Publications by authors named "Lundholm C"
Background: Evidence suggests a link between food allergy and poor mental health, however, this may be explained by shared genetic and environmental factors. We aimed to investigate the association between food allergy of different severity and mental health in children, and the role of familial factors.
Methods: This population-based, longitudinal cohort study is based on the Child and Adolescent Twin Study in Sweden with questionnaire data reported by parents and/or children.
Article Synopsis
- The study analyzes 36 years of tobacco use trends in northern Sweden using data from the MONICA project, involving over 12,000 participants.
- Cigarette smoking has significantly decreased, with rates dropping to 4.9% for men and 9.7% for women by 2022, while snus (a form of smokeless tobacco) use rose, particularly among men, stabilizing around 26.2%.
- Overall, while smoking rates have fallen, snus usage has become more prevalent across both genders, especially over the past few decades.
Glycaemic control and adult height: a nationwide Swedish cohort study on childhood type 1 diabetes.
J Clin Endocrinol Metab
November 2024
Article Synopsis
- * The study used data from Swedish patients with childhood-onset type 1 diabetes and compared different levels of glycaemic control using statistical methods to see its impact on final adult height and short stature risks.
- * Results showed that poor glycaemic control leads to shorter adult height, especially in males and prepubertal females, indicating that managing diabetes effectively is crucial for growth during key developmental stages.
Article Synopsis
- * In the KARISMA trial, 824 women were analyzed, finding that a decrease in MBD was linked to endoxifen levels of 2-3 ng/mL, particularly in those taking 5-10 mg doses of tamoxifen.
- * The research suggests a potential range of effective endoxifen levels for improving MBD in premenopausal women, but emphasizes the need for studies using established clinical outcomes for confirmation.
The aim is to investigate the evidence for shared genetic architecture between each of asthma, allergic rhinitis and eczema with gastro-esophageal reflux disease (GERD). Structural equation models (SEM) and polygenic risk score (PRS) analyses are applied to three Swedish twin cohorts (n = 46,582) and reveal a modest genetic correlation between GERD and asthma of 0.18 and bidirectional PRS and phenotypic associations ranging between OR 1.
View Article and Find Full Text PDFObjective: To study school achievement in grade 9 of compulsory school in children with congenital hypothyroidism (CH), both those detected by the national screening program and those with a normal screening result and thus diagnosed later.
Study Design: Nationwide study of children in the Swedish Medical Birth Register (n = 1 547 927) from 1982 through 1997, linked to the neonatal screening CH cohort and the National School Register. Dried blood spot (DBS) samples are collected from all newborn infants, according to the neonatal screening program.
Objectives: Although most countries recommend amoxicillin for paediatric pneumonia, there is a long tradition of treatment with penicillin V (PcV) in Sweden, thus not empirically covering Haemophilus influenzae. There are, however, large regional differences in treatment practice. The aim was to compare clinical outcomes (treatment failure and severe complications), in children aged 1-59 months treated with PcV vs.
View Article and Find Full Text PDFBackground: Little is known about shared origins between inflammatory bowel disease (IBD) and allergic diseases (asthma, allergic rhinitis, and eczema). We aimed to expand current knowledge on the etiological sources of comorbidities between these disorders using a range of genetically informed methods.
Methods: Within-individual and familial co-aggregation analysis was applied to 2 873 445 individuals born in Sweden from 1987 to 2014 and their first- and second-degree relatives.
Background: Maternal psychological stress during pregnancy and postnatally has been shown to be associated with offspring atopic diseases (asthma, atopic dermatitis and allergic rhinitis). The aim of this study was to assess whether this association may be attributable to the child's own mental health disorders.
Method: The study population included 15,092 twin children born 2002-2010 in Sweden.
Article Synopsis
- Budding yeast cell membrane formation of buds is influenced by the protein Cdc42 through reactions and diffusion, modeled by the Schnakenberg system of partial differential equations.
- The Schnakenberg system is known for creating patterns driven by diffusion, but the impact of accumulated bud scars on these patterns is not fully understood.
- By simulating a bud scar as a hole on a sphere and analyzing how it affects the Laplace-Beltrami operator, researchers found that significant pattern formation persists even with large bud scars, supporting the idea that bud formation relies on diffusion-driven instability.
Background: Hypospadias is a common genital malformation among boys. Studies indicate that hypospadias is associated with a higher risk of testicular cancer. Other forms of urological cancer may be linked to hypospadias via a mutual aetiology, hormonal dysfunction, or hypospadias complications, but this has not yet been studied.
View Article and Find Full Text PDFBackground: Novel immunisation methods against respiratory syncytial virus (RSV) are emerging, but knowledge of risk factors for severe RSV disease is insufficient for optimal targeting of interventions against them. Our aims were to identify predictors for RSV hospital admission from registry-based data and to develop and validate a clinical prediction model to guide RSV immunoprophylaxis for infants younger than 1 year.
Methods: In this model development and validation study, we studied all infants born in Finland between June 1, 1997, and May 31, 2020, and in Sweden between June 1, 2006, and May 31, 2020, along with the data for their parents and siblings.
