rs11614913 C Allele is Associated with Increased Wilms Tumor Susceptibility in Chinese Children.

Wilms tumor, also known as nephroblastoma, is the most common kidney cancer in children. The rs11614913 T>C polymorphism has been identified as a susceptibility locus in various adult cancers. However, it is unclear whether this polymorphism also increases the risk of pediatric cancer.

, a R2R3-MYB transcription factor from purple tea (), positively regulates anthocyanin biosynthesis.

In tea (), anthocyanins are important secondary metabolites that are linked to leaf color. Anthocyanin biosynthesis is a complex biological process, in which multiple genes including structural and regulatory genes are involved. Here, we describe the cloning and characterizing of a new R2R3-MYB transcription factor gene, , isolated from purple tea variety ''.

Talaromyces marneffei central nervous system infection unveiled by the novel Mp1p antigen detection assay in AIDS patient.

Background: In acquired immunodeficiency syndrome patients, Talaromyces marneffei infections are mostly disseminated and may involve the skin, mucosa, respiratory system, digestive system, lymphatic system, and as some reports indicate, the nervous system. Mp1p, a cell wall-specific polysaccharide in Talaromyces marneffei, is used for laboratory diagnosis of Talaromyces marneffei in blood and urine samples. However, Cerebrospinal fluid Mp1p diagnosis of Talaromyces marneffei central nervous system infection has not been reported.

Hidden Spread of Rare Serovars Isolated from Healthy Individuals - Yulin City, Guangxi Zhuang Autonomous Region, China, 2013-2022.

What Is Already Known About This Topic?: The emergence of rare multidrug-resistant serovars is increasingly common in developing countries, posing a significant public health risk.

What Is Added By This Report?: This report identified five rare serovars in China for the first time and using whole-genome sequencing, identified their hidden spread among healthy individuals. Additionally, antibiotic resistance genes and virulence genes were identified.

Bidirectional high-speed optical wireless communication with tunable large field of view assisted by liquid crystal metadevice.

Beam-steered infrared (IR) light communication has gained tremendous attention as one of the solutions of congested wireless communication traffic. High performance active beam-steering devices play a crucial role in data allocation and exchange. Conventional beam-steering devices such as spatial light modulator (SLM) and micro-electrical mechanical system (MEMS) mirror and the current emerging nonmechanical beam-steering metasurface-based devices are challenging to realize a large tunable steering angle beyond several degrees, which significantly hinders the spatial application of optical wireless communications (OWC).

Carried by a Transferable Plasmid in a Strain Isolated from Healthy Individuals.

Objective: Our study aimed to conduct genomic characterization of strains carrying the gene in the intestinal tract of healthy individuals. The objectives were to underscore the importance of genomic surveillance for drug resistance in both commensal and pathogenic bacteria among healthy populations, and to establish protocols for regulating drug resistance plasmids based on the completion of a comprehensive map of drug resistance plasmid genomes.

Methods: We performed antimicrobial susceptibility testing and employed second- and third-generation sequencing techniques to analyze strains harboring the gene, to surveil drug-resistant bacteria in the intestines of healthy subjects.

Capturing intermediates and membrane remodeling in class III viral fusion.

Enveloped viruses enter cells by fusing their envelopes to host cell membranes. Vesicular stomatitis virus (VSV) glycoprotein (G) is a prototype for class III fusion proteins. Although structures of the stable pre- and postfusion ectodomain of G are known, its fusogenic intermediates are insufficiently characterized.

Visual comfort models based on coloured text and neutral background combinations.

Reading on mobile phones can cause visual discomfort, negatively affecting visual health. Most studies have focused on neutral text-background combinations, with limited validation for coloured text-background combinations. This study investigates the impact of coloured text on neutral backgrounds and the colour difference between text and background on visual comfort during digital reading.

Net 30-Tb/s bidirectional IM/DD optical interconnect over 19-core fiber enabled by WDM uplink/downlink twin-SSB PAM-4 transmission.

High-capacity optical interconnects with short reach are hugely demanded driven by the exponential growth of data traffic. In this work, four-channel wavelength division multiplexing (WDM) uplink/downlink twin single-sideband (twin-SSB) signals are implemented by a wavelength selective switch (WSS) at once, which simplifies the structure of multi-channel SSB transmitters and reduces the cost of high-capacity optical interconnect. Compared to a double sideband scheme, it has been experimentally proven that the performance of SSB transmission over standard single-mode fiber (SSMF) at C-band with an ultra-high baud rate has been greatly improved, which has the ability to effectively overcome the power fading induced by chromatic dispersion in an intensity modulation and direct detection (IM/DD) system.

High carriage and possible hidden spread of multidrug-resistant Salmonella among asymptomatic workers in Yulin, China.

Food workers have frequent contact with unprocessed foods, but their carriage of Salmonella and potential influence on public health have not been comprehensively assessed. We investigated Salmonella carriage among food workers compared with non-food workers based on occupational health screening of 260,315 asymptomatic workers over an 8-year surveillance period in Yulin, China. We confirmed that healthy carriers serve as natural reservoirs for Salmonella, with higher carriage rates in food workers than non-food workers.

Individual differences in color matches and cone spectral sensitivities in 51 young adults.

Forty-six young adult observers with normal color vision (plus five from an earlier study) made a series of color matches using a new LED-based, multi-wavelength visual trichromator. Thirteen LED lights of different wavelengths were combined to produce 11 triplets of lights that observers were asked to match to a white reference light of 7500 K over visual angles of either 2° or 10°. Matches were initially made by asking observers to adjust the intensities of the three lights making up each triplet.

