Publications by authors named "Lundgren P"
Introduction Retinopathy of prematurity (ROP) is a leading cause of preventable childhood blindness. We investigated the association of early postnatal low-dose intravenous hydrocortisone used for the prevention of bronchopulmonary dysplasia (BPD) with ROP-outcome among extremely preterm infants in a Swedish cohort. Methods This retrospective cohort study included extremely preterm infants born before 28 weeks of gestational age (GA).
View Article and Find Full Text PDFAim: To analyse the challenges faced by parents of extremely preterm infants born before 24 weeks of gestation and the potential buffering effect of perceived resources on the family's health continuum.
Methods: The qualitative data were obtained from 70 parents of 70 infants born before 24 weeks of gestation, through open-ended questions in a survey. An inductive content analysis was conducted to identify themes and patterns in the parents' experiences.
Background: Two risk factors for severe retinopathy of prematurity (ROP) in extremely preterm infants are thrombocytopenia and low levels of arachidonic acid (AA) and docosahexaenoic acid (DHA). To date, these risk factors have not been linked.
Method: Infants born < 28 weeks gestational age (GA) from 2016 to 2019 were randomized to postnatal enteral AA/DHA supplementation or standard care (controls).
Aim: To investigate the association between retinopathy of prematurity and autism spectrum disorder in extremely preterm children.
Methods: Data in children born extremely preterm at <28 weeks' gestational age in the Region Västra Götaland, 2013-2017, were analysed for association between retinopathy of prematurity and neurodevelopmental disorders. We focussed on autism spectrum disorder and excluded children with perinatal brain injuries or genetic disorders.
Article Synopsis
- Guidelines for cardiac arrest management were analyzed to assess the strength and quality of the evidence supporting them, revealing both strengths and significant gaps in knowledge.
- The review of the 2020 American Heart Association (AHA) Guidelines identified 254 recommendations, mostly classified under advanced life support (ALS) and basic life support (BLS), but only 1% of recommendations were based on the strongest level of evidence (LOE A).
- Only 32% of the highest class recommendations were backed by strong evidence (LOE A or B), highlighting the need for more rigorous research, especially randomized trials, to improve the quality of guidelines.
Background: This systematic review evaluates the effect of audit and feedback (A&F) interventions targeting antibiotic prescribing in primary care and examines factors that may explain the variation in effectiveness.
Methods: Randomized controlled trials (RCTs) involving A&F interventions targeting antibiotic prescribing in primary care were included in the systematic review. Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, CINAHL, and ClinicalTrials.
Article Synopsis
- * A study analyzed 15,856 ECGs from emergency patients in Sweden and trained a convolutional neural network (ResNet) to predict troponin elevation, achieving an accuracy of 71.43% and a high negative predictive value of 0.8660.
- * The model's promising performance suggests that similar neural networks could be used in emergency settings for rapid triage of patients suspected of having heart issues.
Article Synopsis
- Researchers developed a predictive model called the Pre-ECPR score to enhance patient selection for extracorporeal cardiopulmonary resuscitation (ECPR), which currently only has a favorable outcome rate of about 20%.
- The study analyzed data from 120 normothermic ECPR patients at a single hospital and found that the Pre-ECPR score, using various health indicators, outperformed existing selection criteria from the Extracorporeal Life Support Organization (ELSO).
- The Pre-ECPR score achieved a strong predictive ability (AUC of 0.87) for identifying patients likely to have good outcomes, significantly boosting the chances of successful ECPR treatment over traditional methods.
Pathological neovascularization in retinopathy of prematurity (ROP) can cause visual impairment in preterm infants. Current ROP treatments which are not preventative and only address late neovascular ROP, are costly and can lead to severe complications. We showed that topical 0.
View Article and Find Full Text PDFUnlabelled: Out-of-hospital cardiac arrest (OHCA) is a critical condition with low survival rates. In patients with a return of spontaneous circulation, brain injury is a leading cause of death. In this study, we propose an interpretable machine learning approach for predicting neurologic outcome after OHCA, using information available at the time of hospital admission.
View Article and Find Full Text PDFCarbon fibers (CFs) are fabricated by blending hardwood kraft lignin (HKL) and cellulose. Various compositions of HKL and cellulose in blended solutions are air-gap spun in 1-ethyl-3-methylimidazolium acetate (EMIM OAc), resulting in the production of virtually bead-free quality fibers. The synthesized HKL-cellulose fibers are thermostabilized and carbonized to achieve CFs, and consequently their electrical and mechanical properties are evaluated.
View Article and Find Full Text PDFArticle Synopsis
- - The SWENOTECA-MIR study evaluates the effectiveness of miR-371a-3p as a new marker for detecting viable tumors in metastatic germ cell tumor patients undergoing retroperitoneal lymph node dissection (RPLND).
- - In the study of 114 patients, miR-371a-3p showed mixed results, with better performance in seminoma patients than in nonseminomas, particularly before chemotherapy.
- - Overall, while miR-371a-3p demonstrated high specificity in certain groups, its overall sensitivity, especially post-chemotherapy, was low, highlighting potential limitations in using it as a reliable marker for viable tumor detection.
