Publications by authors named "Luna Zhang"

Objective: The study investigated microRNA-152-3p-mediated autophagy and sensitivity of paclitaxel-resistant ovarian cancer cells.

Methods: The miR-152-3p mimics and miR-152-3p inhibitor were transfected in A2780 cells and A2780T cells, and the scrambled sequences were transfected as a negative control group, the transfection efficiency was detected by qPCR technology. MTT was used to detect the proliferation and IC50 value of the cells after transfection.

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Cerebral ischemic stroke, neuronal death, and inflammation bring difficulties in neuroprotection and rehabilitation. In this study, we developed and designed the ability of natural lactoferrin-polyethylene glycol-polyphenylalanine-baicalein nanomicelles (LF-PEG-PPhe-Bai) to target and reduce these pathological processes, such as neurological damage and cognitive impairment in the stages of poststroke. Nanomicelles made from biocompatible materials have improved bioavailability and targeted distribution to afflicted brain areas.

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Myocardial fibrosis (MF) significantly compromises cardiovascular health by affecting cardiac function through excessive collagen deposition. This impairs myocardial contraction and relaxation and leads to severe complications and increased mortality. The present study employed network pharmacology and assays to investigate the bioactive compounds of and their targets.

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The phenotypic plasticity hypothesis suggests that exotic plants may have greater phenotypic plasticity than native plants. However, whether phenotypic changes vary according to different environmental factors has not been well studied. We conducted a multi-species greenhouse experiment to study the responses of six different phenotypic traits, namely height, leaf number, specific leaf area, total biomass, root mass fraction, and leaf mass fraction, of native and invasive species to nutrients, water, and light.

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Multiple myeloma (MM) is a cancer of plasma cells in the bone marrow (BM) and represents the second most common hematological malignancy in the world. The MM tumor microenvironment (TME) within the BM niche consists of a wide range of elements which play important roles in supporting MM disease progression, survival, proliferation, angiogenesis, as well as drug resistance. Together, the TME fosters an immunosuppressive environment in which immune recognition and response are repressed.

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Water table decline is one of the most serious environmental problems in the peatland in the Qinghai-Tibetan Plateau. However, the effect of water table decline on the structure of aboveground arthropod communities is still not clear. We investigated changes in the abundance of different arthropod groups, and estimated the abundance, height, and biomass of the plant community in a soil water table reduction experiment to reveal the effect of water table decline on the arthropod community structure.

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Environmental DNA (eDNA) is a novel, non-invasive sampling procedure that allows the obtaining of genetic material directly from environmental samples without any evidence of biological sources. The eDNA methodology can greatly benefit from coupling it to reliable, portable and cost-effective tools able to perform decentralized measurements directly at the site of need and in resource-limited settings. Herein, we report a simple method for the selective analysis of eDNA using a magneto-assay with electrochemical detection.

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A novel approach for ultrafast and temperature-insensitive strain interrogation using a polarization-maintaining photonic crystal fiber (PM-PCF) based Sagnac loop interferometer (SLI) and linear wavelength-to-time (WTT) mapping is proposed and experimentally demonstrated. The PM-PCF incorporated in the SLI is used as the sensing element to achieve stable strain sensing with ultra-low temperature-dependence due to its intrinsic thermal insensitivity, which can be used to eliminate the cross-sensitivity effect and increase the measurement accuracy. A dispersive element is employed to realize the WTT mapping and real-time strain interrogation is obtained by converting the strain-encoded wavelength shift to time shift in the temporal domain, which can be directly monitored by a real-time oscilloscope.

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Drug resistance and dose-limiting toxicities are significant barriers for treatment of multiple myeloma (MM). Bone marrow microenvironment (BMME) plays a major role in drug resistance in MM. Drug delivery with targeted nanoparticles have been shown to improve specificity and efficacy and reduce toxicity.

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Article Synopsis
  • Soil respiration is a key source of carbon in ecosystems and is influenced by soil nutrient levels, particularly nitrogen (N) and phosphorus (P).
  • A study conducted from 2013 to 2015 in northern China revealed that nitrogen addition increased soil respiration by 9.5%, but phosphorus alone had no significant impact.
  • Importantly, nitrogen enhanced soil respiration more when combined with phosphorus, suggesting that nutrient interactions should be considered in models predicting carbon cycling in terrestrial ecosystems.
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As a novel type of post-translational modification, lysine 2-Hydroxyisobutyrylation (K ) plays an important role in gene transcription and signal transduction. In order to understand its regulatory mechanism, the essential step is the recognition of K sites. Thousands of K sites have been experimentally verified across five different species.

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A large number of post-translational modifications (PTMs) in proteins are buried in the unassigned mass spectrometric (MS) spectra in shot-gun proteomics datasets. Because the modified peptide fragments are low in abundance relative to the corresponding non-modified versions, it is critical to develop tools that allow facile evaluation of assignment of PTMs based on the MS/MS spectra. Such tools will preferably have the ability to allow comparison of fragment ion spectra and retention time between the modified and unmodified peptide pairs or group.

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We propose and demonstrate a four-wavelength-switchable erbium-doped fiber laser (4WS-EDFL) with a four-channel superimposed high-birefringence fiber Bragg grating (SI-HBFBG) and a dual-coupler ring based compound-cavity (DCR-CC) filter. Both for the first time, a SI-HBFBG as a four-channel reflective filter is used in a multi-wavelength switchable fiber laser to define wavelength channels and a DCR-CC filter is used to select a single mode from dense longitudinal-modes in a fiber laser. We present in detail how to design, fabricate, and characterize the DCR-CC filter with both theoretical analysis and experimental results, which we believe is the first systematic approach for making a compound-cavity based filter used for selecting single-longitudinal mode (SLM) in a fiber laser.

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Introduction: With the legalization of both medical and recreational marijuana in some countries and a few US states, its use has become more widely prevalent. Both exogenous cannabinoids such as tetrahydrocannabinol (THC) and endogenous cannabinoids (endocannabinoids) have been shown to affect female gonadotropin pathways and female sexuality. Yet, our understanding of the mechanisms and effects on female sexual function is limited.

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A synthetic method for preparing a Pluronic F127 (F127)-stabilized graphene (GO) supramolecular hydrogel as a safe nanovehicle for combination treatment has been studied. Doxorubicin (DOX) as a model drug is non-covalently bound on the great surface area of GO due to strong π-π interaction, hydrophobic interaction, and the strongest hydrogen bonding. drug release experiments revealed that this F127-stabilized GO supramolecular hydrogel has a sustained drug release characteristic.

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The immunoproteasome is an inducible host mechanism that aids in the clearance of damaged proteins. The immunoproteasome also influences immune function by enhancing peptide presentation by MHC class I and promotes inflammation via IκB degradation and activation of NF-κB. We used mouse adenovirus type 1 (MAV-1) to characterize the role of the immunoproteasome in adenovirus pathogenesis.

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Objectives: This work aimed to evaluate pharmacokinetics, biodistribution, toxicity, and antitumor activities of a highly stable long-/medium-chain triglycerides (LCT/MCT)-based etoposide parenteral emulsion (EPE) in comparison to etoposide parenteral solution (EPS).

Methods: Using high-pressure homogenization method, EPE was prepared and sterilized at 121°C for 10 min by autoclaving. The biological samples were analyzed using the UPLC-ESI-MS/MS method.

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