Generic color correction for tone mapping operators in high dynamic range imaging.

One of the significant challenges in tone mapping is to preserve the perceptual quality of the tone-mapped images. Traditional tone mapping operators (TMOs) compress the luminance of high dynamic range (HDR) images with little to no consideration of image color information resulting into suboptimal colors. Existing color management algorithms require either manual parameter tuning or introducing lightness and hue shifts.

Adaptive block-matching and 4D denoising scheme for a distributed vibration sensing system.

A noise reduction method based on the block-matching and 4D (BM4D) scheme is proposed to improve the signal-to-noise ratio (SNR) in distributed vibration sensing (DVS) systems. In the proposed scheme, the original Rayleigh backscattering (RBS) signal is converted into a three-dimensional image containing Rayleigh trajectory and energy information. The correlation between the time-domain and spatial-domain signals is then used to achieve the denoising operation.

Effective treatment with intravenous immunoglobulin for Henoch-Schönlein purpura with refractory gastrointestinal symptoms in an adolescent: A CARE-compliant case report.

Rationale: This article presents a complex case of refractory Henoch-Schönlein purpura (HSP), initially manifesting with complex gastrointestinal (GI) symptoms, and discusses diagnostic and therapeutic challenges encountered. It aims to enhance understanding of the disease and provide evidence for the potential efficacy of intravenous immunoglobulin (IVIG) treatment in this condition.

Patient Concerns: A 16-year-old male patient presented with persistent abdominal pain, nausea, vomiting, and constipation for 8 days, leading to hospital admission.

Goal-directed Perfusion to Reduce Acute Kidney Injury After Pediatric Cardiac Operation.

Background: Although goal-directed perfusion (GDP) during cardiopulmonary bypass (CPB) has been discussed extensively in adult studies, no pediatric indexed oxygen delivery (Doi) thresholds are universally accepted, and no pediatric randomized controlled trial has been reported. This study aimed to determine whether the GDP initiative (maintaining Doi ≥360 mL/min/m during CPB) could reduce the incidence of acute kidney injury (AKI) after pediatric cardiac operation and improve clinical outcomes.

Methods: This single-center randomized controlled trial enrolled 312 pediatric patients, who were randomized to receive either the GDP strategy or a conventional perfusion strategy during CPB.

SEC14L3 knockdown inhibited clear cell renal cell carcinoma proliferation, metastasis and sunitinib resistance through an SEC14L3/RPS3/NFκB positive feedback loop.

Background: Clear cell renal cell carcinoma (ccRCC) arises from the renal parenchymal epithelium and is the predominant malignant entity of renal cancer, exhibiting increasing incidence and mortality rates over time. SEC14-like 3 (SEC14L3) has emerged as a compelling target for cancer intervention; nevertheless, the precise clinical implications and molecular underpinnings of SEC14L3 in ccRCC remain elusive.

Methods: By leveraging clinical data and data from the TCGA-ccRCC and GEO datasets, we investigated the association between SEC14L3 expression levels and overall survival rates in ccRCC patients.

Enhancing the Efficacy of Breast Cancer Immunotherapy Using a Smac-Armed Oncolytic Virus.

It has been shown that the response rate of TNBC is dependent on the level of PD-L1 and the tumor microenvironment (TME). Approaches that alter the TME can improve the efficacy of ICIs. : We have engineered a Smac-armed oncolytic virus by inserting a Smac transgene into the genome of a vesicular stomatitis virus to generate VSV-S.

Implementation of the Observational Medical Outcomes Partnership Model in Electronic Medical Record Systems: Evaluation Study Using Factor Analysis and Decision-Making Trial and Evaluation Laboratory-Best-Worst Methods.

Background: Electronic medical record (EMR) systems are essential in health care for collecting and storing patient medical data. They provide critical information to doctors and caregivers, facilitating improved decision-making and patient care. Despite their significance, optimizing EMR systems is crucial for enhancing health care quality.

Architectural organization and fusion protein structure of lymphocytic choriomeningitis virus.

Unlabelled: Arenaviruses exist globally and can cause hemorrhagic fever and neurological diseases, exemplified by the zoonotic pathogen lymphocytic choriomeningitis virus (LCMV). The structures of individual LCMV proteins or their fragments have been reported, but the architectural organization and the nucleocapsid assembly mechanism remain elusive. Importantly, the structure of the arenavirus fusion protein complex (glycoprotein complex, GPC) as present on the virion prior to fusion, particularly with its integral stable signal peptide (SSP), has not been shown, hindering efforts such as structure-based vaccine design.

Conditional survival and changing risk profile in patients with gliosarcoma.

Background: Conditional survival (CS) considers the duration since the initial diagnosis and can provide supplementary informative insights. Our objective was to evaluate CS among gliosarcoma (GSM) patients and develop a CS-incorporated nomogram to predict the conditional probability of survival.

Methods: This retrospective study using the Surveillance, Epidemiology, and End Results (SEER) database included patients with GSM between 2000 and 2017.

Bidirectional TFDM 200 G coherent PON with a simplified receiver at the ONU side.

Time and frequency division multiplexing (TFDM) coherent passive optical networks (PONs) are considered as a promising candidate for future optical access networks due to the advantage of high sensitivity, high spectral efficiency, and flexibility. We propose a novel, to our knowledge, bidirectional TFDM 200-Gb/s coherent PON architecture based on the digital subcarrier multiplexing (DSCM) technology. A polarization-insensitive simplified coherent receiver is achieved at the ONU side by Alamouti coding and heterodyne detection.