Chromatin accessibility reveals potential prognostic value of the peak set associated with smoking history in patients with lung adenocarcinoma.

Considerable differences in molecular characteristics have been defined between non-smoker and smokers in patients with lung adenocarcinoma (LUAD), yet studies on open chromatin patterns associated with LUAD progression caused by smoking are still lacking. Here, we constructed a novel network based on correlations between each ATAC-seq peak from TCGA data using our previously developed algorithm. Subsequently, principal component analysis was performed on LUAD samples with retained peaks filtered by the correlation network, and pathway analysis was conducted to identify potential pathways involved.

Noncovalently Bridging Cell-Surface Proteins Using Synthetic Peptides to Modulate Cell Apoptosis.

Controlled high-order clustering of cell-surface proteins is an essential but unmatched regulatory mechanism in living systems for the modulation of cell behavior. Here, we present a strategy for generating extended and tunable one-dimensional clusters of death receptors on live cell surfaces by employing synthetic peptides to noncovalently bridging the proteins. The on-cell assembly process is validated through super-resolution fluorescence imaging and fluorescence lifetime imaging analyses.

Development of a Prognostic Nomogram for Nonneutropenic Invasive Pulmonary Aspergillosis Based on Machine Learning.

Background: The incidence of invasive pulmonary aspergillosis (IPA) is progressively rising in the nonneutropenic population, but studies investigating relevant prognostic factors remain scarce.

Methods: Participants who were hospitalized at Zhongshan City People's Hospital from January 2018 to May 2023 and diagnosed with nonneutropenic deficient IPA were included in this study. The least absolute shrinkage and selection operator (LASSO) regression and multivariate Cox regression methods were used to select variables for constructing the predictive model.

Omnidirectional path loss model for non-line-of-sight ultraviolet communications.

To analyze the channel characteristics in omnidirectional reception scenarios for non-line-of-sight ultraviolet (UV) communication, we derive expressions for the reception direction distribution based on the incident photons at the receiver and propose an omnidirectional reception path loss (PL) channel model based on the Monte Carlo (MC) method. Furthermore, we validate the proposed omnidirectional model by comparing it with the existing MC numerical model that traverses all reception directions. Results indicate that the average computation time of the proposed omnidirectional PL model is less than 0.

Novel food-grade water-in-water emulsion fabricated by amylopectin and tara gum: Property evaluation and stability analysis.

To surmount the limitation of the instability of the currently reported water-in-water (W/W) emulsions, novel W/W emulsionss were constructed using amylopectin (AMP) and tara gum (TG) as the phases, and differently shaped ovalbumin (OVA) particles were used as stabilizers to improve the stability of W/W emulsions. Experiments displayed that the conformation of OVA could be changed by heating treatment, thus forming fibrous or spherical OVA particles that had the potential to stabilize TG-in-AMP (TG/AMP) emulsions. The emulsions had the best stability when the pH was 4 and the concentration of OVA particles was 3 %.

Effect of fabrication methods and number of supporting teeth on the surface accuracy and dimensional stability of implant surgical guides.

Statement Of Problem: Implant surgical guides manufactured using different fabrication methods have been commonly used for computer-guided implant placement. However, how fabrication methods and the number of supporting teeth influence accuracy and stability remains uncertain.

Purpose: The purpose of this in vitro study was to evaluate the influence of fabrication methods and number of supporting teeth on the surface accuracy and dimensional stability of implant surgical guides with 3 different 3-dimensional (3D) printers and 1 computer numeric controlled (CNC) milling machine.

Ecological cooperative merging control of heterogeneous electric vehicle platoons.

Vehicle platooning improves energy savings via vehicle-to-vehicle (V2V) communication. Ecological cooperative adaptive cruise control (Eco-CACC) is implemented in platoons for merging task by using regrouped platoon models. The merging positions are selected in the middle and tail of an original platoon with a two-vehicle sub-platoon.

