Designing fluorescent covalent organic frameworks through regulation of link bond for selective detection of Al and Ce.

The high thermal stability and chemical durability of amide-linked covalent organic frameworks (amide COFs) make them a promising material for a range of new applications. Nevertheless, the low reversibility of the amide bond presents a significant challenge to the direct synthesis of amide-bonded COFs. In this paper, we present a simple method for synthesizing amide COFs.

Distributions and trends in the global burden of young-onset tracheal, bronchus, and lung cancer by region, age, and sex from 1990 to 2021: An age-period-cohort analysis.

Background: The young onset Tracheal, Bronchus, and Lung Cancer (TBLC) exhibits distinct gene mutations and clinical characteristics. With worsening air pollution, the incidence of young onset TBLC is increasing, resulting in significant economic burdens. The specific epidemiology of the disease burden remains elusive.

Pure Mg Cathode for Highly Efficient Single-Layer Organic Light-Emitting Diodes.

Highly efficient single-layer organic light-emitting diodes (OLEDs) are demonstrated by using a pure Mg cathode that is seeded with a small amount of Ag nucleation sites. Bis(4-phenylthieno[3,2-]pyridinato-,C2')(acetylacetonate)iridium(III) (PO-01)-doped devices with three-, two-, and one-region doping configurations exhibit maximum external quantum efficiency (EQE) values of 22.8%, 21.

Characterization of Active Compounds in Sanhuang Shu'ai Decoction for the Management of Ulcerative Colitis: A UHPLC-MS Study.

Objective: The effectiveness of Sanhuang Shu'ai decoction (SSD), a traditional Chinese medicine used to treat diarrhea and colitis, especially ulcerative colitis (UC), is not well understood regarding how its chemical components work.

Methods: This research used ultra-high-performance liquid chromatography (UHPLC)-tandem mass spectrometry (MS), network pharmacology, and molecular docking to understand the active substances and potential mechanisms of SSD in treating UC.

Results: UHPLC and MS analyses identified 710 active components in SSD extracts (ZYTQY) and 387 in SSD-containing serum (HYXQ), with 35 active compounds found in both ZYTQY and HYXQ and 67 active compounds from SSDD (SSD compound obtained directly from the database), along with 6 metabolites that may be key components in its function.

Alanine to glycine substitution in the PyR2 confers sodium channel resistance to Type I pyrethroids.

Background: Aedes aegypti is a primary urban vector of dengue, yellow fever, Zika and chikungunya worldwide. Pyrethroid insecticides are the most effective insecticides for controlling Ae. aegypti.

Long-term Outcomes of PRP Injections for Post-viral Olfactory Loss: A Prospective Cohort Study.

Background: Platelet-rich plasma (PRP) injections have previously been shown to benefit coronavirus disease 2019 (COVID-19)-induced smell loss. It is unknown if that benefit is stable over time. The aim of this study was to assess outcomes at 1-year post-intervention.

Vγ6γδT Cells Participate in Lupus Nephritis in MRL/Lpr Mice.

Background: γδT cells have been implicated in the pathogenesis of autoimmune diseases. The study aims to investigate the abundance of γδT cells in MRL/lpr mice.

Methods: MRL/lpr mice were used as lupus models, while C3H/HeJ mice served as normal controls.

Mitochondria-Nucleus Migration Probe for Ultrasensitive Monitoring of mtDNA Damage in Living Cells.

Mitochondrial DNA (mtDNA) damage is a prevalent phenomenon that has been proven to be implicated in a wide spectrum of diseases. However, the progressive attenuation of probe signals in response to mtDNA damage within living cells inherently limits the sensitivity and precision of current probes for detecting mtDNA damage. Herein, we employ an innovative organelle signal ratio imaging approach, utilizing the mitochondria-nucleus migration probe MCQ, to achieve unparalleled sensitivity in detecting mtDNA damage in living cells.

Association of periodontitis and periodontal parameters with migraine and mortality in people with migraine disease: A nationally representative observational study.

Objective: To investigate the association of periodontitis and clinical periodontal parameters with migraine as well as mortality among people with migraine disease.

