Zero-Dimensional Plastic Phase Transition Iron-Based Compounds with High and Switchable SHG Responses.

Organic-inorganic hybrid materials have garnered significant interest due to their unique combination of phase transition characteristics, substantial entropy changes, simple preparation methods, and structural flexibility, making them promising candidates for applications in sensor technologies and data storage systems. In the present research, two plastic organic-inorganic hybrid phase transition materials: [CHNF]FeCl () and [CHNF]FeBr () were successfully synthesized by the H/F substitution strategy. Significant step-like dielectric changes were observed during the reversible phase transitions of (401 K) and (406 K).

Measurements of tenofovir-diphosphate and emtricitabine-triphosphate concentrations in dried blood spots of people receiving pre-exposure prophylaxis for HIV with co-formulated tenofovir disoproxil fumarate and emtricitabine.

Background/purpose(s): Data regarding the concentrations of tenofovir-diphosphate (TFV-DP) and emtricitabine-triphosphate (FTC-TP) in the Asian population receiving pre-exposure prophylaxis (PrEP) for HIV with tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC) (TDF/FTC) are limited, and the associations between the frequency of TDF/FTC administration and drug concentration among people receiving on-demand PrEP remain unclear.

Methods: Fifty-seven participants receiving daily TDF/FTC and 113 participants receiving on-demand TDF/FTC were enrolled in this study. The concentrations of TFV-DP and FTC-TP were measured in dried blood spots using liquid chromatography‒mass spectrometry.

An Immune-Liver Microphysiological System Method for Evaluation and Quality Control of Hepatotoxicity Induced by Polygonum multiflorum Thunb. Extract.

Ethnopharmacological Relevance: Clinical applications of Polygonum multiflorum Thunb. (PMT) have occasionally reported adverse effects on liver function, linking these instances of hepatotoxicity to PMT samples. Evaluating the hepatotoxicity of PMT, given its intricate composition and mechanisms, presents a notable challenge.

Netrin-1 binding to UNC5b improves post-stroke neuronal ferroptosis via AMPK-BACH1 pathway.

Ferroptosis contributes to neuronal destruction after ischemic stroke which may be improved by inhibiting BTB domain and CNC homologue 1 (BACH1), a recently recognized ferroptosis facilitator. Axon guidance molecule netrin-1 (Ntn1) functions in neuroprotection against ischemic insult by engaging into its receptor of uncoordinated-5 homolog B (UNC5b) via adenosine 5'-monophosphate-activated protein kinase (AMPK), which potentially binds to BACH1. Whether Ntn1/UNC5b regulates post-stroke ferroptosis through AMPK-BACH1 pathway remains unclear.

Long-lasting pigment fixation of ancient paintings using hydrophilic microgels prepared from hydroxyethyl cellulose and sodium alginate.

The long-term fixation of mineral pigments in ancient paintings has always been a challenge. Gelatin alum solution (GAW), as a traditional pigment fixative, presents good pigment fixation in the early stage of use, but its poor durability is well known. In this work, a microgel (SH) prepared from sodium alginate and hydroxyethyl cellulose was proposed to replace GAW for the pigment fixation due to its micro scale, strong adhesion, and good chemical stability.

Associations of protein intake with the risk of fractures: A prospective cohort study of UK biobank participants.

Purpose: To evaluate the associations between protein intake and fractures risk in a large population-based cohort.

Methods: We conducted a prospective population-based study of UK Biobank. Participants aged 40-69 who completed the Oxford WebQ dietary questionnaire at least once were included.

Encapsulation of FeS within N/S-Doped bamboo-like carbon nanotubes for facilitated rapid catalytic conversion of polysulfides in high-performance lithium-sulfur batteries.

Lithium-sulfur batteries (LSBs) are considered to be competitive next-generation electrochemical energy storage devices, but their practical application is severely hampered by the shuttle effect and slow redox kinetics of soluble lithium polysulfides (LiPSs). To address this challenge, FeS encapsulated within N/S co-doped bamboo-like carbon nanotubes (FeS/NSC) is synthesized via a pyrolysis sulfidation process, and act as a coating separator for LSBs. The 1-dimensional (1D) S and N co-doped carbon substrate materials can act as conductive networks, exposing more adsorption sites and enhancing the capture of LiPSs.

