Near-infrared fluorescent probe for visualization of nitroxyl in the plant response to stress.

Background: Nitroxyl (HNO) is an emerging signaling molecule that plays a significant regulatory role in various aspects of plant biology, including stress responses and developmental processes. However, understanding the precise actions of HNO in plants has been challenging due to the absence of highly sensitive and real-time in situ monitoring tools. Consequently, it is crucial to develop effective and accurate detection methods for HNO.

Mapping the current status and outlook of research on noonan syndrome over the last 26 years: a bibliometric and visual analysis.

Background: Noonan syndrome (NS) is a rare group of autosomal genetic disorders. In recent years, with the exploration and development of molecular diagnostic techniques, more and more researchers have begun to pay attention to NS. However, there is still a lack of reports on the bibliometric analysis of NS worldwide.

Impact of policy reforms on hospital-at-home services: an interrupted time series analysis of Shanghai.

Background: The global rise in elderly populations and chronic disease patients has increased the demand for hospital-at-home (HaH) services, which could help reduce hospitalization costs.

Objective: To assess the impact of two policies on the implementation of HaH services in Shanghai.

Methods: A two-stage interrupted time series (ITS) analysis with a control group was conducted to examine changes in three areas-institutional capacity, home-based medical services, and HaH beds-using 11 indicators from 2007 to -2022 across all community health service centres and hospitals providing HaH services.

FAPs orchestrate homeostasis of muscle physiology and pathophysiology.

As a common clinical manifestation, muscle weakness is prevalent in people with mobility disorders. Further studies of muscle weakness have found that patients with muscle weakness present with persistent muscle inflammation, loss of muscle fibers, fat infiltration, and interstitial fibrosis. Therefore, we propose the concept of muscle microenvironment homeostasis, which explains the abnormal pathological changes in muscles through the imbalance of muscle microenvironment homeostasis.

The Effects of Mindfulness on Shame: Exploring Mediation by Cognitive Flexibility and Self-Compassion in a Chinese Adult Population.

To examine the effects of mindfulness on shame and the mechanisms mediated by cognitive flexibility and self-compassion in a Chinese adult population in daily life, we conducted two studies. Study 1 was a cross-sectional study using the Five-Factor Mindfulness Questionnaire, the Cognitive Flexibility Inventory, the Self-Compassion Scale, and the Self-Conscious Affect-3, which were administered to 481 adults in Beijing and Chengdu. For Study 2, an 8-month follow-up study was conducted on 128 of the adults.

Alterations of gut virome with close interaction in the progression of estrogen deficiency-induced osteoporosis.

Previous research has established a link between gut microbiota and osteoporosis (OP) advancement. However, there remains a limited understanding of the crucial contribution of the gut virome in the onset and progression of OP. We employed metagenomic shotgun sequencing and gut virome sequencing to process the ovariectomy (OVX)-induced OP murine model, which revealed significant disparities in bacteriome and virome compositions between subjects with OP and healthy controls.

Erratum: Burden of disease attributable to high body mass index: an analysis of data from the Global Burden of Disease Study 2021.

[This corrects the article DOI: 10.1016/j.eclinm.

Phosphorylation determines the glucose metabolism reprogramming and tumor-promoting activity of sine oculis homeobox 1.

Aerobic glycolysis is a hallmark of cancer and is regulated by growth factors, protein kinases and transcription factors. However, it remains poorly understood how these components interact to regulate aerobic glycolysis coordinately. Here, we show that sine oculis homeobox 1 (SIX1) phosphorylation integrates growth factors (e.

Exposure to multiple metals and leukocyte telomere length in children and adolescents: The mediating effect of thyroid hormones.

Exposure to metals has been related to alterations in leukocyte telomere length (LTL), an aging marker. However, the evidence regarding this relationship in children and adolescents, as well as the underlying mechanisms, remains unclear. Therefore, we aimed to explore the individual and mixture effects of metals on LTL in children and adolescents and to assess the mediating role of thyroid hormones and the modifying effect of a healthy lifestyle.

Dissolution and solubility of the calcium-nickel carbonate solid solutions [(CaNi)CO] at 25 °C.

A series of the calcium-nickel carbonate solid solutions [(CaNi)CO] were synthesized and their dissolution in N-degassed water (NDW) and CO-saturated water (CSW) at 25 °C was experimentally investigated. During dissolution of the synthetic solids (Ni-bearing calcite, amorphous Ca-bearing NiCO and their mixtures), the Ni-calcite and the Ca-NiCO dissolved first followed by the formation of the Ni-bearing aragonite-structure phases. After 240-300 days of dissolution in NDW, the water solutions achieved the stable Ca and Ni concentrations of 0.

Global burden of disease attributable to metabolic risk factors in adolescents and young adults aged 15-39, 1990-2021.

Background: Metabolic risk factors are a significant cause of global burden among adolescents and young adults, but there is a lack of attention to the burden attributable to these metabolic risk factors globally.

