Molecular dynamics simulations reveal concentration-dependent blockage of graphene quantum dots to water channel protein openings.

Graphene quantum dots (GQDs) have attracted significant attention across various scientific research areas due to their exceptional properties. However, studies on the potential toxicity of GQDs have yielded conflicting results. Therefore, a comprehensive evaluation of the toxicity profile of GQDs is essential for a thorough understanding of their biosafety.

Genomic and transcriptomic landscape of human gastrointestinal stromal tumors.

Gastrointestinal stromal tumor (GISTs) are clinically heterogenous exhibiting varying degrees of disease aggressiveness in individual patients. We comprehensively describe the genomic and transcriptomic landscape of a cohort of 117 GISTs including 31 low-risk, 18 intermediate-risk, 29 high-risk, 34 metastatic and 5 neoadjuvant GISTs from 105 patients. GISTs have notably low tumor mutation burden but widespread copy number variations.

A R2R3-MYB transcription factor, FeR2R3-MYB, positively regulates anthocyanin biosynthesis and drought tolerance in common buckwheat (Fagopyrum esculentum).

The R2R3-MYB transcription factors (TFs) play a crucial role in regulating plant secondary metabolism and abiotic stress responses, yet they are still poorly understood in common buckwheat (Fagopyrum esculentum), a valuable minor grain crop resource. In this study, a candidate gene, FeR2R3-MYB, was cloned from the anthocyanin-rich common buckwheat variety 'QZZTQ'. FeR2R3-MYB was found to contain two MYB DNA-binding domains and be located at the nucleus with transcriptional activation activity.

Baricitinib inhibits the activation of innate immune cells and exerts therapeutic effects on acute peritonitis and systemic inflammatory response syndrome.

Timely treatment of acute inflammatory diseases induced by bacteria or fungi is essential to prevent infectious damage. Baricitinib is an inhibitor of Janus kinases (JAKs) which was approved to treat rheumatoid arthritis, atoptic dermatitis, and alopecia areata. It is also known that JAKs play important roles in innate immunity and inflammatory response.

Poria cocos-derived carbon dots for parallel detection of Cr/Fe in complex environments with superior sensitivity.

Multifunctional sensor capable of parallel sensing is of great importance thanks to their wide applications and great practicality. In this report, Poria cocos-derived carbon dots (CDs) were adopted for the development of multifunctional sensor for the parallel detection of Cr and Fe with superior sensitivity and applicability. Specifically, extremely low limit of detection (LOD) of 1.

Radiomics based on MRI in predicting lymphovascular space invasion of cervical cancer: a meta-analysis.

Objective: The objective of this meta-analysis is to assess the efficacy of radiomics techniques utilizing magnetic resonance imaging (MRI) for predicting lymphovascular space invasion (LVSI) in patients with cervical cancer (CC).

Methods: A comprehensive literature search was conducted in databases including PubMed, Embase, Cochrane Library, Medline, Scopus, CNKI, and Wanfang, with studies published up to 08/04/2024, being considered for inclusion. The meta-analysis was performed using Stata 15 and Review Manager 5.

Endosomal Trafficking Bypassed by the RAB5B-CD109 Interplay Promotes Axonogenesis in KRAS-Mutant Pancreatic Cancer.

Perineural invasion (PNI) represents a unique biological feature associated with poor prognosis in pancreatic ductal adenocarcinoma (PDAC), especially in the presence of KRAS mutations. Extracellular vesicle (EV)-packaged circular RNAs (circRNAs) function as essential mediators of tumor microenvironment communication, triggering PDAC cell invasion and distant metastasis. However, the regulatory mechanisms of EV-packaged circRNAs in the PNI of KRAS-mutant PDAC have not yet been elucidated.

Numerical modeling and parametric analysis of temperature distribution in soil based on water content variation under radio frequency heating for in-situ thermal remediation.

Radio frequency heating (RFH) is recognized as an efficient and economical method for volatilizing organic pollutants from contaminated soils. Although some numerical simulations have been conducted to predict temperature changes during RFH, models that account for effects of water content (WC) variation on dielectric properties and temperature evolution in soil were rarely reported. To address this, a three-dimensional numerical model integrating electromagnetic-thermal conversion, heat transfer, and mass transfer was developed with coupling dynamic changes in WC and corresponding impacts on soil properties.

Comparative efficacy of anthracycline-free and anthracycline-containing neoadjuvant chemoimmunotherapy regimens for triple-negative breast cancer.

