KLF2 controls the apoptosis of neutrophils and is associated with disease activity of systemic lupus erythematosus.

Background: Neutropenia is more common in patients with systemic lupus erythematosus (SLE) and is a major cause of life-threatening infections. The increased apoptosis of neutrophils is likely to be an essential cause of neutropenia in SLE. However, the detailed mechanisms of increased neutrophil apoptosis in SLE remain unknown.

Case report: A novel nonsense mutation in the gene causes nonsyndromic hearing loss in a China family.

The gene is located on chromosome 5q13.2 and is associated with autosomal recessive nonsyndromic hearing loss (OMIM: # 610572). In this study, we identified and reported a novel nonsense mutation in c.

The diagnostic and prognostic value of heparin-binding protein in cerebrospinal fluid for patients with intracranial infections.

Background: This study aims to evaluate the diagnostic and prognostic value of heparin-binding protein (HBP) in cerebrospinal fluid (CSF) for patients with intracranial infections.

Methods: This study included 211 subjects, of whom 138 were diagnosed with intracranial infections, 20 were patients with non-infectious inflammatory encephalopathies, and 53 controls who were eventually excluded from intracranial infections and inflammatory encephalopathies. The levels of HBP and procalcitonin (PCT) in CSF were detected in the subjects, and the diagnostic value of CSF HBP and PCT for intracranial infections was assessed using the receiver operating characteristic (ROC) curves.

Preparation of PLA Nanoparticles and Study of Their Influencing Factors.

Nanoparticles (NPs) have attractive properties that have received impressive consideration in the last few decades. Polylactic acid nanoparticles (PLA-NPs) stand out as a biodegradable polyester with excellent biocompatibility. This investigation introduces PLA-NPs prepared by using the emulsification-solvent volatilization (O/W) method.

Enhancing image reconstruction in photoacoustic imaging using spatial coherence mean-to-standard-deviation factor beamforming.

In photoacoustic imaging (PAI), a delay-and-sum (DAS) beamforming reconstruction algorithm is widely used due to its ease of implementation and fast execution. However, it is plagued by issues such as high sidelobe artifacts and low contrast, that significantly hinder the ability to differentiate various structures in the reconstructed images. In this study, we propose an adaptive weighting factor called spatial coherence mean-to-standard deviation factor (scMSF) in DAS, which is extended into the spatial frequency domain.

Analysis of risk factor for peritonitis in peritoneal dialysis patients.

Objective: To investigate the risk factors for peritonitis in peritoneal dialysis patients and to develop and validate a predictive model.

Methods: A total of 219 patients undergoing continuous ambulatory peritoneal dialysis (CAPD) who had their first peritoneal dialysis catheter placement and regular follow-up at Wuhan No. 1 Hospital between April 2020 and August 2023 were included in this study.

Downregulated YTHDF2 expression in systemic lupus erythematosus is associated with inflammatory and neutrophil cytokine production.

Objectives: An increasing body of evidence suggests that N6-methyladenosine (m6A) plays a crucial role in the etiology of SLE. We focused on YTHDF2 expression in neutrophils and the relationship between YTHDF2 and the pathogenesis of SLE.

Methods: Sixty-one patients with SLE and 48 healthy controls (HC) were recruited, and their clinical characteristics were recorded.

Increased expression of epithelial-mesenchymal transition markers associated with recurrence of sinonasal inverted papilloma.

Sinonasal inverted papilloma (SNIP) is a benign epithelial proliferative disease with a high recurrence rate. The role of epithelial-mesenchymal transition (EMT) in the pathogenesis of SNIP remains unclear. EMT marker expression is elevated in SNIP tissues and is associated with its recurrence.

Dissecting the pathogenic effects of smoking in blood DNA methylation on allergic diseases.

Background: Allergic diseases, such as asthma and allergic rhinitis, present significant health challenges globally. Elucidating the genetic and epigenetic foundations is crucial for developing effective interventions.