Aim: To assess experience of care, well-being of parents and children's development in a cohort of extremely premature infants born <24 weeks of gestation in Sweden from 2007 to 2018.
Methods: A survey based on multiple questionnaires answered by 124/349 (35.5%) parents.
Pathological neovascularization in retinopathy of prematurity (ROP) can cause visual impairment in preterm infants. Current ROP treatments which are not preventative and only address late neovascular ROP, are costly and can lead to severe complications. We showed that topical 0.
View Article and Find Full Text PDFBackground And Objective: There is an unmet need to avoid long-term morbidity associated with standard cytotoxic treatment for low-volume metastatic seminoma. Our aim was to assess the oncological efficacy and surgical safety of retroperitoneal lymph node dissection (RPLND) as treatment in a population-based cohort of metastatic seminoma patients with limited retroperitoneal lymphadenopathy.
Methods: Sixty-two seminoma patients in Norway and Sweden were included in the cohort from 2019 to 2022.
Article Synopsis
- - The study aims to enhance a machine learning model that predicts survival chances for patients experiencing out-of-hospital cardiac arrest (OHCA), addressing a significant health issue with only 10% survival post-ICU treatment.
- - Researchers analyzed over 55,600 OHCA cases from the Swedish Cardiopulmonary Resuscitation Registry, evaluating various predictive models like LightGBM and XGB, focusing on their ability to reduce false negatives and improve overall prediction accuracy.
- - The refined model achieved a high receiver operating characteristic score (AUC ROC of 0.96), demonstrating strong calibration and reliability, especially in low likelihood survival scenarios (0-10%), and is accessible for use at www.gocares.se. *
Background: No previous study has evaluated patients attitudes towards inclusion in an ongoing cardiac arrest clinical trial. The aim of this study was to assess patientś willingness and motives to participate in the ongoing randomized controlled drug trial "Vasopressin and Steroids in addition to Adrenaline in cardiac arrest" (VAST-A trial) in case of an in-hospital cardiac arrest (IHCA).
Objectives: Hospitalized patients, men ≥ 18 and women ≥ 50 years, were asked for informed consent for inclusion in the VAST-A trial in case of an IHCA, the reason for approving or declining inclusion in the trial and baseline characteristics.
: Recent decades have witnessed a sharp increase in research investigating the association between hearing loss and cognitive impairment. Few previous studies have stratified for sex when investigating this issue, where results were inconsistent and require further clarification. Thus, the objective was to investigate the association between self-reported hearing loss and levels of cognitive impairment, stratified for sex.
View Article and Find Full Text PDFBackground: Antibiotic overuse and misuse in primary care are common, highlighting the importance of antimicrobial stewardship (AMS) efforts in this setting. Audit and feedback (A&F) interventions can improve professional practice and performance in some settings.
Objectives And Methods: To leverage the expertise from international members of the Joint Programming Initiative on Antimicrobial Resistance - Primary care Antibiotic Audit and feedback Network (JPIAMR-PAAN).
Article Synopsis
- Accidental hypothermia is a significant risk in trauma patients, and maintaining the temperature of infusion fluids is crucial during treatment to reduce morbidity and mortality.
- A study was conducted to assess how different ambient temperatures and flow rates affect the temperature of preheated infusion fluids in a prehospital emergency setting.
- Results indicated that to keep preheated fluids above 37°C when reaching the patient, higher flow rates and warmer ambient temperatures are necessary; lower temperatures and flow rates lead to greater heat loss in the fluids.
The purpose of this study is to evaluate the treatment safety of thermal ablation compared to surgical treatment of T1a tumors (small renal masses) at a high-volume center. We conducted an observational single-center study based on data collected form the National Swedish Kidney Cancer Register (NSKCR) between 2015 and 2021. In total, 444 treatments of T1a tumors were included.
View Article and Find Full Text PDFBackground: In neurologic prognostication of comatose survivors from cardiac arrest, two independent predictors of poor outcome are the loss of the Pupillary light reflex (PLR) and the loss of the N20 response from Somatosensory Evoked potentials (SSEP). The PLR can be quantitatively assessed by pupillometry. Both tests depend on the midbrain, in which a dysfunction reflects a severe hypoxic injury.
View Article and Find Full Text PDFBackground: It is unclear whether an implantable cardioverter-defibrillator (ICD) is generally beneficial in survivors of out-of-hospital cardiac arrest (OHCA).
Objective: We studied the association between ICD implantation prior to discharge and survival in patients with cardiac aetiology or initial shockable rhythm in OHCA.
Design: We conducted a retrospective cohort study in the Swedish Registry for Cardiopulmonary Resuscitation.
Article Synopsis
- A study was conducted in Sweden to assess the effectiveness of drones in delivering automated external defibrillators (AEDs) quickly to locations of suspected cardiac arrests before ambulances arrive.
- The research involved deploying five AED-equipped drones across areas with around 200,000 residents and analyzing the success rate and timing of these deliveries.
- Out of 211 cardiac arrest alerts, drones were dispatched for 72 cases, successfully delivering AEDs in 81% of those instances, which showed a potential for significantly quicker defibrillation access.