Background: The selection of appropriate chemotherapy backbone agents in combination with neoadjuvant immunotherapy for triple-negative breast cancer (TNBC) remains unclear. Herein, we aimed to evaluate the efficacy and safety of anthracycline-free and anthracycline-containing regimens coupled with neoadjuvant immunotherapy.

Method: This retrospective study included 87 patients with TBNC who received neoadjuvant immunotherapy combined with various chemotherapy regimens at three research centers from November 2020 to November 2023.

The starch excess and key genes underlying citrus leaf chlorosis by rootstock-scion incompatibility.

Leaf chlorosis caused by rootstock-scion incompatibility in citrus orchard badly affects fruit yield and quality. Starch excess and its key genes underlying citrus leaf chlorosis in incompatible graft remained unknown. Here, using created model incompatible/ compatible rootstock-scion combinations, we investigated starch content and distribution in 116 various chlorotic leaves of incompatible graft, and characterized the relationship between leaf chlorosis and starch accumulation.

Long-term, automated stool monitoring using a novel smart toilet: A feasibility study.

Background: Patients' report of bowel movement consistency is unreliable. We demonstrate the feasibility of long-term automated stool image data collection using a novel Smart Toilet and evaluate a deterministic computer-vision analytic approach to assess stool form according to the Bristol Stool Form Scale (BSFS).

Methods: Our smart toilet integrates a conventional toilet bowl with an engineered portal to image feces in a predetermined region of the plumbing post-flush.

Realizing linear-polarization-decoupled quasi-perfect absorption through mirror-symmetric QR-code metasurfaces.

Metamaterial absorbers (MAs) with irregular structures facilitate the attainment of unique absorption properties, leveraging the extensive geometric freedom. However, a challenge arises from the fact that polarization-dependent spectra do not coincide with cross-polarization. In this study, we introduce a MA featuring a mirror-symmetric quick response (QR)-code structure to achieve linear-polarization-decoupled absorption characteristics.

Attention allocation in foreign language reading anxiety during lexical processing - An ERP study with cue-target paradigm.

Extensive behavioral and pedagogical studies emphasize the negative impact of foreign language reading anxiety on foreign language reading. This study investigated whether foreign language reading anxiety is correlated with dysregulation of attentional allocation while foreign language reading. We used event-related potential (ERP) indices as biomarkers to examine attention allocation between groups with high foreign language reading anxiety (HFLRA) and low foreign language reading anxiety (LFLRA) using a cue-target paradigm under conditions that posed high (valid condition) or low (invalid condition) expectations on target location.

Aerobic Thiols Oxidative Coupling to Disulfides over Robust CoO Nanoclusters Confined within Hierarchical Silicalite-1 Zeolite.

Disulfide is an important organic reagent and synthetic intermediate that is widely used in organic synthesis, polymers, and other fields, but its synthesis still suffers from many environmental pollution and economic problems. Here, we present an environmentally friendly and efficient base-free aerobic oxidative thiol coupling catalyzed by heterogeneous CoO nanoclusters entrapped in hierarchical silicalite-1 zeolite, synthesized by combining silane pore expansion and metal coordination methods under hydrothermal conditions. It is confirmed that open hierarchical channels favor mass diffusion, and the chemical valence of Co species in CoO/-S-1-H is +2, which is different from that of CoO particles in CoO/-S-1-I.

Interfacial microstructure and corrosion behavior of ODS FeCrAl alloy in oxygen-saturated lead-bismuth eutectic at 450 °C.

The interfacial microstructure and corrosion behavior of oxide dispersion strengthening (ODS) FeCrAl alloy with 20 wt% Cr (e.g. 20Cr ODS FeCrAl alloy) exposed to static oxygen-saturated lead-bismuth eutectic (LBE) at 450 °C for 20 h, 40 h, 60 h, 80 h and 100 h as exposure time respectively have been investigated.

Silencing CCT3 induces ferroptosis through the NOD1-NF-κB signaling pathway in bladder cancer.

Bladder cancer (BCa) is a lethal malignancy of the urinary system and exhibits a poor prognosis. Chaperonin-containing tailless complex polypeptide 1 subunit 3 (CCT3) acts as an oncogene in various tumors, whereas its effect on BCa remains unknown. We identified the ferroptosis-associated differentially expressed genes through bioinformatic analysis and selected CCT3 for further verification.