Publications by authors named "Luo Xiao-Xin"
Article Synopsis
- - Atherosclerosis (AS) is a key cause of many ischemic cardiovascular diseases, initiated by damage to vascular endothelial cells, leading to inflammation, platelet activation, and the formation of plaque through processes involving monocytes and smooth muscle cells.
- - The excessive activation of autophagy in vascular and platelet cells can negatively impact plaque stability, suggesting that a precise regulation of these processes might offer new treatment avenues for AS.
- - Current AS treatments mainly rely on statins to lower lipid levels, which can have side effects, prompting research into safer therapies, including the use of traditional Chinese medicine and natural compounds that target autophagy.
Acute myocardial infarction(AMI) is still the leading cause of death worldwide. At present, the treatment of AMI is mainly to restore the cardiac blood supply through myocardial reperfusion. With the widespread use of coronary artery bypass grafting and percutaneous coronary intervention(PCI), myocardial reperfusion injury is a major clinical problem.
View Article and Find Full Text PDF[Construction of beta-catenin miRNA-expressing vectors and test of silencing effect in adipose-derived stem cells from Sprague-Dawley rats].
Sichuan Da Xue Xue Bao Yi Xue Ban
September 2014
Unlabelled: OBEJECTIVE: To construct miRNA-expressing plasmid vector for interfering the expression of beta-catenin in adipose-derived stem cells from Sprague-Dawley rats.
Methods: The double strands oligonucleotides of miR-expressing cassette were ligated into plasmid pSWH to generate pSWH-miR. Then the PCR product of enhanced green fluorescence protein (EGFP) open reading frame (ORF) fragment was inserted into BamH I and Xbo I digested pSWH-miR to generate pSWH-EGFP-miR.
Two new taxoids, 13,15-epoxy-13-epi-taxayunnasin A (1) and taxchinin N (2), were isolated from the leaves and stems of Taxus chinensis. Compound 2 is the first taxoid to be reported with an alpha,beta-unsaturated lactone at C-4, C-5, C-20, and C-2. The structure of 1 was elucidated by spectroscopic analysis and confirmed by semisynthesis from taxayunnasin A, while 2 was determined structurally using spectroscopic methods and by single-crystal X-ray diffraction.
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