Immuno- and expression analysis of immunoreactive proteins.

is the primary etiologic agent of canine monocytic ehrlichiosis, a serious and sometimes fatal hemorrhagic disease of dogs. Diagnosis of infection is often retrospectively confirmed by serologic detection of antibodies by immunofluorescent microscopy. Our laboratory previously identified numerous major immunoreactive proteins with species-specific linear antibody epitopes that are useful for immunodiagnosis of CME.

Pharmacological Strategies and Surgical Management of Posthemorrhagic Hydrocephalus Following Germinal Matrix-Intraventricular Hemorrhage in Preterm Infants.

Germinal matrix-intraventricular hemorrhage (GM-IVH) is a detrimental neurological complication that occurs in preterm infants, especially in babies born before 32 weeks of gestation and in those with a very low birth weight. GM-IVH is defined as a rupture of the immature and fragile capillaries located in the subependymal germinal matrix zone of the preterm infant brain, and it can lead to detrimental neurological sequelae such as posthemorrhagic hydrocephalus (PHH), cerebral palsy, and other cognitive impairments. PHH following GM-IVH is difficult to treat in the clinic, and no levelone strategies have been recommended to pediatric neurosurgeons.

Prognostic genome and transcriptome signatures in colorectal cancers.

Colorectal cancer is caused by a sequence of somatic genomic alterations affecting driver genes in core cancer pathways. Here, to understand the functional and prognostic impact of cancer-causing somatic mutations, we analysed the whole genomes and transcriptomes of 1,063 primary colorectal cancers in a population-based cohort with long-term follow-up. From the 96 mutated driver genes, 9 were not previously implicated in colorectal cancer and 24 had not been linked to any cancer.

Establishing a Comprehensive Nursing Clinic Using the Case Management Model.

Objective: To explore the practical effect of the case management model in a comprehensive nursing clinic.

Methods: Based on the case management model, the authors constructed a comprehensive nursing clinic providing wound care, ostomy care, peripherally inserted central catheter care, drainage tube care, nursing consultations, and home care. They evaluated the practical effect of the comprehensive nursing clinic according to workload, economic benefits, and satisfaction of the medical staff and patients.

Pulse Design of Constant Strain Rate Loading in SHPB Based on Pulse Shaping Technique.

The Split Hopkinson pressure bar (SHPB) is widely used for characterizing the mechanical behavior of materials at high strain rates. One of the most challenging factors is achieving constant strain rate (CSR) loading of the specimen at a certain strain rate. Obtaining the effective incident pulse based on the experimental material for achieving CSR loading remains unresolved.

GLUT1 mediates bronchial epithelial E-cadherin disruption in TDI-induced steroid-insensitive asthma.

Objective: Down-regulation of bronchial epithelial E-cadherin is an important of feature of severe asthma, including steroid-insensitive asthma. Yet, the mechanisms involved in E-cadherin disruption are not fully understood. This study was aimed to investigate the role of glucose transporter 1 (GLUT1) in dysregulation of E-cadherin in toluene diisocyanate (TDI)-induced steroid-insensitive asthma.

New insights into evolution and functional diversification of LRR-RLKs.

Unlabelled: Leucine-rich repeat receptor-like kinases (LRR-RLKs) represent the largest subgroup of receptor-like kinases (RLKs) in plants. While some LRR-RLK members play a role in regulating various plant growth processes related to morphogenesis, disease resistance, and stress response, the functions of most LRR-RLK genes remain unclear. In this study, we identified 397 LRR-RLK genes from the genome of Camellia sinensis and categorized them into 16 subfamilies.

Three dimensionally printed template with an interproximal isolation design guide consecutive closure of multiple diastema with injectable resin composite.

Objective: This article describes a novel 3D-printed template armed with interproximal matrices to isolate interproximal contact areas and guide injectable resin composite for consecutive closure of multiple diastema.

Clinical Considerations: Among several treatment options proposed for diastema closure, direct resin composite is noninvasive and easy to repair. The "composite injection technique" has been introduced to improve time efficiency and reduce technique sensitivity for clinicians.

Global modified Delphi consensus on diagnosis, phenotypes, and treatment of SCN8A-related epilepsy and/or neurodevelopmental disorders.

