Identification of active ingredients from Lamiophlomis rotata that increase wound repair in mouse skin.

Background And Purpose: We previously showed that the iridoid glycoside extract of Lamiophlomis rotata (IGLR) induces M2 macrophage polarisation to accelerate wound healing. The potentially active compounds (quality markers) in IGLR that accelerate wound healing have not been elucidated; we here identified quality markers that accelerate wound healing.

Experimental Approach: After IGLR gavage of dorsal excisional wound mice and normal mice for 7 days, the tissues were analysed using the matrix-assisted laser desorption/ionisation (MALDI) mass spectrometry imaging (MSI) method and were further validated by liquid chromatography/mass spectrometry (LC/MS) coupled with multivariate analyses to identify quality markers.

Key-Axis-based Localization of Symmetry Axes in 3D Objects Utilizing Geometry and Texture.

In pose estimation for objects with rotational symmetry, ambiguous poses may arise, and the symmetry axes of objects are crucial for eliminating such ambiguities. Currently, in pose estimation, reliance on manual settings of symmetry axes decreases the accuracy of pose estimation. To address this issue, this method proposes determining the orders of symmetry axes and angles between axes based on a given rotational symmetry type or polyhedron, reducing the need for manual settings of symmetry axes.

Reconstructing Historical Land Use and Anthropogenic Inputs in Lake Victoria Basin: Insights from PAH and n-Alkane Trends.

Over the past century, human activities have profoundly transformed global ecosystems. Lake Victoria in East Africa exemplifies these challenges, showcasing the interplay of anthropogenic pressures driven by land use changes, urbanization, agriculture, and industrialization. Our comprehensive study investigates polycyclic aromatic hydrocarbons (PAHs) and n-alkanes in the lake and its catchment to trace their sources and historical deposition.

The Use of Gut Organoids: To Study the Physiology and Disease of the Gut Microbiota.

The intestinal flora has attracted much attention in recent years. An imbalance in the intestinal flora can cause not only intestinal diseases but also cause a variety of parenteral diseases, such as endocrine diseases, nervous system diseases and cardiovascular diseases. Research on the mechanism of disease is likely to be hampered by sample accessibility, ethical issues, and differences between cellular animal and physiological studies.

Clinical value and role of long non-coding RNA PSMB8-AS1 in the progress of ischemic stroke in patients with hypertension.

Hypertension is a common risk factors for ischemic stroke (IS), with the widely involvement of long non-coding RNAs (lncRNAs). The expression pattern and clinical significance of lncRNA PSMB8-AS1 was examined in essential hypertension (EH) patients with or without IS, as well as its role and mechanism in IS-induced neuron cell injury. Serum PSMB8-AS1 levels in 260 EH cases without IS and 280 participants with IS were detected via reverse transcription - quantitative polymerase chain reaction (RT-qPCR).

Testing the memory encoding cost theory using the multiple cues paradigm.

Recent developments have introduced the Memory Encoding Cost (MEC) theory to explain the role of attention in exogenous spatial cueing effects. According to this theory, the cost effect (when comparing invalid to neutral cues) arises from attentional suppression resulting from memory encoding of the cue. Conversely, the benefit effect (when comparing valid to neutral cues) is thought to result from a combination of attentional facilitation caused by the cue and encoding-related attentional suppression.

Mast cells: key players in digestive system tumors and their interactions with immune cells.

Mast cells (MCs) are critical components of both innate and adaptive immune processes. They play a significant role in protecting human health and in the pathophysiology of various illnesses, including allergies, cardiovascular diseases and autoimmune diseases. Recent studies in tumor-related research have demonstrated that mast cells exert a substantial influence on tumor cell behavior and the tumor microenvironment, exhibiting both pro- and anti-tumor effects.

Copper-Catalyzed Intermolecular [2 + 2 + 2] Annulation of Diynes with Alkynes: Construction of Carbazoles.

Transition-metal-catalyzed [2 + 2 + 2] annulation of alkynes is an efficient pathway for the synthesis of aromatic compounds. However, most of the established methods require noble metal catalysts. Herein, we report a copper-catalyzed intermolecular [2 + 2 + 2] annulation of diynes with alkynes through vinyl cation intermediates, enabling the atom-economical preparation of biologically important carbazole skeletons.

Potential Involvement of (Enterobacteriales, Enterobacteriaceae) in Biotype Differentiation of (Hemiptera: Aphididae).

, an obligate endosymbiont of most aphid species, can influence aphids' host adaptability through amino acid metabolism, potentially mediating biotype differentiation. However, its role in the biotype differentiation of remains unclear. To address this issue, six biotypes were tested in this study.

Epstein-Barr Virus BRRF1 Induces Butyrophilin 2A1 in Nasopharyngeal Carcinoma NPC43 Cells via the IL-22/JAK3-STAT3 Pathway.

Epstein-Barr virus is highly associated with nasopharyngeal carcinoma (NPC) with genes expressed for tumor transformation or maintenance of viral latency, but there are certain genes that can modulate immune molecules. Butyrophilin 2A1 (BTN2A1) is an important activating protein for presenting phosphoantigens for recognition by Vγ9Vδ2 T cells to achieve antitumor activities. We have previously shown that Vγ9Vδ2 T cells achieve efficacy against NPC when BTN2A1 and BTN3A1 are upregulated by stimulating EBV gene expression, particularly LMP1.