Methods: We performed two-sample Mendelian Randomization (MR) analyses to investigate the associations between smoking behaviors and various allergic diseases, leveraging data from the FinnGen database.

Design and evaluation of collagenase-loaded nanoparticles for mechanical intervention of orthotopic hepatocellular carcinoma in rat model.

Altered tissue mechanics is vital for cancer development and malignancy, whether targeting the mechanical microenvironment could retard the initiation and progression of tumor is less explored. In this study, an orthotopic hepatocellular carcinoma (HCC) rat model was constructed to reproduce the mechanical and pathophysiological microenvironment of HCC development. LpMSN@CLG, a liver-targeted (L) and pH-sensitive (p) mesoporous silica nanoparticle (MSN) encapsulated with collagenase type-I (CLG), and DOX-LpMSN@CLG, on the basis of LpMSN@CLG, encapsulated with CLG and doxorubicin (DOX), were prepared to reduce matrix stiffness by degrading collagen in liver and HCC tumor.

Targeting autophagy: polydatin's role in inducing cell death in AML.

Acute myeloid leukemia (AML), a malignant disorder of the hematopoietic system, arises from leukemic stem cells (LSCs) and is the most prevalent form of blood cancer in adults. This study aimed to evaluate the therapeutic potential of polydatin (PD) in AML through and studies, respectively. This study was prompted by PD's novel role in enhancing tumor apoptosis and modulating autophagy.

Chromatin accessibility: biological functions, molecular mechanisms and therapeutic application.

The dynamic regulation of chromatin accessibility is one of the prominent characteristics of eukaryotic genome. The inaccessible regions are mainly located in heterochromatin, which is multilevel compressed and access restricted. The remaining accessible loci are generally located in the euchromatin, which have less nucleosome occupancy and higher regulatory activity.

Tumor energy metabolism: implications for therapeutic targets.

Tumor energy metabolism plays a crucial role in the occurrence, progression, and drug resistance of tumors. The study of tumor energy metabolism has gradually become an emerging field of tumor treatment. Recent studies have shown that epigenetic regulation is closely linked to tumor energy metabolism, influencing the metabolic remodeling and biological traits of tumor cells.

Composition and Morphological Characteristics of Extracellular Polymeric Substances of Different Tolerant Bacteria Under Perfluorobutanesulfonic Acid (PFBS) Stress.

This investigation studies the properties and composition of extracellular polymeric substances (EPS) of the four tolerant bacterial strains [NH (, TH, YH, and HE ()] under perfluorobutanesulfonic acid (PFBS) stress. The strains were acquired from athickened sludge in a fluorine chemical park. Each strain's EPS were isolated by heating and centrifugation, and their growth, metabolic activity, and EPS alteration research pre- and post-stress were assessed and compared.

Pyrotinib induces cell death in HER2-positive breast cancer via triggering HSP90-dependent HER2 degradation and ROS/HSF-1-dependent oxidative DNA damage.

HER2-positive breast cancer (HER2+ BC) is distinguished by its poor prognosis, propensity for early onset, and high risk of recurrence and metastasis. Consequently, anti-HER2-targeted therapy has emerged as a principal strategy in the treatment of this form of breast cancer. Pyrotinib, a novel irreversible pan-HER2 tyrosine kinase inhibitor, has brought fresh hope to patients with advanced HER2+ breast cancer.

Chromosome-level genome assembly of the mud carp (Cirrhinus molitorella) using PacBio HiFi and Hi-C sequencing.

The mud carp (Cirrhinus molitorella) is an important economic farmed fish, mainly distributed in South China and Southeast Asia due to its strong adaptability and high yield. Despite its economic importance, the paucity of genomic information has constrained detailed genetic research and breeding efforts. In this study, we utilized PacBio HiFi long-read sequencing and Hi-C technologies to generate a meticulously assembled chromosome-level genome of the mud carp.

