UGCG promotes chemoresistance and breast cancer progression via NF-κB and Wnt/β-catenin pathway activation.

Background: Taxane-based chemotherapy is the primary treatment for triple-negative breast cancer (TNBC), yet clinical outcomes remain unsatisfactory due to the persistence of chemoresistance. Identifying key factors that contribute to chemoresistance and understanding the associated molecular mechanisms is therefore essential.

Method: The GEO databases were utilized to pinpoint factors related to chemoresistance, which were subsequently validated using clinical tissue samples.

Early onset pancreatic cancer: A review.

Early-onset pancreatic cancer (EOPC) is usually defined as patients with pancreatic cancer before the age of 50 years, which is relatively rare. However, the research on EOPC is somewhat obscure, and the specific clinical and molecular characteristics of this condition are debated. In this review, we discussed the differences between EOPC and late-onset pancreatic cancer (LOPC) or average-onset pancreatic cancer (AOPC) with a focus on clinical and molecular characteristics, survival outcomes and treatment to promote the diagnosis and treatment of EOPC.

A longitudinal study of resilience and social function in patients with colorectal cancer and stomas.

Objective: To explore the dynamic changes, influencing factors, and relationships between resilience and social function in patients with colorectal cancer (CRC) and stomas at different postoperative stages, and to inform precise psychosocial rehabilitation interventions.

Methods: A longitudinal study was conducted at a tertiary hospital in eastern China from January 2021 to June 2023. Patients completed a self-designed socio-demographic questionnaire one month post-surgery, and the Connor and Davidson Resilience Scale (CD-RISC) and Social Dysfunction Screening Scale (SDSS) at 1, 3, and 5 months post-surgery.

Comparative Genomic Analysis of an Strain Isolated from a Patient with Urinary Tract Infection.

Opportunistic infections caused by fungi, particularly those occurring in immunocompromised patients, are considered challenging worldwide. Therefore, a comprehensive understanding of pathogenic fungi is necessary. The present study reports the isolation of a strain of , which is difficult to detect using conventional clinical assays, from the sterile urine samples of a patient with a urinary tract infection.

Focal segmental glomerulosclerosis and neurogenic bladder in a Chinese patient with a novel pathogenic variation in TRIM8 gene: A case report.

To report a novel variation in the TRIM8 gene in a Chinese patient who developed focal segmental glomerulosclerosis (FSGS) and neurogenic bladder. Retrospective analysis of the clinical manifestations, laboratory results, renal biopsy results, and genetic data of the patient with FSGS complicated with neurogenic bladder. The patient was a 6-year and 8-month-old Chinese Zang ethnic boy with low-set ears, widely-spaced eyes (inner canthal distance exceeds the 95th percentile of normal inner canthal distance), a small jaw, and a short neck.

Clonal hematopoiesis of indeterminate potential (CHIP): A potential contributor to lymphoma.

Clonal hematopoiesis (CH) typically refers to the clonal expansion of hematopoietic stem cells (HSCs) due to genetic mutations, serving as the pathogenic basis for various diseases. Clonal hematopoiesis of indeterminate potential (CHIP) is a subtype of CH, emerging as a significant risk factor for myeloid malignancies and cardiovascular diseases, which has attracted increasing attention. However, recent research has unveiled previously overlooked links between CHIP and lymphoma.

The role of acupuncture in treating premature ejaculation and its probable neurobiological mechanism.

Background: Premature ejaculation (PE) is one of the most common diseases in andrology and leads to serious male sexual dysfunction. Although several targeted oral drug therapies are used to treat PE, they often face challenges related to imprecise targeting and adverse effects. Acupuncture has shown potential in prolonging ejaculation time and improving couples' sexual quality of life.

Effect of Vitamin D Level on Female Vaginitis in Xi'an, China.

Background: Vaginitis is a common disease of the reproductive system in women, causing discomfort in daily life. Many reports indicate that the causes of vaginitis are related to vaginal microecological disturbances. Therefore, treatment strategies to restore microecological balance have shown promising results in both basic research and clinical settings.

Electrochemical synthesis of γ-carbolinones sulfonylation-triggered cyclization of indole-3-carboxamides.

A novel electrochemical radical cyclization reaction of -acryloyl-indole-3-carboxamides with sodium sulfinates as coupling partners has been developed, which delivers multi-substituted γ-carbolinones as products with up to 70% yields. This study represents the first example of the radical cyclization reaction of indole-3-carboxamides under electrochemical conditions. The reaction features a broad substrate scope of sodium sulfinates and indole-3-carboxamides, and provides a new and efficient strategy for the synthesis of γ-carbolinone derivatives.

Ultrafast structural dynamics of UV photoexcited ,-1,3-cyclooctadiene observed with time-resolved electron diffraction.

Conjugated diene molecules are highly reactive upon photoexcitation and can relax through multiple reaction channels that depend on the position of the double bonds and the degree of molecular rigidity. Understanding the photoinduced dynamics of these molecules is crucial for establishing general rules governing the relaxation and product formation. Here, we investigate the femtosecond time-resolved photoinduced excited-state structural dynamics of ,-1,3-cyclooctadiene, a large-flexible cyclic conjugated diene molecule, upon excitation with 200 nm using mega-electron-volt ultrafast electron diffraction and trajectory surface hopping dynamics simulations.