Nonenhancing Margin and Pial Invasion in Magnetic Resonance Imaging can Predict Isocitrate Dehydrogenase Status in Glioma Patients.

Background: The presence of isocitrate dehydrogenase (IDH) mutations and 1p/19q codeletion significantly influences the diagnosis and prognosis of patients with lower-grade gliomas (LGGs). The ability to predict these molecular signatures preoperatively can inform surgical strategies. This study sought to establish an interpretable imaging feature set for predicting molecular signatures and overall survival in LGGs.

Bone health management in endocrine-treated patients with prostate cancer: a summary of evidence.

Objective: This study aimed to gather and assess the most reliable evidence on bone health management in patients undergoing endocrine therapy for prostate cancer, with the goal of informing clinical practice.

Design And Methods: Utilizing the '6S' evidence model, a comprehensive literature search was conducted across various sources such as computerized decision support systems, national and international guideline networks, society websites, and databases encompassing clinical decision-making, guidelines, systematic reviews, evidence summaries, and expert consensus. The search spanned from April 2014 to April 2024, with two researchers independently evaluating the quality of the identified literature.

Cyanobacteria in late lag and exponential phases suit different pre-chlorination and coagulation strategies.

Pre-chlorination is usually applied to facilitate coagulation process when treating cyanobacteria-laden source waters. However, the responses of cyanobacteria after chlorination were varied in different growth phases, hence how these differences affect the coagulation is not clear. In this study, Microcystis aeruginosa (M.

Acid Catalysis Mediated by Aqueous Hydronium Ions Formed by Contacting Zeolite Crystals with Liquid Water.

Zeolites are crystalline microporous aluminosilicates widely used as solid acids in catalytic routes to clean and sustainable energy carriers and chemicals from biogenic and fossil feedstocks. This study addresses how zeolites act as weak polyprotic acids and dissociate to form extra-crystalline hydronium (HO) ions in liquid water. The extent of their dissociation depends on the energy required to form the conjugate framework anions, which becomes unfavorable as the extent of dissociation increases intracrystalline charge densities because repulsive interactions ultimately preclude the detachment of all protons as catalytically relevant HO(aq) ions.

Novel candidate plasma proteins for the pathogenesis and treatment of atopic dermatitis revealed by proteome-wide association study.

Atopic dermatitis (AD) is an immune-related skin disease with a genetic background. Numerous loci have been identified associated with AD to better comprehend its complicated genetic mechanisms by genome‑wide association studies (GWASs). However, current studies reveal the underlying mechanisms of these loci in the pathogenesis of AD inadequately.

Challenges and strategies toward oncolytic virotherapy for leptomeningeal metastasis.

Meningeal metastasis (LM) is commonly seen in the advanced stages of cancer patients, often leading to a rapid decline in survival time and quality of life. Currently, there is still a lack of standardized treatments. Oncolytic viruses (OVs) are a class of emerging cancer therapeutics with the advantages of selectively replicating in cancer cells, delivering various eukaryotic transgenes, inducing immunogenic cell death, and promoting anti-tumor immunity.

Resistance monitoring of diamide insecticides and characterization of field-evolved chlorantraniliprole resistance among Chinese populations of the tomato pinworm Phthorimaea (=Tuta) absoluta (Lepidoptera: Gelechiidae).

The tomato pinworm, Phthorimaea (=Tuta) absoluta, is considered one of the most destructive and invasive insect pests worldwide, having developed significant resistance to many popular insecticides. In this study, we monitored the field resistance of P. absoluta populations from China to three diamide insecticides: flubendiamide, chlorantraniliprole, and cyantraniliprole.

Risk of COVID-19 infection in patients with NSCLC receiving EGFR-TKI targeted therapy during the first wave in China.

Objective: We examined the factors influencing hospitalization and prognosis among patients with non-small cell lung cancer receiving epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) targeted therapy during the first wave of the coronavirus disease 2019 (COVID-19) pandemic.

Methods: In total, 267 patients diagnosed with NSCLC who were receiving treatment with third-generation EGFR-TKIs were included in our retrospective study. Data on patients' demographics, clinical characteristics, and survival were collected and analyzed.

A Novel Homozygous Missense ZP1 Variant Result in Human Female Empty Follicle Syndrome.

Empty follicle syndrome (EFS) is a disorder characterised by the unsuccessful retrieval of oocytes from matured follicles following ovarian stimulation for in vitro fertilisation (IVF). Genetic factors significantly contribute to this pathology. To date, an increasing number of genetic mutations associated with GEFS have been documented, however, some cases still remain unexplained by these previously reported mutations.

A clinically feasible algorithm for the parallel detection of glioma-associated copy number variation markers based on shallow whole genome sequencing.

Molecular features are incorporated into the integrated diagnostic system for adult diffuse gliomas. Of these, copy number variation (CNV) markers, including both arm-level (1p/19q codeletion, +7/-10 signature) and gene-level (EGFR gene amplification, CDKN2A/B homozygous deletion) changes, have revolutionized the diagnostic paradigm by updating the subtyping and grading schemes. Shallow whole genome sequencing (sWGS) has been widely used for CNV detection due to its cost-effectiveness and versatility.