawberry softening.
Aim: This study aimed to establish a comprehensive set of recovery-oriented rehabilitation programs for individuals with schizophrenia, comparing the efficacy of video-based rehabilitation to traditional face-to-face interventions. The primary objective was to assess whether video-based rehabilitation could serve as a viable alternative for individuals with schizophrenia residing in remote areas.
Methods: A randomized controlled study was used to recruit 80 patients with schizophrenia in a stable post-hospitalization stage following discharge.
The importance of rootstock in citrus production lies in its crucial role in determining tree growth, environmental stress tolerance, and fruit quality. Siebold ex Tanaka cv. Shuzhen No.
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- - Pulmonary hypertension (PH) is a serious condition that involves changes in the blood vessels of the lungs, leading to obstruction, and relies heavily on the phosphodiesterase 4 (PDE4) family of enzymes, which break down cyclic AMP (cAMP).
- - Researchers found that PDE4B, a specific subtype of PDE4, is mainly present in the lung endothelial cells and is increased in PH conditions; its role is crucial for the vascular changes seen in PH.
- - Treatment with a PDE4B-specific inhibitor showed promise in reducing PH symptoms in rats, highlighting the potential for targeted therapies that focus on PDE4B to treat this dangerous disorder.
Sirtuins (SRTs) are a group of nicotinamide adenine dinucleotide (NAD)-dependent deacetylase that target both histone and nonhistone proteins. The biological function of SRT in horticultural plants has been rarely studied. In this study, FaSRT1-2 was identified as a key member of the 8 FaSRTs encoded in cultivated strawberry genome.
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- LEA proteins in plants, particularly in strawberries, are essential for growth, stress response, and fruit ripening, with limited research exploring their comprehensive roles in these processes.
- The study identified 266 LEA proteins in the strawberry genome, mainly located in chloroplasts, cytoplasm, and nucleus, and found that gene duplication was a key factor in the LEA family's expansion, with specific subgroups playing significant roles in fruit development and ripening.
- Notably, the LEA1 group member FaLEA167 was linked to altered fruit maturation, inhibiting red coloration and anthocyanin content while increasing citric acid levels, suggesting potential applications in controlling fruit ripening
The capability of 5, 10, 15 mM γ-aminobutyric acid (GABA) to improve the postharvest quality and antioxidant system of strawberry was evaluated in this study. The application of GABA had no effect on fruit skin color and firmness. The weight loss in fruits treated with 10 mM GABA was significantly lower than the control.
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- The study examines how exposure to nonylphenol (NP) during the perinatal period affects heart fibrosis in adult rat offspring and highlights the role of the TGF-β1/LIMK1 signaling pathway.
- Histopathological results showed increased collagen levels and impaired heart function in NP-exposed rats, with various fibrosis-related proteins and genes being upregulated.
- The findings suggest that NP exposure activates the TGF-β1/LIMK1 pathway, contributing to myocardial fibrosis in cardiac fibroblasts, and the use of a LIMK1 inhibitor was able to reduce this effect.
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- - The study analyzes COVID-19 transmission in Lanzhou, China, using detailed data to understand the spatial and temporal dynamics of the virus's spread in urban areas.
- - By creating transmission networks and identifying key factors like superspreaders and peak transmission times, the research highlights how social interactions and busy locations contribute to virus propagation.
- - The findings suggest that early intervention strategies can effectively limit the spread of the pandemic, informing future policies aimed at developing resilient urban environments in the face of public health emergencies.
Background: Pulmonary hypertension (PH) is a progressive cardiopulmonary disease with a high mortality rate. Although growing evidence has revealed the importance of dysregulated energetic metabolism in the pathogenesis of PH, the underlying cellular and molecular mechanisms are not fully understood. In this study, we focused on ME1 (malic enzyme 1), a key enzyme linking glycolysis to the tricarboxylic acid cycle.
View Article and Find Full Text PDFPbMYB1L enhances the cold tolerance and anthocyanin accumulation of transgenic Arabidopsis by regulating the expression of genes related to the cold-responsive genes pathway and anthocyanin synthesis pathway. MYB transcription factors (TFs) have been demonstrated to play diverse roles in plant growth and development. In the present study, we identified a novel R2R3-MYB transcription factor, PbMYB1L, from the peel of 'Red Zaosu' pear (Pyrus bretschneideri), which was induced by cold stress and acted as a positive regulator in anthocyanin biosynthesis.
View Article and Find Full Text PDFAnthocyanins widely accumulate in the vegetative and reproductive tissues of strawberries and play an important role in stress resistance and fruit quality. Compared with other fruits, little is known about the molecular mechanisms regulating anthocyanin accumulation in strawberry vegetative tissues. In this study, we revealed an R2R3-MYB transcription factor, FaMYB10-like (FaMYB10L), which positively regulated anthocyanin accumulation and was induced by light in the petiole and runner of cultivated strawberry.
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