Measurement of Very-High-Energy Diffuse Gamma-Ray Emissions from the Galactic Plane with LHAASO-WCDA.

The diffuse Galactic gamma-ray emission is a very important tool used to study the propagation and interaction of cosmic rays in the Milky Way. In this Letter, we report the measurements of the diffuse emission from the Galactic plane-covering Galactic longitudes from 15° to 235° and latitudes from -5° to +5°, in an energy range of 1 to 25 TeV-made with the Water Cherenkov Detector Array (WCDA) of the Large High Altitude Air Shower Observatory. After the sky regions of known sources are masked, the diffuse emission is detected with 24.

Search for the K_{L}→π^{0}νν[over ¯] Decay at the J-PARC KOTO Experiment.

We performed a search for the K_{L}→π^{0}νν[over ¯] decay using the data taken in 2021 at the J-PARC KOTO experiment. With newly installed counters and new analysis method, the expected background was suppressed to 0.252±0.

First Determination of the Spin-Parity of Ξ_{c}(3055)^{+,0} Baryons.

The Ξ_{b}^{0(-)}→Ξ_{c}(3055)^{+(0)}(→D^{+(0)}Λ)π^{-} decay chains are observed, and the spin-parity of Ξ_{c}(3055)^{+(0)} baryons is determined for the first time. The measurement is performed using proton-proton collision data at a center-of-mass energy of sqrt[s]=13  TeV, corresponding to an integrated luminosity of 5.4  fb^{-1}, recorded by the LHCb experiment between 2016 and 2018.

Tc-Labeled Quinolone-Based Novel Skeletal Tracers for Tumor Visualization through Fibroblast Activation Protein.

Fibroblast activation protein (FAP) has emerged as a prominent target for tumor diagnosis. Quinoline-based FAP PET tracers demonstrated clinical feasibility. However, there is a relative scarcity of clinical studies on Tc-labeled FAP SPECT tracers.

AGTR1 potentiates the chemotherapeutic efficacy of cisplatin in esophageal carcinoma through elevation of intracellular Ca and induction of apoptosis.

Cisplatin is one of the principal chemotherapeutic agents used for esophageal cancer (EC) treatment; however, EC mortality remains high. It is therefore imperative to find new therapeutic targets and approaches to potentiate the chemotherapeutic efficacy of cisplatin. Angiotensin II receptor type 1 (AGTR1) is a potential therapeutic target in multiple cancer types.

Effects of essential amino acids availability on amino acids uptake, metabolism and casein synthesis in bovine mammary epithelial cells.

Under current dairy cow feeding conditions, the conversion efficiency of dietary nitrogen into milk protein is less than 30%. A thorough understanding of amino acid (AA) uptake and utilization in mammary in response to AA supply is essential for accurately modeling nutritional requirements. This study utilized bovine mammary epithelial cells (BMEC) as a model to investigate the effects of increasing total essential amino acid (EAA) concentrations (0.

Ergosterol originated from attenuates high fat diet-induced obesity and cognitive impairment in mice.

Excessive intake of a high fat diet (HFD) leads to accumulation of fat and obesity. Ergosterol (ERG) is a characteristic sterol of fungi with various bioactive functions; however, there are few studies on the ERG function of ameliorating obesity and following cognitive impairment. It was previously found that Zhashui (AA) is rich in ERG; therefore it was selected to enrich ERG through the intervention of exogenous inducers of rice bran oil (RBO), methyl jasmonate (Me JA) and salicylic acid (SA).

The structural basis of the G protein-coupled receptor and ion channel axis.

Sensory neurons play an essential role in recognizing and responding to detrimental, irritating, and inflammatory stimuli from our surroundings, such as pain, itch, cough, and neurogenic inflammation. The transduction of these physiological signals is chiefly mediated by G protein-coupled receptors (GPCRs) and ion channels. The binding of ligands to GPCRs triggers a signaling cascade, recruiting G proteins or β-arrestins, which subsequently interact with ion channels (e.

Mogroside V enhances bone marrow mesenchymal stem cells osteogenesis under hyperglycemic conditions through upregulating miR-10b-5p and PI3K/Akt signaling.