Background: Periodontitis has been shown to increase the systemic inflammatory burden thereby promoting various systemic health outcomes; however, the evidence regarding the relationship between periodontitis and migraine is scarce.

Methods: A cross-sectional study was performed, and it included 13,108 participants from the National Health and Nutrition Examination Survey (1999-2004).

CryoSeek II: Cryo-EM analysis of glycofibrils from freshwater reveals well-structured glycans coating linear tetrapeptide repeats.

Despite the recent breakthrough in structure determination and prediction of proteins, the structural investigation of carbohydrates remains a challenge. Here, we report the cryo-EM analysis of a glycofibril found in the freshwater in the Tsinghua Lotus Pond. The fibril, which we name TLP-4, is made of a linear chain of tetrapeptide repeats coated with >4 nm thick glycans.

Low-Cost Intrinsic Flame-Retardant Bio-Based High Performance Polyurethane and its Application in Triboelectric Nanogenerators.

Flammability is a significant challenge in polymer-based electronics. In this regard, triboelectric nanogenerators (TENGs) have enabled a safe means for harvesting mechanical energy for conversion into electrical energy. However, most existing polymers used for TENGs are sourced from petroleum-based raw materials and are highly flammable, which can further accelerate the spread of fire and harm the ecological environment.

Electron Transport Chains Promote Selective Photocatalytic Conversion of CO to Methanol.

The photocatalytic conversion of carbon dioxide (CO) into "liquid sunshine" methanol (CHOH) using semiconductor catalysts has garnered significant attention. Increasing the number of effective electrons and regulating reaction pathways is the key to improving the activity and selectivity of CHOH. Due to the electron transport properties of semiconductor heterojunctions and reduced graphene oxide (rGO), a CoS/CoS-rGO nanocomposite was constructed and applied to the photocatalytic reduction of CO to CHOH.

Role of Individual and Network Factors in HIV Care Continuum Outcomes among PLWH: An Egocentric Network Study in Yunnan, China.

Due to limited data on the determinants of HIV care continuum outcomes among people living with HIV (PLWH) in resource-limited settings, this study aimed to identify individual and social support network factors influencing these outcomes, thereby informing the development of intervention strategies to achieve the UNAIDS 95-95-95 targets. PLWH in Yunnan, China, were recruited using convenience sampling at three stages of the HIV care continuum: linkage to care, antiretroviral therapy (ART) initiation, and viral suppression. An egocentric network design combined with multilevel logit modeling was employed to investigate factors associated with ART initiation and viral suppression.

UCF-101 ameliorates traumatic brain injury by promoting microglia M2 polarization via AMPK/NF-κB pathways in LPS-induced BV2 cells.

Traumatic brain injury (TBI) is a common neurosurgical emergency. As a macrophage in brain, microglia involves in secondary TBI injury. UCF-101, an Omi/HtrA2 inhibitor, protects against neurological disorders.

Health Benefits of Monk Fruit under Traditional Dietary Patterns: Perspective on Immunity and Gut Microbiota Modulatory Functions.

Monk fruit is the mature fruit of Siraitia grosvenorii (Swingle) C. Jeffrey (SG), which contains mogrosides and various nutrients with diverse benefits as a traditional edible herb. The immunomodulatory effects of the ingredients of monk fruit in daily diets are poorly understood.

Calpain 2 promotes Lenvatinib resistance and cancer stem cell traits via both proteolysis-dependent and independent approach in hepatocellular carcinoma.

Lenvatinib, an approved first-line regimen, has been widely applied in hepatocellular carcinoma (HCC). However, clinical response towards Lenvatinib was limited, emphasizing the importance of understanding the underlying mechanism of its resistance. Herein, we employed integrated bioinformatic analysis to identify calpain-2 (CAPN2) as a novel key regulator for Lenvatinib resistance in HCC, and its expression greatly increased in both Lenvatinib-resistant HCC cell lines and clinical samples.

Establishing patient-derived tumor organoids of bone metastasis from lung adenocarcinoma reveals the transcriptomic changes underlying denosumab treatment.