Predictive value of low serum interleukin-33 levels in acute ischemic stroke outcomes.

Background: Human interleukin-33 (IL-33), a member of the IL-1 family, has been identified as a therapeutic target due to its role as a proinflammatory mediator in various diseases. This study aims to evaluate the prognostic value of serum IL-33 levels in patients admitted with their first-ever acute ischemic stroke.

Methods: This single-center, prospective, observational study included 216 patients with acute ischemic stroke.

Circulating exosomal PCAT1 as a complement of carcinoembryonic antigen for early colorectal cancer diagnosis.

Backgrounds: Given the global prevalence of colorectal cancer (CRC), advancements in prompt and accurate diagnosis are crucial. Long non-coding RNAs (lncRNAs) in serum exosomes are emerging as potential diagnostic biomarkers. This study evaluated the feasibility of using serum exosomal lncRNAs for early-stage CRC diagnosis in clinical practice.

Abnormal eye movements: relationship with clinical symptoms and predictive value for Alzheimer's disease.

Background: Abnormal eye movements occur at the early stages of Alzheimer's disease (AD). However, the characteristics of abnormal eye movements of patients with AD and their relationship with clinical symptoms remain inconsistent, and their predictive value for diagnosing and monitoring the progression of AD remains unclear.

Methods: A total of 42 normal controls, 63 patients with mild cognitive impairment due to AD (AD-MCI), and 49 patients with dementia due to AD (AD-D) were recruited.

Co-creation and community engagement in implementation research with vulnerable populations: a co-creation process in China.

Background Top-down implementation strategies led by researchers often generate limited or tokenistic community engagement. Co-creation, a community engagement methodology, aims to create a shared leadership role of program beneficiaries in the development and implementation of programs, and encourages early and deep involvement of community members. We describe our experience using a four-stage co-creation approach to adapt and implement a sexually transmitted diseases (STD) testing intervention among men who have sex with men (MSM) in China.

Thermo-responsive circularly polarized luminescence from carbon quantum dots in a cellulose-based chiral nematic template.

Circularly polarized light emitting active materials are of great interest, and the convenient tuning of the circularly polarized luminescence (CPL) remains a significant challenge. Integrating fluorescent materials into chiral photonic crystals to achieve tunable CPL is a promising approach, allowing efficient manipulation of CPL by adjusting the photonic band gap (PBG). We combined carbon quantum dots (CQDs) with hydroxypropyl cellulose (HPC), which self-assembles into a cholesteric liquid crystal (CLC).

4'-Demethylpodophyllotoxin functions as a mechanism-driven therapy by targeting the PI3K-AKT pathway in Colorectal cancer.

The treatment of colorectal cancer (CRC) poses significant challenges in terms of drug resistance and poor prognosis, necessitating the exploration of effective therapeutic strategies. In this study, high-throughput drug screening was utilized to identify Chinese herbal medicines with notable therapeutic effects on CRC. Among the compounds identified, 4'-demethylpodophyllotoxin (DOP), a derivative of podophyllotoxin, emerged as a potent anti-cancer compound.

S1 Vertebral Bone Quality Score Independently Predicts Proximal Junctional Kyphosis After Posterior Hemivertebra Resection With Transpedicular Instrumentation.

Objective: Proximal junctional kyphosis (PJK) is a prevalent postoperative complication after posterior hemivertebra (HV) resection. Previous research has demonstrated a strong correlation between the development of PJK and reduced bone mineral density. The vertebral bone quality (VBQ) score, derived from magnetic resonance imaging, is considered a predictive and evaluative tool for bone mineral density.

Engineered Reactive Oxygen Species (ROS)-Responsive Artificial H/Cl Ion Channels for Targeted Cancer Treatment.

Reactive oxygen species (ROS)-responsive ion channels regulate the ion flow across the membranes in response to alterations in the cellular redox state, playing a crucial role in cellular adaptation to oxidative stress. Despite their significance, replicating ROS-responsive functionality in artificial ion channels remains elusive. In this study, we introduce a novel class of artificial H/Cl ion channels activatable by elevated ROS levels in cancer cells.

Hydroxysafflor yellow A, a natural food pigment, ameliorates atherosclerosis in ApoE mice by inhibiting the SphK1/S1P/S1PR3 pathway.

Atherosclerosis (AS) is the pathologic basis of many cardiovascular diseases (CVDs). Hydroxysafflor yellow A (HSYA) is a valuable natural food pigment that has been reported to have significant health-promoting abilities. However, the anti-AS efficacy and mechanisms of HSYA have not yet been characterized.

Molecular characterization of extended-spectrum β-lactamases from the Akkermansia genus.

Akkermansia muciniphila, a member of the Verrucomicrobiota phylum, is recognized as a key gut microbe and has emerged as a potential next-generation probiotic. Assessment of antibiotic resistance in probiotics is a prerequisite for their application, while very few is studied in Akkermansia species. To address this, eight representative class A β-lactamases (36.