Background: Mogroside V (MV) is a triterpene glucoside that reportedly exhibits an array of antitumor, anti-inflammatory, hypolipidemic, and hypoglycemic properties. In prior studies, our group determined that MV was able to readily enhance osteogenic bone marrow mesenchymal stem cells (BMSCs) differentiation under high-glucose conditions through mechanisms potentially associated with miR-10b-5p and PI3K/Akt signaling activity. The precise molecular basis for these effects, however, remains to be fully elucidated.

Advances in rhabdomyolysis: A review of pathogenesis, diagnosis, and treatment.

Rhabdomyolysis (RM) is a multifactorial clinical syndrome characterized by the disintegration and necrosis of muscle tissue, leading to the release of cellular contents into the circulation. One of the most severe complications of RM is acute kidney injury, with a mortality rate of 20%-50%. Early and timely diagnosis is the key to improving the prognosis of patients with RM.

Association of maternal metabolic risk factors with offspring body mass index (BMI) trajectories in early childhood: a retrospective cohort study.

Objective: This study aimed to identify body mass index (BMI) growth trajectories from birth to 24 months of age and examine the independent and additive effects of four maternal metabolic risk factors, namely prepregnancy BMI, the rate of gestational weight gain, gestational diabetes mellitus (GDM) and gestational hypertension, on offspring growth trajectories in childhood in China.

Design: A retrospective cohort study was conducted.

Setting: The study used Maternal and Child Health Management Database in Chengdu, China, including the mothers' antenatal care data, birth certificate records and 0-3-year-old children's healthcare data.

Single-cell Raman spectroscopy as a novel platform for unveiling the heterogeneity of mesenchymal stem cells.

Despite the significant potential of mesenchymal stem cells (MSC) therapy in clinical settings, challenges persist regarding the efficient detection of consistency and uniformity of MSC populations. Raman spectroscopy is a fast, convenient, and nondestructive technique to acquire molecular properties of biomolecules across laboratory and mass-production settings. Here we utilized Raman spectroscopy to evaluate the heterogeneity of primary MSC from varying donors, passages, and distinct culture conditions, and compared its effectiveness with conventional techniques such as flow cytometry.

Cryo-EM reveals mechanisms of natural RNA multivalency.

Homo-oligomerization of biological macromolecules leads to functional assemblies that are critical to understanding various cellular processes. However, RNA quaternary structures have been rarely reported. Comparative genomics analysis has identified RNA families containing hundreds of sequences that adopt conserved secondary structures and likely fold into complex three-dimensional (3D) structures.

Medium-Chain Chlorinated Paraffins Induced Reproductive Toxicity in Female Rats by Interfering with Oocyte Meiosis and Triggering DNA Damage.

Medium-chain chlorinated paraffins (MCCPs) are among the most prevalent chemicals detected in human serum. As an emerging persistent organic pollutant, their toxicity mechanisms, particularly concerning the female reproductive system, remain poorly understood. In this study, we present both and evidence of ovarian toxicity induced by MCCPs and insights into their underlying molecular mechanisms.

A d-electron Deficient Pd Trimer for Exceptional Pyridine Hydrogenation Activity and Selectivity.

The selective hydrogenation of pyridines containing reducible groups such as 2-phenylpyridine typically has low yields due to strong nitrogen coordination with the metal as well as non-selective and over-hydrogenation. We report the synthesis of a novel Pd trimer catalyst through confined growth on an ordered mesoporous carrier, characterized by a 0.42 d-electron deficiency to address this challenge.

A multifunctional Pt/DMSN nanozyme-based colorimetric-fluorescence sensing platform for breast cancer detection.

Nanozyme-linked immunosorbent assay has emerged as a promising strategy for sensitive biosensing. However, the catalytic activity and stability of nanozymes affect the accuracy of immunosorbent assays. In this study, we synthesized a Pt/DMSN nanozyme with peroxidase-mimicking activity, which effectively catalyzed the oxidation of peroxidase substrate 3,3',5,5'-tetramethylbenzidin (TMB) in the presence of hydrogen peroxide.

A common longitudinal intensive care unit data format (CLIF) for critical illness research.

Rationale: Critical illness threatens millions of lives annually. Electronic health record (EHR) data are a source of granular information that could generate crucial insights into the nature and optimal treatment of critical illness.

Objectives: Overcome the data management, security, and standardization barriers to large-scale critical illness EHR studies.