Aims: This study aims to provide comprehensive estimates of five important metabolic risk factors and the attributable disease burden in people aged 15-39 years from 1990 to 2021, based on the Global Burden of Disease Study (GBD) database.

Methods: Global total deaths and disability-adjusted life years (DALYs) were used to describe the burden attributable to five common metabolic risk factors, including high fasting plasma glucose (FPG), high low-density lipoprotein cholesterol (LDL-C), high systolic blood pressure (SBP), high body mass index (BMI), and kidney dysfunction, in adolescents and young adults.

Reproductive factors and biological aging: the association with all-cause and cause-specific premature mortality.

Study Question: Are reproductive factors associated with biological aging, and does biological aging mediate the associations of reproductive factors with premature mortality?

Summary Answer: Multiple reproductive factors are related to phenotypic age acceleration (PhenoAge-Accel), while adherence to a healthy lifestyle mitigates these harmful effects; PhenoAge-Accel mediated the associations between reproductive factors and premature mortality.

What Is Known Already: Accelerated aging is a key contributor to mortality, but knowledge about the effect of reproductive factors on aging is limited.

Study Design, Size, Duration: This prospective cohort study included 223 729 women aged 40-69 years from the UK biobank in 2006-2010 and followed up until 12 November 2021.

Difluorobenzene as an Antisolvent for Fluorinated Electrolyte to Achieve Unparalleled Cycle Life of Lithium Metal Battery.

Electrolytes play a crucial role in enhancing the cycling stability and overall lifespan of lithium metal batteries (LMBs). However, conventional electrolytes achieve ununiform and low ionic conductivity solid electrolyte interphase (SEI), leading to uncontrolled lithium dendrite growth and dead lithium formation, rendering them inadequate for meeting the performance of high energy density LMBs. Herein, a 1,2-difluorobenzene (1,2-dFBn) is introduced as antisolvent in fluorinated electrolyte which is composed of fluoroethylene carbonate (FEC) and lithium bis(trifluoromethanesulfonyl)imide (LiTFSI).

A switch from lysosomal degradation to secretory autophagy initiates osteogenic bone metastasis in prostate cancer.

The identification of both autophagy-related material degradation and unconventional secretion has paved the way for significant breakthroughs linking autophagy to a plethora of physiological processes and disease conditions. However, the mechanisms that coordinate these two pathways remain elusive. Here, we demonstrate that a switch from the lysosomal degradation to a secretory autophagy pathway is governed by protein tyrosine phosphatase 1B (PTP1B, encoded by PTPN1).

Psychometric validation and refinement of the Chinese Interoceptive Accuracy Scale (IAS) in general population and patients with chronic pain.

Objective: Interoception plays an important role in psychological functioning and mental and physical health. Recent studies have highlighted the need to distinguish between different aspects of interoception in self-report measures, including subjective interoceptive accuracy and attention. However, there is currently no questionnaire available in Chinese to measure either of these aspects, especially in patients with chronic pain conditions.

ANGPTL3 as a target for treating lipid disorders in type 2 diabetes patients.

Type 2 diabetes mellitus (T2DM) is a globally prevalent metabolic disorder, and cardiovascular disease (CVD) is a significant cause of mortality and morbidity in diabetic individuals. In addition to hyperglycemia, lipid abnormalities associated with T2DM play a crucial role in the development of CVD complications. Diabetic dyslipidemia is characterized by elevated levels of triglyceride (TG)-rich lipoproteins and small dense low-density lipoprotein (LDL) particles, reduced high-density lipoprotein (HDL) cholesterol, and impaired HDL function.

Transcription Factor CmWRKY13 Regulates Cucurbitacin B Biosynthesis Leading to Bitterness in Oriental Melon Fruit ().

Bitterness, caused by cucurbitacin B (CuB), is one of the important traits that affects melon fruit quality and consumer acceptance. Therefore, the detailed mechanism behind the regulation of CuB biosynthesis on melon fruit needs to be further explored. This study investigated CuB content and transcriptomes of "YMR" melon fruit treated by 5 and 20 mg L CPPU.

Optimizing the combination of chemotherapeutic drugs along with radiotherapy for extranodal NK/T-cell lymphoma.

Background: Extranodal natural killer/T-cell lymphoma (ENKTCL) has a unique treatment principle. However, the optimal combination of drugs along with radiotherapy (RT) is unknown.

Design: Retrospective cohort study.

[Recharge Sources and Hydrochemical Evolution Mechanism of Surface Water and Groundwater in Typical Karst Mining Area].

To study the recharge source, hydrochemical characteristics, and evolution process of karst underground water and surface water in the Xianghualing Mining area, we collected 32 groups of samples from karst underground water and surface water sources in and around the mining area. Based on multivariate statistical analysis, the Piper three-line diagram, Gibbs diagram, and ion ratio coefficient, this study analyzed the hydrogeochemical characteristics of karst underground water and surface water in the Xianghualing Mining area. The study systematically revealed the recharge source, recharge age, and hydrochemical evolution law of both water sources.