Gratitude and Subjective Well-Being in Older Chinese Adults in Nursing Homes: The Mediating Roles of Self-Efficacy and Social Support.

Aim: With an aging global population, there has been a growing interest in the subjective well-being (SWB) of older people. As a positive emotion, gratitude has been found to be significantly and positively associated with SWB. However, the mechanisms underlying the relationship between gratitude and SWB remain poorly understood.

Rotating culture regulates the formation of HepaRG-derived liver organoids via YAP translocation.

Background: Liver organoid serves as an alternative model for liver pathophysiology in carbohydrate or lipid metabolism and xenobiotic metabolism transformation. Biomechanical cues including spaceflight mission can affect liver organoid construction and their related functions, but their underlying mechanisms are not fully understood yet. Here, a rotating cell culture device, namely Rotating Flat Chamber (RFC), was specifically designed for adhering cells or cell aggregated to elucidate the effects of altered gravity vector on HepaRG-derived liver organoids construction.

Ferroptosis: A key regulator and potential target for tissue injury.

The maintenance of iron homeostasis is essential for proper body function. A growing body of evidence suggests that iron imbalance is the common denominator in many tissue injuries, including acute, chronic, and reperfusion injuries. Ferroptosis, a novel form of programmed cell death due to metabolic abnormalities, has become increasingly recognized as an important process mediating the pathogenesis and progression of numerous tissue injuries, including cerebral, myocardial, lung, liver, kidney, and intestinal injuries.

Benth. Extract Ameliorates Hyperlipidemia in High-Fat Diet-Fed Mice and Rats by Regulating the Gut Microbiota.

Benth. (or () A. J.

Exploring the mechanism of Suxin Hugan Fang in treating ulcerative colitis based on network pharmacology.

As a traditional Chinese medicine formula used in clinical practice for an extended period, Suxin-Hugan-Fang (SXHGF) exhibits excellent anti-inflammatory properties. However, the efficacy of SXHGF in treating ulcerative colitis (UC) and its mechanism of action are still unclear. In this study, the therapeutic effects of SXHGF on UC were evaluated using network pharmacology and experimental validation, while also investigating its mechanism of action.

The Expression Levels of Transforming Growth Factor β1 and Tumor Necrosis Factor Receptor Associated Factor 6 in Allergic Rhinitis Patients and Their Potential Relationship with Epithelial - Mesenchymal Transition: A Pilot Prospective Observational Study.

Objective: To study the role of transforming growth factor beta 1 (TGF-β1) and tumor necrosis factor receptor related factor 6 (TRAF6) in the progression of epithelial mesenchymal transformation (EMT) in allergic rhinitis (AR).

Methods: A total of 30 patients underwent nasal endoscopic surgery at our Hospital were selected for 15 patients in each group based on their allergy status. Inferior turbinate mucosa tissue was obtained and analyzed using immunohistochemical (IHC) tests, real-time quantitative PCR (qRT-PCR) detection, and Western blotting (WB) tests to measure TGF-β1, TRAF6, E-cadherin, Vimentin, and α-Smooth Muscle Actin (α-SMA) expression levels.

Effects of pyrolysis temperatures on the structural properties of straw biochar and its adsorption of tris-(1-chloro-2-propyl) phosphate.

To investigate the effect of pyrolysis temperature on the adsorption behavior of the emerging organic pollutant tris-(1-chloro-2-propyl) phosphate (TCIPP) on biochar, corn stover was used as raw materials to prepare biochars at different pyrolysis temperatures (250, 350, 500, 700 °C) through limited oxygen carbonization. Elemental analysis, Boehm titration, FTIR, XPS, and other analytical methods were used to reveal the effect of pyrolysis temperature on the physicochemical properties of biochar and its mechanism of TCIPP adsorption. The results showed that the pyrolysis temperature had a significant impact on the physicochemical properties of biochar.