Patient-derived tumor organoids (PDTOs) models have been widely used to investigate the response of primary cancer tissues to anti-cancer agents. Nonetheless, only few case study tried to establish PDTOs and test treatment response based on bone metastasis (BoM) tissues. Fresh BoM tissues were obtained from lung cancer (LC) patients who underwent spinal metastatic tumor surgery for PDTOs culture.

Experimental study on the drag reduction performance of sodium alginate in saline solutions.

Since the discovery of the turbulence drag reduction phenomenon over 70 years ago, it has been recognized that the addition of small quantities of drag-reducing agents to fluids can significantly decrease wall shear stress, thereby enhancing fluid pumpability. In many applications, the fluids often contain salts, such as those used in fracturing processes within the petroleum sector. The aim of this study is to experimentally investigate the effects of salinity, flow rate, and polymer concentration on the drag reduction performance of sodium alginate in circular pipes.

Microcystin-LR Exposure Damages Neurons by Inducing α-Syn Aggregation via MAPK4/GATA2/SNCA and PP2A/GRKs Pathways.

Microcystin-LR (MC-LR) is a natural neurotoxin with strong toxicity, and studies have demonstrated that chronic MC-LR exposure generated Parkinson-like dyskinesia in mice. Parkinson's disease (PD) is a neurologic degenerative disease mostly occurring in elderly people, and the progressive loss of dopaminergic neurons and the formation of Lewy bodies are the hallmark pathological features. The main component of Lewy bodies is α-synuclein (α-syn) encoded by the SNCA gene, and the copy number mutation of SNCA gene can promote the overexpression of α-syn.

Crocodile optimization algorithm for solving real-world optimization problems.

Nature-inspired bionic algorithms have become one of the most fascinating techniques in computational intelligence research, and have shown great potential in real-world challenging problems for their simplicity and flexibility. This paper proposes a novel nature-inspired algorithm, called the crocodile optimization algorithm (COA), which mimics the hunting strategies of crocodiles. In COA, the hunting behavior of crocodiles includes premeditation and waiting hunting.

The effects of high-intensity interval training on cognitive performance: a systematic review and meta-analysis.

Cognitive decline is an important feature of an aging population. Despite the large body of research investigating the effects of high-intensity interval training (HIIT) on cognitive performance, reports of its effectiveness are inconsistent and it is difficult to determine what factors moderate these effects. The purpose of this study was to conduct a meta-analysis of existing randomised controlled trials investigating the effects of HIIT on various domains of cognitive performance, and to further examine the intervention cycle and age-related moderating effects.

NF2 can mediate the expression of CAMK2A in a tissue specific manner.

Meningioma is the most prevalent primary intracranial tumor, with approximately half of patients harboring NF2 alteration. The rationale behind the presence of NF2 alteration in meningiomas and its absence in non-nerve system tumors remains elusive. Therefore, meningiomas and several non-nerve system tumor types were analyzed using KEGG analysis and CRISPR/Cas 9 technology to determine the role of NF2 in regulating tissue specificity.

Optimization of a two-stage emergency logistics system considering public psychological risk perception under earthquake disaster.

To enhance the level of emergency supplies deployment during earthquake disaster, this study focuses on emergency logistics in China. An integrated two-stage optimization framework is adopted to incorporate demand and time satisfaction indicators into the supply allocation and route optimization models, respectively. Firstly, historical data and seismic monitoring information are used to estimate the number of people affected and to forecast the need for emergency supplies; Secondly, the concept of psychological risk perception and the degree of urgency of requirements are introduced.

Evolution characteristics and causes of iodine and fluoride in groundwater of Hengshui city in North China.

Iodine and fluoride are essential trace elements for human health, with both deficiency and excess intake impacting well-being. This study investigates the groundwater funnel area in eastern Hengshui City, utilizing groundwater level and hydrochemical data from 2014 to 2022. Hydrogeochemical methods were employed to comprehensively analyze the evolution characteristics and causes of iodine and fluoride concentrations in the funnel area.