Objective: This study aims to evaluate the neonatal screening for congenital hypothyroidism (CH) and the diagnosis CH in the national health registers and to study the effects of lowering screening thyroid-stimulating hormone (TSH) threshold on the incidence of CH and birth characteristics of screening positive and negative CH children.
Design: This is a nationwide register-study of all children (n = 3 427 240) in the Swedish Medical Birth Register (MBR) and national cohort for screening positive infants (n = 1577) in 1980-2013.
Methods: The study population was further linked to several other Swedish health registers.
Background: Adherence to adjuvant tamoxifen therapy is suboptimal, and acceptance of tamoxifen for primary prevention is poor. Published results indicate effect of low-dose tamoxifen therapy. Using questionnaire data from a randomised controlled trial, we describe side effects of standard and low-dose tamoxifen in healthy women.
View Article and Find Full Text PDFIntroduction: To investigate the association between maternal depression/anxiety during pregnancy and offspring type 1 diabetes, to assess the specific importance of exposure during pregnancy by comparing across different exposure periods before and/or after pregnancy, and to explore potential unmeasured familial confounding.
Research Design And Methods: This was a population-based cohort including 1 807 809 offspring born in Sweden 2002-2019. From national registers, data were available on diagnosis or medication prescription for depression/anxiety in and around pregnancy, as well as incident cases of type 1 diabetes defined through diagnosis or insulin treatment.
Objective: This study was undertaken to examine the association between montelukast use, β2-adrenoreceptor (β2AR) agonist use, and later Parkinson disease (PD).
Methods: We ascertained use of β2AR agonists (430,885 individuals) and montelukast (23,315 individuals) from July 1, 2005 to June 30, 2007, and followed 5,186,886 PD-free individuals from July 1, 2007 to December 31, 2013 for incident PD diagnosis. We estimated hazard ratios and 95% confidence intervals using Cox regressions.
Background: The aim was to study whether non-combustible nicotine (Swedish snuff) use in pregnancy is associated with elevated risk of post neonatal mortality, Sudden Infant Death Syndrome (SIDS), and Sudden Unexpected Infant Death (SUID) and to study how cessation before the antenatal booking influenced these risks.
Methods: This was a population-based register study of all infants with information on tobacco exposure in early pregnancy born in Sweden 1999-2019, n = 2,061,514. Self-reported tobacco use in early pregnancy was categorized as nonuse, snuff use, and moderate and heavy smoking.
Mode of delivery and offspring atopic dermatitis in a Swedish nationwide study.
Pediatr Allergy Immunol
January 2023
Background: Atopic dermatitis is a common chronic childhood disease associated with significant morbidity and healthcare costs. There is a known association between caesarean section and asthma, but the relationship between caesarean section and offspring atopic dermatitis remains uncertain.
Methods: We conducted a register-based nationwide cohort study including children born in Sweden between January 2006 and December 2018.
Background: Although severe acute COVID-19 is rare in children, SARS-CoV-2 infection can trigger the novel post-infectious condition multisystem inflammatory syndrome in children (MIS-C). Increased knowledge on risk factors for MIS-C could improve our understanding of the pathogenesis of the condition and better guide targeted public health interventions. The aim of the study was to assess risk factors for MIS-C with the aim to identify vulnerable children.
View Article and Find Full Text PDFBackground: Hypospadias is a common congenital malformation often related to the effect of androgens in utero. While hypogonadism is associated with many potential health risks including metabolic and cardiovascular disease, the risk of clinical hypogonadism and comorbidities in men with hypospadias later in life has not been studied.
Objectives: Investigate the risk of hypogonadism and somatic comorbidities in adolescents and men born with hypospadias.
Background: There is some evidence that autism spectrum disorder (ASD) frequently co-occurs with immune-mediated conditions including asthma. We aimed to explore the familial co-aggregation of ASD and asthma using different genetically informed designs.
Methods: We first examined familial co-aggregation of asthma and ASD in individuals born in Sweden from 1992 to 2007 ( = 1 569 944), including their full- and half-siblings ( = 1 704 388 and 356 544 pairs) and full cousins ( = 3 921 890 pairs), identified using Swedish register data.
Introduction: Gastro-oesophageal reflux disease (GERD) is the most common non-allergic comorbidity in adults with asthma; however, comorbidity with other atopic diseases such as eczema and hay fever is unclear. The objective was to assess the comorbidity of GERD with asthma and atopic diseases and to investigate possible mechanisms, including genetic and/or affective factors.
Methods: A co-twin control study harnessing 46 583 adult twins.
Objective: Stress during pregnancy may decrease gestational age at birth and birth size. We aimed to investigate the associations between maternal subjective stress measures, salivary cortisol, and perinatal outcomes.
Methods: A cohort of pregnant women (n = 1693) was recruited from eight antenatal care clinics in Stockholm, Sweden.
Background: The observed association between the parental socioeconomic status (SES, measured as education/income) and asthma or wheezing in offspring may be explained by confounding of unmeasured factors (shared genes and family environment). We aimed to study the association between parental SES and asthma/wheeze using cousin comparison.
Method: Data were collected on individuals born in Sweden 2001-2013.