Objective: We aimed to develop consensus for diagnosis/management of SCN8A-related disorders. Utilizing a modified Delphi process, a global cohort of experienced clinicians and caregivers provided input on diagnosis, phenotypes, treatment, and management of SCN8A-related disorders.

Methods: A Core Panel (13 clinicians, one researcher, six caregivers), divided into three subgroups (diagnosis/phenotypes, treatment, comorbidities/prognosis), performed a literature review and developed questions for the modified Delphi process.

Global modified-Delphi consensus on comorbidities and prognosis of SCN8A-related epilepsy and/or neurodevelopmental disorders.

Objectives: We aimed to develop consensus on comorbidities (frequency, severity, and prognosis) and overall outcomes in epilepsy, development, and cognition for the five phenotypes of SCN8A-related disorders.

Methods: A core panel consisting of 13 clinicians, 1 researcher, and 6 caregivers was formed and split into three workgroups. One group focused on comorbidities and prognosis.

All-Textile Piezoelectric Nanogenerator Based on 3D Knitted Fabric Electrode for Wearable Applications.

Flexible, air permeable and elastic self-powered sensors for human motion monitoring and assisted medical rehabilitation have recently become a hot research topic. However, most current piezoelectric sensors can not account for many characteristics. Addressing this challenge, an all-textile piezoelectric sensor (ATPS) based on 3D structured knitted fabric electrodes is reported.

Protection of Si Nanowires against A Toxicity by the Inhibition of A Aggregation.

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by the accumulation of amyloid beta (A) plaques in the brain. A is the main component of A plaque, which is toxic to neuronal cells. Si nanowires (Si NWs) have the advantages of small particle size, high specific surface area, and good biocompatibility, and have potential application prospects in suppressing A aggregation.

Multi-omics portrait of ductal carcinoma in situ in young women.

Background: Young patients with breast ductal carcinoma in situ (DCIS) often face a poorer prognosis. The genomic intricacies in young-onset DCIS, however, remain underexplored.

Methods: To address this gap, we undertook a comprehensive study encompassing exome, transcriptome, and vmethylome analyses.

A Review of Dynamic Mechanical Behavior and the Constitutive Models of Aluminum Matrix Composites.

Aluminum matrix composites (AMMCs) have demonstrated substantial potential in the realm of armor protection due to their favorable properties, including low density, high specific stiffness, and high specific strength. These composites are widely employed as structural components and frequently encounter high strain rate loading conditions, including explosions and penetrations during service. And it is crucial to note that under dynamic conditions, these composites exhibit distinct mechanical properties and failure mechanisms compared to static conditions.

Highly Stretchable and Multimodal MXene/CNTs/TPU Flexible Resistive Sensor with Hierarchical Structure Inspired by Annual Ring for Hand Rehabilitation.

With the advent of the intelligent age and people's higher pursuit of health, wearable sensors with functions of health monitoring and assisting physical rehabilitation are increasingly favored by consumers. Wherein, highly stretchable flexible sensors show promising potential, but the unstable conductivity under large strains remains a great challenge to develop flexible wearable sensors with both a wide work range and strain insensitivity. Based on this, a MXene/CNTs/TPU flexible resistive sensor (MCT/FRS) with hierarchical structure inspired by the annual ring was proposed.

Antibody reactive immunomes of and are diverse and defined by conformational antigenic determinants.

For decades, the defined antibody reactive proteins of and were limited to a small group with linear antibody epitopes. Recently, our laboratory has utilized an immunomics-based approach to rapidly screen and identify undefined and antigenic proteins and antibody epitopes. In this study, we analyzed the remaining portion (~50%) of the and proteomes ( = 444 and 405 proteins, respectively), that were not examined in previous studies, to define the complete immunomes of these important pathogens.

Continuous Refinement-based Digital Pathology Image Assistance Scheme in Medical Decision-Making Systems.

Digital pathology images' extensive cellular information provide a trustworthy foundation for tumor diagnosis. With the aid of computer-aided diagnostics, pathologists can locate crucial information more quickly. The cascade structure refines the segmentation results by utilizing its multi-task and multi-stage characteristics.